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PHPT1

GENERAL INFORMATION

Gene name

 PHPT1

Gene description

 Phosphohistidine phosphatase 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA020952 , CAB013584
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 PHPT1 (HGNC Symbol)

Synonyms

 bA216L13.10, CGI-202, DKFZp564M173, HSPC141, PHP14

Description

 Phosphohistidine phosphatase 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes an enzyme that catalyzes the reversible dephosphorylation of histidine residues in proteins. It may be involved in the dephosphorylation of G-beta and ATP citrate lyase and in negatively regulating CD4 T lymphocytes by dephosphorylation and inhibition of KCa3.1 channels. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

Chromosome

 9

Cytoband

 q34.3

Chromosome location (bp)

 136848724 - 136851027

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000054148 (version 83.38)

Entrez gene

 29085

UniProt

 Q9NRX4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NRX4

Antibodypedia

 PHPT1 antibodies

PROTEIN BROWSER
PHPT1-001
PHPT1-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PHPT1-001
ENSP00000247665
ENST00000247665
Q9NRX4 [Direct mapping]
14 kDa phosphohistidine phosphatase
V9HWC4 [Target identity:100%; Query identity:100%]
Epididymis secretory sperm binding protein Li 132P; Phosphohistidine phosphatase 1, isoform CRA_a
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004721 [phosphoprotein phosphatase activity]
GO:0005829 [cytosol]
GO:0006470 [protein dephosphorylation]
GO:0008969 [phosphohistidine phosphatase activity]
GO:0019855 [calcium channel inhibitor activity]
GO:0035774 [positive regulation of insulin secretion involved in cellular response to glucose stimulus]
GO:0035971 [peptidyl-histidine dephosphorylation]
GO:0044325 [ion channel binding]
GO:0050860 [negative regulation of T cell receptor signaling pathway]
GO:0051350 [negative regulation of lyase activity]
GO:0070062 [extracellular exosome]
GO:2000147 [positive regulation of cell motility]
GO:2000249 [regulation of actin cytoskeleton reorganization]
GO:2000984 [negative regulation of ATP citrate synthase activity]
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 125 aa
13.8 kDa 		No 0
PHPT1-003
ENSP00000360724
ENST00000371661
Q9NRX4 [Direct mapping]
14 kDa phosphohistidine phosphatase
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004721 [phosphoprotein phosphatase activity]
GO:0005829 [cytosol]
GO:0006470 [protein dephosphorylation]
GO:0008969 [phosphohistidine phosphatase activity]
GO:0019855 [calcium channel inhibitor activity]
GO:0035971 [peptidyl-histidine dephosphorylation]
GO:0044325 [ion channel binding]
GO:0050860 [negative regulation of T cell receptor signaling pathway]
GO:0051350 [negative regulation of lyase activity]
GO:0070062 [extracellular exosome]
GO:2000147 [positive regulation of cell motility]
GO:2000249 [regulation of actin cytoskeleton reorganization]
GO:2000984 [negative regulation of ATP citrate synthase activity]
Show all
 124 aa
13.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.