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MRPL43

GENERAL INFORMATION

Gene name

 MRPL43

Gene description

 Mitochondrial ribosomal protein L43

Protein class

 Predicted intracellular proteins
Ribosomal proteins

Predicted localization

 Intracellular

Number of transcripts

 11
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 MRPL43 (HGNC Symbol)

Synonyms

 bMRP36a

Description

 Mitochondrial ribosomal protein L43 (HGNC Symbol)

Entrez gene summary

 Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. This gene and the gene for a semaphorin class 4 protein (SEMA4G) overlap at map location 10q24.31 and are transcribed in opposite directions. Sequence analysis identified multiple transcript variants encoding at least four different protein isoforms. [provided by RefSeq, Jul 2008]

Chromosome

 10

Cytoband

 q24.31

Chromosome location (bp)

 100969458 - 100987515

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000055950 (version 83.38)

Entrez gene

 84545

UniProt

 Q8N983 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8N983

Antibodypedia

 MRPL43 antibodies

PROTEIN BROWSER
«
MRPL43-001
MRPL43-002
MRPL43-004
MRPL43-006
MRPL43-007
MRPL43-008
MRPL43-009
MRPL43-010
MRPL43-012
MRPL43-013
MRPL43-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MRPL43-001
ENSP00000359254
ENST00000370234
Q8N983 [Direct mapping]
39S ribosomal protein L43, mitochondrial
Show all
Ribosomal proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003735 [structural constituent of ribosome]
GO:0005515 [protein binding]
GO:0005743 [mitochondrial inner membrane]
GO:0005761 [mitochondrial ribosome]
GO:0005762 [mitochondrial large ribosomal subunit]
GO:0006412 [translation]
GO:0006996 [organelle organization]
GO:0032543 [mitochondrial translation]
GO:0044822 [poly(A) RNA binding]
GO:0070124 [mitochondrial translational initiation]
GO:0070125 [mitochondrial translational elongation]
GO:0070126 [mitochondrial translational termination]
Show all
 164 aa
18.3 kDa 		No 0
MRPL43-002
ENSP00000315364
ENST00000318325
Q8N983 [Direct mapping]
39S ribosomal protein L43, mitochondrial
Show all
Ribosomal proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003735 [structural constituent of ribosome]
GO:0005515 [protein binding]
GO:0005743 [mitochondrial inner membrane]
GO:0005761 [mitochondrial ribosome]
GO:0005762 [mitochondrial large ribosomal subunit]
GO:0006412 [translation]
GO:0006996 [organelle organization]
GO:0032543 [mitochondrial translation]
GO:0044822 [poly(A) RNA binding]
GO:0070124 [mitochondrial translational initiation]
GO:0070125 [mitochondrial translational elongation]
GO:0070126 [mitochondrial translational termination]
Show all
 215 aa
23.4 kDa 		No 0
MRPL43-004
ENSP00000315948
ENST00000318364
Q8N983 [Direct mapping]
39S ribosomal protein L43, mitochondrial
Show all
Ribosomal proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003735 [structural constituent of ribosome]
GO:0005515 [protein binding]
GO:0005743 [mitochondrial inner membrane]
GO:0005761 [mitochondrial ribosome]
GO:0005762 [mitochondrial large ribosomal subunit]
GO:0006412 [translation]
GO:0006996 [organelle organization]
GO:0032543 [mitochondrial translation]
GO:0044822 [poly(A) RNA binding]
GO:0070124 [mitochondrial translational initiation]
GO:0070125 [mitochondrial translational elongation]
GO:0070126 [mitochondrial translational termination]
Show all
 159 aa
17.9 kDa 		No 0
MRPL43-006
ENSP00000359262
ENST00000370242
Q8N983 [Direct mapping]
39S ribosomal protein L43, mitochondrial
Show all
Ribosomal proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003735 [structural constituent of ribosome]
GO:0005515 [protein binding]
GO:0005743 [mitochondrial inner membrane]
GO:0005761 [mitochondrial ribosome]
GO:0005762 [mitochondrial large ribosomal subunit]
GO:0006412 [translation]
GO:0006996 [organelle organization]
GO:0032543 [mitochondrial translation]
GO:0044822 [poly(A) RNA binding]
GO:0070124 [mitochondrial translational initiation]
GO:0070125 [mitochondrial translational elongation]
GO:0070126 [mitochondrial translational termination]
Show all
 261 aa
28.7 kDa 		No 0
MRPL43-007
ENSP00000299179
ENST00000299179
Q8N983 [Direct mapping]
39S ribosomal protein L43, mitochondrial
Show all
Ribosomal proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003735 [structural constituent of ribosome]
GO:0005515 [protein binding]
GO:0005743 [mitochondrial inner membrane]
GO:0005761 [mitochondrial ribosome]
GO:0005762 [mitochondrial large ribosomal subunit]
GO:0006412 [translation]
GO:0006996 [organelle organization]
GO:0032543 [mitochondrial translation]
GO:0044822 [poly(A) RNA binding]
GO:0070124 [mitochondrial translational initiation]
GO:0070125 [mitochondrial translational elongation]
GO:0070126 [mitochondrial translational termination]
Show all
 202 aa
22.6 kDa 		No 0
MRPL43-008
ENSP00000359261
ENST00000370241
B1AL05 [Direct mapping]
39S ribosomal protein L43, mitochondrial
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 184 aa
20.5 kDa 		No 0
MRPL43-009
ENSP00000408806
ENST00000448244
H0Y6Y8 [Direct mapping]
39S ribosomal protein L43, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 169 aa
18.7 kDa 		No 0
MRPL43-010
ENSP00000471004
ENST00000477279
M0R051 [Direct mapping]
39S ribosomal protein L43, mitochondrial
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 44 aa
4.7 kDa 		No 0
MRPL43-012
ENSP00000359256
ENST00000370236
Q8N983 [Direct mapping]
39S ribosomal protein L43, mitochondrial
Show all
Ribosomal proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003735 [structural constituent of ribosome]
GO:0005515 [protein binding]
GO:0005743 [mitochondrial inner membrane]
GO:0005761 [mitochondrial ribosome]
GO:0005762 [mitochondrial large ribosomal subunit]
GO:0006412 [translation]
GO:0006996 [organelle organization]
GO:0032543 [mitochondrial translation]
GO:0044822 [poly(A) RNA binding]
GO:0070124 [mitochondrial translational initiation]
GO:0070125 [mitochondrial translational elongation]
GO:0070126 [mitochondrial translational termination]
Show all
 159 aa
17.9 kDa 		No 0
MRPL43-013
ENSP00000430369
ENST00000523148
H0YBU8 [Direct mapping]
39S ribosomal protein L43, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 148 aa
16.6 kDa 		No 0
MRPL43-201
ENSP00000339844
ENST00000342071
Q8N983 [Direct mapping]
39S ribosomal protein L43, mitochondrial
Show all
Ribosomal proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003735 [structural constituent of ribosome]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005761 [mitochondrial ribosome]
GO:0005762 [mitochondrial large ribosomal subunit]
GO:0006412 [translation]
GO:0006996 [organelle organization]
GO:0032543 [mitochondrial translation]
GO:0044822 [poly(A) RNA binding]
GO:0070124 [mitochondrial translational initiation]
GO:0070125 [mitochondrial translational elongation]
GO:0070126 [mitochondrial translational termination]
Show all
 235 aa
25.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.