Cell atlas - PHF21B - The Human Protein Atlas

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PHF21B

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoli fibrillar center
	Nucleus

Human cell
	Nucleoli
	Nucleoplasm

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GENERAL INFORMATION
Gene name	PHF21B
Gene description	PHD finger protein 21B
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleus & nucleoli (fibrillar center).
RNA cell category	Cell line enhanced (SH-SY5Y, AF22, SCLC-21H)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (uncertain), Nucleoli fibrillar center (uncertain)

DATA RELIABILITY
Reliability score	Uncertain based on 1 antibody. HPA053834
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SH-SY5Y, AF22, SCLC-21H) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleus & nucleoli (fibrillar center).

Main location

Nucleus (uncertain), Nucleoli fibrillar center (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA053834	RT4	Nucleus
	HPA053834	RT4	Nucleoli fibrillar center
	HPA053834	SH-SY5Y	Nucleus
			Nucleoli fibrillar center
			Cytosol
	HPA053834	U-2 OS	Nucleus
	HPA053834	U-2 OS	Nucleoli fibrillar center

GENE INFORMATION
Gene name	PHF21B (HGNC Symbol)
Synonyms	BHC80L, FLJ34161, PHF4
Description	PHD finger protein 21B (HGNC Symbol)
Entrez gene summary
Chromosome	22
Cytoband	q13.31
Chromosome location (bp)	44881162 - 45009999
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000056487 (version 83.38)
Entrez gene	112885
UniProt	Q96EK2 (UniProt - Evidence at transcript level)
neXtProt	NX_Q96EK2
Antibodypedia	PHF21B antibodies

PROTEIN BROWSER

PHF21B-001	PHF21B-003	PHF21B-008	PHF21B-010	PHF21B-012	PHF21B-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PHF21B-001 ENSP00000324403 ENST00000313237	Q96EK2 [Direct mapping] PHD finger protein 21B Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0003682 [chromatin binding] GO:0003712 [transcription cofactor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0042393 [histone binding] Show all	531 aa 57.5 kDa	No	0
PHF21B-003 ENSP00000385053 ENST00000403565	B1AHC5 [Direct mapping] PHD finger protein 21B; PHD finger protein 21B, isoform CRA_c; cDNA FLJ34161 fis, clone FCBBF3014229, highly similar to PHD finger protein 21B Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0008270 [zinc ion binding] Show all	327 aa 36.4 kDa	No	0
PHF21B-008 ENSP00000401294 ENST00000420689	B0QYW2 [Direct mapping] PHD finger protein 21B Show all	Predicted intracellular proteins Show all		192 aa 19.8 kDa	No	0
PHF21B-010 ENSP00000401091 ENST00000414269	B1AHC6 [Direct mapping] PHD finger protein 21B Show all	Predicted intracellular proteins Show all		137 aa 15.2 kDa	No	0
PHF21B-012 ENSP00000487086 ENST00000629843	Q96EK2 [Direct mapping] PHD finger protein 21B Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0003682 [chromatin binding] GO:0003712 [transcription cofactor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0042393 [histone binding] Show all	489 aa 53 kDa	No	0
PHF21B-201 ENSP00000379410 ENST00000396103	Q96EK2 [Direct mapping] PHD finger protein 21B Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0003682 [chromatin binding] GO:0003712 [transcription cofactor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0042393 [histone binding] Show all	477 aa 51.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.