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KIF1B

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GENERAL INFORMATION

Gene name

 KIF1B

Gene description

 Kinesin family member 1B

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the cytosol & nucleoli (fibrillar center).

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoli fibrillar center (uncertain), Cytosol (uncertain)

DATA RELIABILITY

Reliability score

 Uncertain based on 1 antibody.
CAB015177
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the cytosol & nucleoli (fibrillar center).

Main location

 Nucleoli fibrillar center (uncertain), Cytosol (uncertain)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
CAB015177 A-431 Nucleoli fibrillar center
Cytosol
CAB015177 U-2 OS Nucleoli fibrillar center
Cytosol
CAB015177 U-251 MG Nucleoli fibrillar center
Cytosol

GENE INFORMATION

Gene name

 KIF1B (HGNC Symbol)

Synonyms

 CMT2, CMT2A, HMSNII, KIAA0591, KLP

Description

 Kinesin family member 1B (HGNC Symbol)

Entrez gene summary

 This gene encodes a motor protein that transports mitochondria and synaptic vesicle precursors. Mutations in this gene cause Charcot-Marie-Tooth disease, type 2A1. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p36.22

Chromosome location (bp)

 10210805 - 10381603

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000054523 (version 83.38)

Entrez gene

 23095

UniProt

 O60333 (UniProt - Evidence at protein level)

neXtProt

 NX_O60333

Antibodypedia

 KIF1B antibodies

PROTEIN BROWSER
KIF1B-001
KIF1B-002
KIF1B-003
KIF1B-004
KIF1B-005
KIF1B-011
KIF1B-201
KIF1B-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KIF1B-001
ENSP00000366290
ENST00000377086
O60333 [Direct mapping]
Kinesin-like protein KIF1B
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003777 [microtubule motor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005739 [mitochondrion]
GO:0005871 [kinesin complex]
GO:0005874 [microtubule]
GO:0005875 [microtubule associated complex]
GO:0006915 [apoptotic process]
GO:0007018 [microtubule-based movement]
GO:0007270 [neuron-neuron synaptic transmission]
GO:0007274 [neuromuscular synaptic transmission]
GO:0008017 [microtubule binding]
GO:0008089 [anterograde axon cargo transport]
GO:0008152 [metabolic process]
GO:0008574 [ATP-dependent microtubule motor activity, plus-end-directed]
GO:0016192 [vesicle-mediated transport]
GO:0016887 [ATPase activity]
GO:0019894 [kinesin binding]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0030705 [cytoskeleton-dependent intracellular transport]
GO:0031410 [cytoplasmic vesicle]
GO:0043005 [neuron projection]
Show all
 1816 aa
204.5 kDa 		No 0
KIF1B-002
ENSP00000263934
ENST00000263934
O60333 [Direct mapping]
Kinesin-like protein KIF1B
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003777 [microtubule motor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005739 [mitochondrion]
GO:0005871 [kinesin complex]
GO:0005874 [microtubule]
GO:0005875 [microtubule associated complex]
GO:0006915 [apoptotic process]
GO:0007018 [microtubule-based movement]
GO:0007270 [neuron-neuron synaptic transmission]
GO:0007274 [neuromuscular synaptic transmission]
GO:0008017 [microtubule binding]
GO:0008089 [anterograde axon cargo transport]
GO:0008152 [metabolic process]
GO:0008574 [ATP-dependent microtubule motor activity, plus-end-directed]
GO:0016192 [vesicle-mediated transport]
GO:0016887 [ATPase activity]
GO:0019894 [kinesin binding]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0030705 [cytoskeleton-dependent intracellular transport]
GO:0031410 [cytoplasmic vesicle]
GO:0043005 [neuron projection]
GO:0047497 [mitochondrion transport along microtubule]
Show all
 1770 aa
199.3 kDa 		No 0
KIF1B-003
ENSP00000366297
ENST00000377093
O60333 [Direct mapping]
Kinesin-like protein KIF1B
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003777 [microtubule motor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005739 [mitochondrion]
GO:0005871 [kinesin complex]
GO:0005874 [microtubule]
GO:0005875 [microtubule associated complex]
GO:0006915 [apoptotic process]
GO:0007018 [microtubule-based movement]
GO:0007270 [neuron-neuron synaptic transmission]
GO:0007274 [neuromuscular synaptic transmission]
GO:0008017 [microtubule binding]
GO:0008089 [anterograde axon cargo transport]
GO:0008152 [metabolic process]
GO:0008574 [ATP-dependent microtubule motor activity, plus-end-directed]
GO:0016192 [vesicle-mediated transport]
GO:0016887 [ATPase activity]
GO:0019894 [kinesin binding]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0030705 [cytoskeleton-dependent intracellular transport]
GO:0031410 [cytoplasmic vesicle]
GO:0043005 [neuron projection]
Show all
 1153 aa
130.4 kDa 		No 0
KIF1B-004
ENSP00000366287
ENST00000377083
O60333 [Direct mapping]
Kinesin-like protein KIF1B
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003777 [microtubule motor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005739 [mitochondrion]
GO:0005871 [kinesin complex]
GO:0005874 [microtubule]
GO:0005875 [microtubule associated complex]
GO:0006915 [apoptotic process]
GO:0007018 [microtubule-based movement]
GO:0007270 [neuron-neuron synaptic transmission]
GO:0007274 [neuromuscular synaptic transmission]
GO:0008017 [microtubule binding]
GO:0008089 [anterograde axon cargo transport]
GO:0008152 [metabolic process]
GO:0008574 [ATP-dependent microtubule motor activity, plus-end-directed]
GO:0016192 [vesicle-mediated transport]
GO:0016887 [ATPase activity]
GO:0019894 [kinesin binding]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0030705 [cytoskeleton-dependent intracellular transport]
GO:0031410 [cytoplasmic vesicle]
GO:0043005 [neuron projection]
Show all
 1153 aa
130.4 kDa 		No 0
KIF1B-005
ENSP00000366284
ENST00000377081
O60333 [Direct mapping]
Kinesin-like protein KIF1B
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003777 [microtubule motor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005739 [mitochondrion]
GO:0005871 [kinesin complex]
GO:0005874 [microtubule]
GO:0005875 [microtubule associated complex]
GO:0006915 [apoptotic process]
GO:0007018 [microtubule-based movement]
GO:0007270 [neuron-neuron synaptic transmission]
GO:0007274 [neuromuscular synaptic transmission]
GO:0008017 [microtubule binding]
GO:0008089 [anterograde axon cargo transport]
GO:0008152 [metabolic process]
GO:0008574 [ATP-dependent microtubule motor activity, plus-end-directed]
GO:0016192 [vesicle-mediated transport]
GO:0016887 [ATPase activity]
GO:0019894 [kinesin binding]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0030705 [cytoskeleton-dependent intracellular transport]
GO:0031410 [cytoplasmic vesicle]
GO:0043005 [neuron projection]
Show all
 1823 aa
205.1 kDa 		No 0
KIF1B-011
ENSP00000489057
ENST00000635499
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 498 aa
55.8 kDa 		No 0
KIF1B-201
ENSP00000478500
ENST00000620295
Q4R9M9 [Direct mapping]
Kinesin-like protein
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003777 [microtubule motor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005871 [kinesin complex]
GO:0005874 [microtubule]
GO:0007018 [microtubule-based movement]
GO:0008017 [microtubule binding]
GO:0008152 [metabolic process]
GO:0008574 [ATP-dependent microtubule motor activity, plus-end-directed]
GO:0016192 [vesicle-mediated transport]
GO:0030705 [cytoskeleton-dependent intracellular transport]
Show all
 1809 aa
203.6 kDa 		No 0
KIF1B-202
ENSP00000480063
ENST00000622724
A0A087WWA3 [Direct mapping]
Kinesin-like protein
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003777 [microtubule motor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005871 [kinesin complex]
GO:0005874 [microtubule]
GO:0007018 [microtubule-based movement]
GO:0008017 [microtubule binding]
GO:0008152 [metabolic process]
GO:0008574 [ATP-dependent microtubule motor activity, plus-end-directed]
GO:0016192 [vesicle-mediated transport]
GO:0030705 [cytoskeleton-dependent intracellular transport]
Show all
 1797 aa
202 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.