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ENTPD2

GENERAL INFORMATION

Gene name

 ENTPD2

Gene description

 Ectonucleoside triphosphate diphosphohydrolase 2

Protein class

 Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Mixed
FANTOM5:Mixed

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several different tissue types.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA017676
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed

GENE INFORMATION

Gene name

 ENTPD2 (HGNC Symbol)

Synonyms

 CD39L1, NTPDase-2

Description

 Ectonucleoside triphosphate diphosphohydrolase 2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is the type 2 enzyme of the ecto-nucleoside triphosphate diphosphohydrolase family (E-NTPDase). E-NTPDases are a family of ecto-nucleosidases that hydrolyze 5'-triphosphates. This ecto-ATPase is an integral membrane protein. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

Chromosome

 9

Cytoband

 q34.3

Chromosome location (bp)

 137048098 - 137054045

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000054179 (version 83.38)

Entrez gene

 954

UniProt

 Q9Y5L3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y5L3

Antibodypedia

 ENTPD2 antibodies

PROTEIN BROWSER
ENTPD2-001
ENTPD2-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ENTPD2-001
ENSP00000347213
ENST00000355097
Q9Y5L3 [Direct mapping]
Ectonucleoside triphosphate diphosphohydrolase 2
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005605 [basal lamina]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0009181 [purine ribonucleoside diphosphate catabolic process]
GO:0009986 [cell surface]
GO:0010996 [response to auditory stimulus]
GO:0016021 [integral component of membrane]
GO:0016787 [hydrolase activity]
GO:0016887 [ATPase activity]
GO:0017110 [nucleoside-diphosphatase activity]
GO:0017111 [nucleoside-triphosphatase activity]
GO:0030168 [platelet activation]
GO:0031253 [cell projection membrane]
GO:0035457 [cellular response to interferon-alpha]
GO:0042802 [identical protein binding]
GO:0043262 [adenosine-diphosphatase activity]
GO:0044297 [cell body]
GO:0051260 [protein homooligomerization]
GO:0070062 [extracellular exosome]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071354 [cellular response to interleukin-6]
GO:0071356 [cellular response to tumor necrosis factor]
Show all
 495 aa
53.7 kDa 		Yes 1
ENTPD2-003
ENSP00000312494
ENST00000312665
Q9Y5L3 [Direct mapping]
Ectonucleoside triphosphate diphosphohydrolase 2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0005789 [endoplasmic reticulum membrane]
GO:0016021 [integral component of membrane]
GO:0016787 [hydrolase activity]
GO:0070062 [extracellular exosome]
Show all
 472 aa
51.2 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.