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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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OPN3
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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

OPN3

Gene description

Opsin 3

Protein class

G-protein coupled receptors
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (ASC TERT1)
HPA (normal tissue):Tissue enhanced (placenta)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data.

Reliability score

Uncertain based on 1 antibody.
CAB013682
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PROGNOSTIC SUMMARY

Prognostic marker in cervical cancer (unfavourable) and glioma (unfavourable).
Cervical cancer p<0.001
Glioma p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

CAB013682

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most liver, pancreatic and prostate cancers along with several colorectal, breast and lung cancers showed moderate cytoplasmic positivity. Remaining cancer tissues were in general weakly stained or negative.

GENE INFORMATION

Gene name

OPN3 (HGNC Symbol)

Synonyms

ECPN, encephalopsin, ERO, NMO-1, PPP1R116

Description

Opsin 3 (HGNC Symbol)

Entrez gene summary

Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. In addition to the visual opsins, mammals possess several photoreceptive non-visual opsins that are expressed in extraocular tissues. This gene, opsin 3, is strongly expressed in brain and testis and weakly expressed in liver, placenta, heart, lung, skeletal muscle, kidney, and pancreas. The gene may also be expressed in the retina. The protein has the canonical features of a photoreceptive opsin protein. [provided by RefSeq, Jul 2008]

Chromosome

1

Cytoband

q43

Chromosome location (bp)

241590102 - 241677376

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000054277 (version 83.38)

Entrez gene

23596

UniProt

Q9H1Y3 (UniProt - Evidence at protein level)

neXtProt

NX_Q9H1Y3

Antibodypedia

OPN3 antibodies

PROTEIN BROWSER

OPN3-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

OPN3-001
ENSP00000355512
ENST00000366554
Q9H1Y3 [Direct mapping]
Opsin-3
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G-protein coupled receptors
   GPCRs excl olfactory receptors
   Opsins
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0004930 [G-protein coupled receptor activity]
GO:0005887 [integral component of plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007602 [phototransduction]
GO:0008020 [G-protein coupled photoreceptor activity]
GO:0009583 [detection of light stimulus]
GO:0009584 [detection of visible light]
GO:0009881 [photoreceptor activity]
GO:0016021 [integral component of membrane]
GO:0018298 [protein-chromophore linkage]
GO:0042752 [regulation of circadian rhythm]
Show all
402 aa
44.9 kDa
No 7

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