Tissue expression of ITIH4 - Summary - The Human Protein Atlas

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ITIH4

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TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	ITIH4
Gene description	Inter-alpha-trypsin inhibitor heavy chain family, member 4
Protein class	Cancer-related genes Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (liver)
GTEx:	Tissue enhanced (liver)
FANTOM5:	Tissue enriched (liver)

Protein evidence

Evidence at protein level

Protein expression

Plasma positivity, expression in liver.

DATA RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Presumed off target binding observed and disregarded.
Reliability score	Supported based on 3 antibodies. HPA001835 , HPA003948 , CAB072872
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (liver)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (liver)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (liver)

GENE INFORMATION
Gene name	ITIH4 (HGNC Symbol)
Synonyms	H4P, IHRP, ITIHL1
Description	Inter-alpha-trypsin inhibitor heavy chain family, member 4 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is secreted into the blood, where it is cleaved by plasma kallikrein into two smaller forms. Expression of this gene has been detected only in liver, and it seems to be upregulated during surgical trauma. This gene is part of a cluster of similar genes on chromosome 3. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Chromosome	3
Cytoband	p21.1
Chromosome location (bp)	52812975 - 52831479
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000055955 (version 83.38)
Entrez gene	3700
UniProt	Q14624 (UniProt - Evidence at protein level)
neXtProt	NX_Q14624
Antibodypedia	ITIH4 antibodies

PROTEIN BROWSER

ITIH4-001	ITIH4-005	ITIH4-018	ITIH4-021

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ITIH4-001 ENSP00000266041 ENST00000266041	Q14624 [Direct mapping] Inter-alpha-trypsin inhibitor heavy chain H4 70 kDa inter-alpha-trypsin inhibitor heavy chain H4 35 kDa inter-alpha-trypsin inhibitor heavy chain H4 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004866 [endopeptidase inhibitor activity] GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006953 [acute-phase response] GO:0010951 [negative regulation of endopeptidase activity] GO:0030212 [hyaluronan metabolic process] GO:0034097 [response to cytokine] GO:0070062 [extracellular exosome] GO:0072562 [blood microparticle] Show all	930 aa 103.4 kDa	Yes	0
ITIH4-005 ENSP00000384425 ENST00000406595	Q14624 [Direct mapping] Inter-alpha-trypsin inhibitor heavy chain H4 70 kDa inter-alpha-trypsin inhibitor heavy chain H4 35 kDa inter-alpha-trypsin inhibitor heavy chain H4 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004866 [endopeptidase inhibitor activity] GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0006953 [acute-phase response] GO:0010951 [negative regulation of endopeptidase activity] GO:0030212 [hyaluronan metabolic process] GO:0034097 [response to cytokine] GO:0070062 [extracellular exosome] GO:0072562 [blood microparticle] Show all	900 aa 99.9 kDa	Yes	0
ITIH4-018 ENSP00000395634 ENST00000441637	H7C0L5 [Direct mapping] Inter-alpha-trypsin inhibitor heavy chain H4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0010951 [negative regulation of endopeptidase activity] GO:0030212 [hyaluronan metabolic process] Show all	719 aa 80 kDa	No	0
ITIH4-021 ENSP00000417824 ENST00000485816	B7ZKJ8 [Direct mapping] ITIH4 protein; Inter-alpha-trypsin inhibitor heavy chain H4 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0010951 [negative regulation of endopeptidase activity] GO:0030212 [hyaluronan metabolic process] Show all	935 aa 103.9 kDa	Yes	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.