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OPN3

GENERAL INFORMATION

Gene name

 OPN3

Gene description

 Opsin 3

Protein class

 G-protein coupled receptors
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (ASC TERT1)
HPA (normal tissue):Tissue enhanced (placenta)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
CAB013682
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PROGNOSTIC SUMMARY
Prognostic marker in cervical cancer (unfavourable) and glioma (unfavourable).
Cervical cancer p<0.001
Glioma p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB013682

GENE INFORMATION

Gene name

 OPN3 (HGNC Symbol)

Synonyms

 ECPN, encephalopsin, ERO, NMO-1, PPP1R116

Description

 Opsin 3 (HGNC Symbol)

Entrez gene summary

 Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. In addition to the visual opsins, mammals possess several photoreceptive non-visual opsins that are expressed in extraocular tissues. This gene, opsin 3, is strongly expressed in brain and testis and weakly expressed in liver, placenta, heart, lung, skeletal muscle, kidney, and pancreas. The gene may also be expressed in the retina. The protein has the canonical features of a photoreceptive opsin protein. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 q43

Chromosome location (bp)

 241590102 - 241677376

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000054277 (version 83.38)

Entrez gene

 23596

UniProt

 Q9H1Y3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H1Y3

Antibodypedia

 OPN3 antibodies

PROTEIN BROWSER
OPN3-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
OPN3-001
ENSP00000355512
ENST00000366554
Q9H1Y3 [Direct mapping]
Opsin-3
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G-protein coupled receptors
   GPCRs excl olfactory receptors
   Opsins
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
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GO:0004930 [G-protein coupled receptor activity]
GO:0005887 [integral component of plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007602 [phototransduction]
GO:0008020 [G-protein coupled photoreceptor activity]
GO:0009583 [detection of light stimulus]
GO:0009584 [detection of visible light]
GO:0009881 [photoreceptor activity]
GO:0016021 [integral component of membrane]
GO:0018298 [protein-chromophore linkage]
GO:0042752 [regulation of circadian rhythm]
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 402 aa
44.9 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.