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RC3H2

GENERAL INFORMATION

Gene name

 RC3H2

Gene description

 Ring finger and CCCH-type domains 2

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA042863
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA042863

GENE INFORMATION

Gene name

 RC3H2 (HGNC Symbol)

Synonyms

 FLJ20301, FLJ20713, MNAB, RNF164

Description

 Ring finger and CCCH-type domains 2 (HGNC Symbol)

Entrez gene summary

Chromosome

 9

Cytoband

 q33.2

Chromosome location (bp)

 122844556 - 122905341

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000056586 (version 83.38)

Entrez gene

 54542

UniProt

 Q9HBD1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9HBD1

Antibodypedia

 RC3H2 antibodies

PROTEIN BROWSER
RC3H2-001
RC3H2-002
RC3H2-006
RC3H2-007
RC3H2-008
RC3H2-010
RC3H2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RC3H2-001
ENSP00000362774
ENST00000373670
Q9HBD1 [Direct mapping]
Roquin-2
A0A024R899 [Target identity:100%; Query identity:100%]
Membrane associated DNA binding protein, isoform CRA_a
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Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209 [protein polyubiquitination]
GO:0000932 [cytoplasmic mRNA processing body]
GO:0001782 [B cell homeostasis]
GO:0003677 [DNA binding]
GO:0003729 [mRNA binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0008270 [zinc ion binding]
GO:0009791 [post-embryonic development]
GO:0009986 [cell surface]
GO:0010468 [regulation of gene expression]
GO:0010608 [posttranscriptional regulation of gene expression]
GO:0016020 [membrane]
GO:0016874 [ligase activity]
GO:0035264 [multicellular organism growth]
GO:0042098 [T cell proliferation]
GO:0043029 [T cell homeostasis]
GO:0044822 [poly(A) RNA binding]
GO:0046872 [metal ion binding]
GO:0048286 [lung alveolus development]
GO:0048535 [lymph node development]
GO:0048536 [spleen development]
GO:0060173 [limb development]
GO:0061470 [T follicular helper cell differentiation]
GO:1901224 [positive regulation of NIK/NF-kappaB signaling]
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 1191 aa
131.7 kDa 		No 0
RC3H2-002
ENSP00000411767
ENST00000423239
Q9HBD1 [Direct mapping]
Roquin-2
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   Phobius predicted membrane proteins
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209 [protein polyubiquitination]
GO:0000932 [cytoplasmic mRNA processing body]
GO:0003677 [DNA binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0008270 [zinc ion binding]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016874 [ligase activity]
GO:0044822 [poly(A) RNA binding]
GO:0046872 [metal ion binding]
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 1064 aa
117.9 kDa 		No 0
RC3H2-006
ENSP00000474148
ENST00000471874
Q9HBD1 [Direct mapping]
Roquin-2
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   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209 [protein polyubiquitination]
GO:0000932 [cytoplasmic mRNA processing body]
GO:0003677 [DNA binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0008270 [zinc ion binding]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016874 [ligase activity]
GO:0044822 [poly(A) RNA binding]
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 218 aa
24.3 kDa 		No 0
RC3H2-007
ENSP00000335150
ENST00000335387
A6NHN2 [Direct mapping]
Roquin-2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0008270 [zinc ion binding]
GO:0046872 [metal ion binding]
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 506 aa
56.8 kDa 		No 0
RC3H2-008
ENSP00000398081
ENST00000454740
H0Y5D9 [Direct mapping]
Roquin-2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 188 aa
21.1 kDa 		No 0
RC3H2-010
ENSP00000381663
ENST00000398671
Q4VXB2 [Direct mapping]
Roquin-2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 111 aa
12.2 kDa 		No 0
RC3H2-201
ENSP00000349783
ENST00000357244
Q9HBD1 [Direct mapping]
Roquin-2
A0A024R899 [Target identity:100%; Query identity:100%]
Membrane associated DNA binding protein, isoform CRA_a
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209 [protein polyubiquitination]
GO:0000932 [cytoplasmic mRNA processing body]
GO:0003677 [DNA binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0008270 [zinc ion binding]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016874 [ligase activity]
GO:0044822 [poly(A) RNA binding]
GO:0046872 [metal ion binding]
Show all
 1191 aa
131.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.