Cell atlas - KMT2C - The Human Protein Atlas

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KMT2C

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	KMT2C
Gene description	Lysine (K)-specific methyltransferase 2C
Protein class	Cancer-related genes Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA074736
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoplasm.

Main location

Nucleoplasm (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA074736	MCF7	Nucleoplasm
	HPA074736	RH-30	Nucleoplasm
	HPA074736	U-2 OS	Nucleoplasm

GENE INFORMATION
Gene name	KMT2C (HGNC Symbol)
Synonyms	HALR, KIAA1506, MLL3
Description	Lysine (K)-specific methyltransferase 2C (HGNC Symbol)
Entrez gene summary	This gene is a member of the myeloid/lymphoid or mixed-lineage leukemia (MLL) family and encodes a nuclear protein with an AT hook DNA-binding domain, a DHHC-type zinc finger, six PHD-type zinc fingers, a SET domain, a post-SET domain and a RING-type zinc finger. This protein is a member of the ASC-2/NCOA6 complex (ASCOM), which possesses histone methylation activity and is involved in transcriptional coactivation. [provided by RefSeq, Jul 2008]
Chromosome	7
Cytoband	q36.1
Chromosome location (bp)	152134922 - 152436005
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000055609 (version 83.38)
Entrez gene	58508
UniProt	Q8NEZ4 (UniProt - Evidence at protein level)
neXtProt	NX_Q8NEZ4
Antibodypedia	KMT2C antibodies

PROTEIN BROWSER

KMT2C-001	KMT2C-008	KMT2C-009	KMT2C-010	KMT2C-013	KMT2C-015	KMT2C-017	KMT2C-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KMT2C-001 ENSP00000262189 ENST00000262189	Q8NEZ4 [Direct mapping] Histone-lysine N-methyltransferase 2C Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Plasma proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006325 [chromatin organization] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007338 [single fertilization] GO:0008270 [zinc ion binding] GO:0010468 [regulation of gene expression] GO:0035097 [histone methyltransferase complex] GO:0035264 [multicellular organism growth] GO:0035556 [intracellular signal transduction] GO:0042800 [histone methyltransferase activity (H3-K4 specific)] GO:0044822 [poly(A) RNA binding] GO:0048146 [positive regulation of fibroblast proliferation] GO:0051568 [histone H3-K4 methylation] GO:0061029 [eyelid development in camera-type eye] Show all	4911 aa 541.4 kDa	No	0
KMT2C-008 ENSP00000403483 ENST00000418673	H7C212 [Direct mapping] Histone-lysine N-methyltransferase 2C Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0008270 [zinc ion binding] Show all	228 aa 24.4 kDa	No	0
KMT2C-009 ENSP00000353218 ENST00000360104	H7BY37 [Direct mapping] Histone-lysine N-methyltransferase 2C Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0008270 [zinc ion binding] Show all	2441 aa 269.5 kDa	No	0
KMT2C-010 ENSP00000410411 ENST00000424877	H0Y765 [Direct mapping] Histone-lysine N-methyltransferase 2C Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0008168 [methyltransferase activity] GO:0008270 [zinc ion binding] GO:0032259 [methylation] Show all	1524 aa 168.5 kDa	No	0
KMT2C-013 ENSP00000410239 ENST00000452749	C9J4Z5 [Direct mapping] Histone-lysine N-methyltransferase 2C Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0006355 [regulation of transcription, DNA-templated] Show all	155 aa 16.8 kDa	No	0
KMT2C-015 ENSP00000408001 ENST00000418061	H7C2V8 [Direct mapping] Histone-lysine N-methyltransferase 2C Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations Protein evidence (Ezkurdia et al 2014) Show all		236 aa 25 kDa	No	0
KMT2C-017 ENSP00000454058 ENST00000558665	H0YNL4 [Direct mapping] Histone-lysine N-methyltransferase 2C Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations Protein evidence (Ezkurdia et al 2014) Show all		179 aa 19.8 kDa	No	0
KMT2C-201 ENSP00000347325 ENST00000355193	Q8NEZ4 [Direct mapping] Histone-lysine N-methyltransferase 2C Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Plasma proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006325 [chromatin organization] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0035097 [histone methyltransferase complex] GO:0035556 [intracellular signal transduction] GO:0042800 [histone methyltransferase activity (H3-K4 specific)] GO:0044822 [poly(A) RNA binding] GO:0051568 [histone H3-K4 methylation] Show all	4911 aa 541.4 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.