Expression of HHAT in cancer - Summary - The Human Protein Atlas

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HHAT

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	HHAT
Gene description	Hedgehog acyltransferase
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (HMC-1, RH-30)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression with a granular patter in several different tissue types.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA016462
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA016462

GENE INFORMATION
Gene name	HHAT (HGNC Symbol)
Synonyms	FLJ10724, GUP2, MART-2, MART2, rasp, sit, ski, Skn
Description	Hedgehog acyltransferase (HGNC Symbol)
Entrez gene summary	'Skinny hedgehog' (SKI1) encodes an enzyme that acts within the secretory pathway to catalyze amino-terminal palmitoylation of 'hedgehog' (see MIM 600725).[supplied by OMIM, Jul 2002]
Chromosome	1
Cytoband	q32.2
Chromosome location (bp)	210328252 - 210676296
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000054392 (version 83.38)
Entrez gene	55733
UniProt	Q5VTY9 (UniProt - Evidence at protein level)
neXtProt	NX_Q5VTY9
Antibodypedia	HHAT antibodies

PROTEIN BROWSER

HHAT-001	HHAT-002	HHAT-003	HHAT-004	HHAT-201	HHAT-202	HHAT-203	HHAT-204	HHAT-205

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HHAT-001 ENSP00000261458 ENST00000261458	Q5VTY9 [Direct mapping] Protein-cysteine N-palmitoyltransferase HHAT Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005525 [GTP binding] GO:0005789 [endoplasmic reticulum membrane] GO:0007275 [multicellular organismal development] GO:0016021 [integral component of membrane] GO:1903955 [positive regulation of protein targeting to mitochondrion] Show all	493 aa 57.3 kDa	No	>9
HHAT-002 ENSP00000355976 ENST00000367009	B1AK61 [Direct mapping] Protein-cysteine N-palmitoyltransferase HHAT; cDNA FLJ34867 fis, clone NT2NE2014176, highly similar to Protein-cysteine N-palmitoyltransferase HHAT (EC 2.3.1.-) Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016740 [transferase activity] Show all	183 aa 20.8 kDa	No	4
HHAT-003 ENSP00000413399 ENST00000426968	A0A075B6R5 [Direct mapping] Protein-cysteine N-palmitoyltransferase HHAT Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	207 aa 24.2 kDa	Yes	4
HHAT-004 ENSP00000355977 ENST00000367010	Q5VTY9 [Direct mapping] Protein-cysteine N-palmitoyltransferase HHAT Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005525 [GTP binding] GO:0005789 [endoplasmic reticulum membrane] GO:0007275 [multicellular organismal development] GO:0016021 [integral component of membrane] GO:1903955 [positive regulation of protein targeting to mitochondrion] Show all	493 aa 57.3 kDa	No	>9
HHAT-201 ENSP00000416845 ENST00000413764	Q5VTY9 [Direct mapping] Protein-cysteine N-palmitoyltransferase HHAT Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005525 [GTP binding] GO:0005789 [endoplasmic reticulum membrane] GO:0007275 [multicellular organismal development] GO:0016021 [integral component of membrane] GO:1903955 [positive regulation of protein targeting to mitochondrion] Show all	493 aa 57.3 kDa	No	>9
HHAT-202 ENSP00000442625 ENST00000537898	Q5VTY9 [Direct mapping] Protein-cysteine N-palmitoyltransferase HHAT Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005525 [GTP binding] GO:0005789 [endoplasmic reticulum membrane] GO:0007275 [multicellular organismal development] GO:0016021 [integral component of membrane] GO:1903955 [positive regulation of protein targeting to mitochondrion] Show all	428 aa 49.9 kDa	No	>9
HHAT-203 ENSP00000444995 ENST00000541565	Q5VTY9 [Direct mapping] Protein-cysteine N-palmitoyltransferase HHAT Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005525 [GTP binding] GO:0005789 [endoplasmic reticulum membrane] GO:0007275 [multicellular organismal development] GO:0016021 [integral component of membrane] GO:1903955 [positive regulation of protein targeting to mitochondrion] Show all	356 aa 41.1 kDa	No	8
HHAT-204 ENSP00000438468 ENST00000545154	Q5VTY9 [Direct mapping] Protein-cysteine N-palmitoyltransferase HHAT Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005525 [GTP binding] GO:0005789 [endoplasmic reticulum membrane] GO:0007224 [smoothened signaling pathway] GO:0007275 [multicellular organismal development] GO:0016021 [integral component of membrane] GO:0016409 [palmitoyltransferase activity] GO:0018345 [protein palmitoylation] GO:1903955 [positive regulation of protein targeting to mitochondrion] Show all	494 aa 57 kDa	No	>9
HHAT-205 ENSP00000439229 ENST00000545781	F5H2Y1 [Direct mapping] Protein-cysteine N-palmitoyltransferase HHAT Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0016021 [integral component of membrane] Show all	82 aa 9.3 kDa	No	0

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The Human Protein Atlas

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