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KCNH2

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GENERAL INFORMATION

Gene name

 KCNH2

Gene description

 Potassium channel, voltage gated eag related subfamily H, member 2

Protein class

 Disease related genes
FDA approved drug targets
Plasma proteins
Predicted membrane proteins
Transporters
Voltage-gated ion channels

Predicted localization

 Membrane

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Group enriched (K-562, SH-SY5Y, NB-4)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (K-562, SH-SY5Y, NB-4)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 KCNH2 (HGNC Symbol)

Synonyms

 erg1, HERG, Kv11.1, LQT2

Description

 Potassium channel, voltage gated eag related subfamily H, member 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a voltage-activated potassium channel belonging to the eag family. It shares sequence similarity with the Drosophila ether-a-go-go (eag) gene. Mutations in this gene can cause long QT syndrome type 2 (LQT2). Transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

Chromosome

 7

Cytoband

 q36.1

Chromosome location (bp)

 150944961 - 150978315

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000055118 (version 83.38)

Entrez gene

 3757

UniProt

 Q12809 (UniProt - Evidence at protein level)

neXtProt

 NX_Q12809

Antibodypedia

 KCNH2 antibodies

PROTEIN BROWSER
KCNH2-001
KCNH2-004
KCNH2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KCNH2-001
ENSP00000262186
ENST00000262186
Q12809 [Direct mapping]
Potassium voltage-gated channel subfamily H member 2
A0A090N8Q0 [Target identity:100%; Query identity:100%]
Potassium voltage-gated channel, subfamily H (Eag-related), member 2
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Voltage-Gated Potassium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Plasma proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0000155 [phosphorelay sensor kinase activity]
GO:0000160 [phosphorelay signal transduction system]
GO:0003064 [regulation of heart rate by hormone]
GO:0005216 [ion channel activity]
GO:0005242 [inward rectifier potassium channel activity]
GO:0005249 [voltage-gated potassium channel activity]
GO:0005251 [delayed rectifier potassium channel activity]
GO:0005515 [protein binding]
GO:0005635 [nuclear envelope]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0007268 [synaptic transmission]
GO:0008076 [voltage-gated potassium channel complex]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0031625 [ubiquitin protein ligase binding]
GO:0035690 [cellular response to drug]
GO:0042391 [regulation of membrane potential]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0055075 [potassium ion homeostasis]
GO:0055085 [transmembrane transport]
GO:0055131 [C3HC4-type RING finger domain binding]
GO:0060048 [cardiac muscle contraction]
GO:0060306 [regulation of membrane repolarization]
GO:0060307 [regulation of ventricular cardiac muscle cell membrane repolarization]
GO:0071435 [potassium ion export]
GO:0071805 [potassium ion transmembrane transport]
GO:0086005 [ventricular cardiac muscle cell action potential]
GO:0086008 [voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization]
GO:0086010 [membrane depolarization during action potential]
GO:0086011 [membrane repolarization during action potential]
GO:0086013 [membrane repolarization during cardiac muscle cell action potential]
GO:0086091 [regulation of heart rate by cardiac conduction]
GO:0097110 [scaffold protein binding]
GO:0097623 [potassium ion export across plasma membrane]
GO:1901379 [regulation of potassium ion transmembrane transport]
GO:1901380 [negative regulation of potassium ion transmembrane transport]
GO:1901381 [positive regulation of potassium ion transmembrane transport]
GO:1902282 [voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization]
GO:1902303 [negative regulation of potassium ion export]
Show all
 1159 aa
126.7 kDa 		No 5
KCNH2-004
ENSP00000328531
ENST00000330883
Q12809 [Direct mapping]
Potassium voltage-gated channel subfamily H member 2
A0A090N7X5 [Target identity:100%; Query identity:100%]
Potassium voltage-gated channel, subfamily H (Eag-related), member 2
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Voltage-Gated Potassium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Plasma proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Show all
GO:0000155 [phosphorelay sensor kinase activity]
GO:0000160 [phosphorelay signal transduction system]
GO:0003064 [regulation of heart rate by hormone]
GO:0005216 [ion channel activity]
GO:0005242 [inward rectifier potassium channel activity]
GO:0005249 [voltage-gated potassium channel activity]
GO:0005251 [delayed rectifier potassium channel activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0007268 [synaptic transmission]
GO:0008076 [voltage-gated potassium channel complex]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0031625 [ubiquitin protein ligase binding]
GO:0035690 [cellular response to drug]
GO:0042391 [regulation of membrane potential]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0055075 [potassium ion homeostasis]
GO:0055085 [transmembrane transport]
GO:0055131 [C3HC4-type RING finger domain binding]
GO:0060048 [cardiac muscle contraction]
GO:0060306 [regulation of membrane repolarization]
GO:0060307 [regulation of ventricular cardiac muscle cell membrane repolarization]
GO:0071435 [potassium ion export]
GO:0071805 [potassium ion transmembrane transport]
GO:0086005 [ventricular cardiac muscle cell action potential]
GO:0086008 [voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization]
GO:0086010 [membrane depolarization during action potential]
GO:0086011 [membrane repolarization during action potential]
GO:0086013 [membrane repolarization during cardiac muscle cell action potential]
GO:0086091 [regulation of heart rate by cardiac conduction]
GO:0097110 [scaffold protein binding]
GO:0097623 [potassium ion export across plasma membrane]
GO:1901379 [regulation of potassium ion transmembrane transport]
GO:1901380 [negative regulation of potassium ion transmembrane transport]
GO:1901381 [positive regulation of potassium ion transmembrane transport]
GO:1902282 [voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization]
GO:1902303 [negative regulation of potassium ion export]
Show all
 819 aa
90.1 kDa 		No 5
KCNH2-201
ENSP00000387657
ENST00000430723
Q86U57 [Direct mapping]
Potassium voltage-gated channel subfamily H member 2; Potassium voltage-gated channel, subfamily H (Eag-related), member 2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Show all
GO:0000155 [phosphorelay sensor kinase activity]
GO:0000160 [phosphorelay signal transduction system]
GO:0005216 [ion channel activity]
GO:0005249 [voltage-gated potassium channel activity]
GO:0005622 [intracellular]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0016020 [membrane]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0055085 [transmembrane transport]
GO:0071805 [potassium ion transmembrane transport]
Show all
 772 aa
85.2 kDa 		No 5

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.