Cell atlas - SOAT1 - The Human Protein Atlas

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SOAT1

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TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Endoplasmic reticulum

Human cell
	Endoplasmic Reticulum

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GENERAL INFORMATION
Gene name	SOAT1
Gene description	Sterol O-acyltransferase 1
Protein class	Enzymes FDA approved drug targets Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the endoplasmic reticulum.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Endoplasmic reticulum (validated)

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. CAB009533 , HPA047171
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the endoplasmic reticulum.

Main location

Endoplasmic reticulum (validated)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA047171	A-431	Endoplasmic reticulum
	HPA047171	U-2 OS	No staining
	HPA047171	U-251 MG	Endoplasmic reticulum
	CAB009533	A-431	Endoplasmic reticulum
	CAB009533	U-2 OS	Endoplasmic reticulum
	CAB009533	U-251 MG	Nuclear bodies
	CAB009533	U-251 MG	Endoplasmic reticulum

GENE INFORMATION
Gene name	SOAT1 (HGNC Symbol)
Synonyms	ACAT, SOAT, STAT
Description	Sterol O-acyltransferase 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the acyltransferase family. It is located in the endoplasmic reticulum, and catalyzes the formation of fatty acid-cholesterol esters. This gene has been implicated in the formation of beta-amyloid and atherosclerotic plaques by controlling the equilibrium between free cholesterol and cytoplasmic cholesteryl esters. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2011]
Chromosome	1
Cytoband	q25.2
Chromosome location (bp)	179293714 - 179358680
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000057252 (version 83.38)
Entrez gene	6646
UniProt	P35610 (UniProt - Evidence at protein level)
neXtProt	NX_P35610
Antibodypedia	SOAT1 antibodies

PROTEIN BROWSER

SOAT1-001	SOAT1-002	SOAT1-201	SOAT1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SOAT1-001 ENSP00000356591 ENST00000367619	P35610 [Direct mapping] Sterol O-acyltransferase 1 Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000062 [fatty-acyl-CoA binding] GO:0004772 [sterol O-acyltransferase activity] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0008203 [cholesterol metabolic process] GO:0008374 [O-acyltransferase activity] GO:0010742 [macrophage derived foam cell differentiation] GO:0010878 [cholesterol storage] GO:0015485 [cholesterol binding] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0033344 [cholesterol efflux] GO:0034379 [very-low-density lipoprotein particle assembly] GO:0034435 [cholesterol esterification] GO:0034736 [cholesterol O-acyltransferase activity] GO:0042632 [cholesterol homeostasis] GO:0042986 [positive regulation of amyloid precursor protein biosynthetic process] Show all	550 aa 64.7 kDa	No	9
SOAT1-002 ENSP00000411309 ENST00000426956	B1APM4 [Direct mapping] Sterol O-acyltransferase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005783 [endoplasmic reticulum] GO:0008152 [metabolic process] GO:0008374 [O-acyltransferase activity] GO:0016021 [integral component of membrane] Show all	260 aa 29.9 kDa	No	3
SOAT1-201 ENSP00000441356 ENST00000539888	P35610 [Direct mapping] Sterol O-acyltransferase 1 Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000062 [fatty-acyl-CoA binding] GO:0004772 [sterol O-acyltransferase activity] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0008203 [cholesterol metabolic process] GO:0008374 [O-acyltransferase activity] GO:0010742 [macrophage derived foam cell differentiation] GO:0010878 [cholesterol storage] GO:0015485 [cholesterol binding] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0033344 [cholesterol efflux] GO:0034379 [very-low-density lipoprotein particle assembly] GO:0034435 [cholesterol esterification] GO:0034736 [cholesterol O-acyltransferase activity] GO:0042632 [cholesterol homeostasis] GO:0042986 [positive regulation of amyloid precursor protein biosynthetic process] Show all	485 aa 57.2 kDa	No	7
SOAT1-202 ENSP00000445315 ENST00000540564	P35610 [Direct mapping] Sterol O-acyltransferase 1 Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000062 [fatty-acyl-CoA binding] GO:0004772 [sterol O-acyltransferase activity] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0008203 [cholesterol metabolic process] GO:0008374 [O-acyltransferase activity] GO:0010742 [macrophage derived foam cell differentiation] GO:0010878 [cholesterol storage] GO:0015485 [cholesterol binding] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0033344 [cholesterol efflux] GO:0034379 [very-low-density lipoprotein particle assembly] GO:0034435 [cholesterol esterification] GO:0034736 [cholesterol O-acyltransferase activity] GO:0042632 [cholesterol homeostasis] GO:0042986 [positive regulation of amyloid precursor protein biosynthetic process] Show all	492 aa 58.1 kDa	No	7

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.