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IL17RB

GENERAL INFORMATION

Gene name

 IL17RB

Gene description

 Interleukin 17 receptor B

Protein class

 Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (kidney)
GTEx:Expressed in all
FANTOM5:Tissue enhanced (kidney)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in liver and kidney.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 1 antibody.
HPA005482
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Duodenum
N/A
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Adrenal gland

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (kidney)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (kidney)

GENE INFORMATION

Gene name

 IL17RB (HGNC Symbol)

Synonyms

 CRL4, EVI27, IL17BR, IL17RH1

Description

 Interleukin 17 receptor B (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a cytokine receptor. This receptor specifically binds to IL17B and IL17E, but does not bind to IL17 and IL17C. This receptor has been shown to mediate the activation of NF-kappaB and the production of IL8 induced by IL17E. The expression of the rat counterpart of this gene was found to be significantly up-regulated during intestinal inflammation, which suggested the immunoregulatory activity of this receptor. [provided by RefSeq, Jul 2008]

Chromosome

 3

Cytoband

 p21.1

Chromosome location (bp)

 53846580 - 53865800

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000056736 (version 83.38)

Entrez gene

 55540

UniProt

 Q9NRM6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NRM6

Antibodypedia

 IL17RB antibodies

PROTEIN BROWSER
IL17RB-001
IL17RB-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IL17RB-001
ENSP00000288167
ENST00000288167
Q9NRM6 [Direct mapping]
Interleukin-17 receptor B
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0001558 [regulation of cell growth]
GO:0004896 [cytokine receptor activity]
GO:0005576 [extracellular region]
GO:0005737 [cytoplasm]
GO:0005887 [integral component of plasma membrane]
GO:0006952 [defense response]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030368 [interleukin-17 receptor activity]
GO:0050729 [positive regulation of inflammatory response]
GO:2000664 [positive regulation of interleukin-5 secretion]
GO:2000667 [positive regulation of interleukin-13 secretion]
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 502 aa
55.9 kDa 		Yes 1
IL17RB-004
ENSP00000418638
ENST00000494338
C9IZN0 [Direct mapping]
Interleukin-17 receptor B
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0016021 [integral component of membrane]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030368 [interleukin-17 receptor activity]
Show all
 348 aa
38.6 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.