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F7

GENERAL INFORMATION

Gene name

 F7

Gene description

 Coagulation factor VII (serum prothrombin conversion accelerator)

Protein class

 Candidate cardiovascular disease genes
Disease related genes
Enzymes
FDA approved drug targets
Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (liver cancer)
HPA (cell line):Group enriched (CACO-2, Hep G2)
HPA (normal tissue):Tissue enriched (liver)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 F7

Synonyms

Description

 Coagulation factor VII (serum prothrombin conversion accelerator) (HGNC Symbol)

Entrez gene summary

 This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Defects in this gene can cause coagulopathy. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing to generate mature polypeptides. [provided by RefSeq, Aug 2015]

Chromosome

 13

Cytoband

 q34

Chromosome location (bp)

 113105788 - 113120681

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000057593 (version 83.38)

Entrez gene

 2155

UniProt

 P08709 (UniProt - Evidence at protein level)

neXtProt

 NX_P08709

Antibodypedia

 F7 antibodies

PROTEIN BROWSER
F7-001
F7-002
F7-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
F7-001
ENSP00000364731
ENST00000375581
P08709 [Direct mapping]
Coagulation factor VII Factor VII light chain Factor VII heavy chain
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Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Serine-type peptidases
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001948 [glycoprotein binding]
GO:0002690 [positive regulation of leukocyte chemotaxis]
GO:0004175 [endopeptidase activity]
GO:0004252 [serine-type endopeptidase activity]
GO:0005102 [receptor binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005796 [Golgi lumen]
GO:0005886 [plasma membrane]
GO:0006508 [proteolysis]
GO:0007596 [blood coagulation]
GO:0007598 [blood coagulation, extrinsic pathway]
GO:0007623 [circadian rhythm]
GO:0008236 [serine-type peptidase activity]
GO:0009725 [response to hormone]
GO:0010641 [positive regulation of platelet-derived growth factor receptor signaling pathway]
GO:0014070 [response to organic cyclic compound]
GO:0017187 [peptidyl-glutamic acid carboxylation]
GO:0030194 [positive regulation of blood coagulation]
GO:0030335 [positive regulation of cell migration]
GO:0031100 [organ regeneration]
GO:0031667 [response to nutrient levels]
GO:0031982 [vesicle]
GO:0032571 [response to vitamin K]
GO:0043627 [response to estrogen]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0050927 [positive regulation of positive chemotaxis]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0060416 [response to growth hormone]
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 466 aa
51.6 kDa 		Yes 0
F7-002
ENSP00000329546
ENST00000346342
P08709 [Direct mapping]
Coagulation factor VII Factor VII light chain Factor VII heavy chain
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Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Serine-type peptidases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001948 [glycoprotein binding]
GO:0002690 [positive regulation of leukocyte chemotaxis]
GO:0004252 [serine-type endopeptidase activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005796 [Golgi lumen]
GO:0005886 [plasma membrane]
GO:0006508 [proteolysis]
GO:0007596 [blood coagulation]
GO:0007598 [blood coagulation, extrinsic pathway]
GO:0007623 [circadian rhythm]
GO:0008236 [serine-type peptidase activity]
GO:0010641 [positive regulation of platelet-derived growth factor receptor signaling pathway]
GO:0017187 [peptidyl-glutamic acid carboxylation]
GO:0030335 [positive regulation of cell migration]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0050927 [positive regulation of positive chemotaxis]
GO:0051897 [positive regulation of protein kinase B signaling]
Show all
 444 aa
49.3 kDa 		Yes 0
F7-201
ENSP00000442051
ENST00000541084
F5H8B0 [Direct mapping]
Coagulation factor VII
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   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004252 [serine-type endopeptidase activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0006508 [proteolysis]
GO:0007596 [blood coagulation]
Show all
 382 aa
41.9 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.