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PRDM1

GENERAL INFORMATION

Gene name

 PRDM1

Gene description

 PR domain containing 1, with ZNF domain

Protein class

 Cancer-related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (esophagus)
GTEx:Tissue enhanced (esophagus)
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear expression in squamous epithelium.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 1 antibody.
HPA030033
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Esophagus

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (esophagus)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (esophagus)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 PRDM1 (HGNC Symbol)

Synonyms

 BLIMP1, PRDI-BF1

Description

 PR domain containing 1, with ZNF domain (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that acts as a repressor of beta-interferon gene expression. The protein binds specifically to the PRDI (positive regulatory domain I element) of the beta-IFN gene promoter. Transcription of this gene increases upon virus induction. Two alternatively spliced transcript variants that encode different isoforms have been reported. [provided by RefSeq, Jul 2008]

Chromosome

 6

Cytoband

 q21

Chromosome location (bp)

 106086320 - 106109939

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000057657 (version 83.38)

Entrez gene

 639

UniProt

 O75626 (UniProt - Evidence at protein level)

neXtProt

 NX_O75626

Antibodypedia

 PRDM1 antibodies

PROTEIN BROWSER
PRDM1-001
PRDM1-002
PRDM1-004
PRDM1-006
PRDM1-007
PRDM1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PRDM1-001
ENSP00000358092
ENST00000369096
O75626 [Direct mapping]
PR domain zinc finger protein 1
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Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   Mutated cancer genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Large Deletions
   COSMIC Frameshift Mutations
Protein evidence (Kim et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001701 [in utero embryonic development]
GO:0001763 [morphogenesis of a branching structure]
GO:0001892 [embryonic placenta development]
GO:0001893 [maternal placenta development]
GO:0003170 [heart valve development]
GO:0003279 [cardiac septum development]
GO:0003281 [ventricular septum development]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0007281 [germ cell development]
GO:0008168 [methyltransferase activity]
GO:0009791 [post-embryonic development]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0030889 [negative regulation of B cell proliferation]
GO:0031665 [negative regulation of lipopolysaccharide-mediated signaling pathway]
GO:0032259 [methylation]
GO:0035904 [aorta development]
GO:0042127 [regulation of cell proliferation]
GO:0042462 [eye photoreceptor cell development]
GO:0042826 [histone deacetylase binding]
GO:0043565 [sequence-specific DNA binding]
GO:0045165 [cell fate commitment]
GO:0045579 [positive regulation of B cell differentiation]
GO:0046872 [metal ion binding]
GO:0048844 [artery morphogenesis]
GO:0048869 [cellular developmental process]
GO:0060576 [intestinal epithelial cell development]
GO:0060707 [trophoblast giant cell differentiation]
GO:0060976 [coronary vasculature development]
GO:1990654 [sebum secreting cell proliferation]
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 825 aa
91.8 kDa 		No 0
PRDM1-002
ENSP00000358085
ENST00000369089
O75626 [Direct mapping]
PR domain zinc finger protein 1
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   Mutated cancer genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Large Deletions
   COSMIC Frameshift Mutations
Protein evidence (Kim et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0008168 [methyltransferase activity]
GO:0032259 [methylation]
GO:0046872 [metal ion binding]
GO:0048869 [cellular developmental process]
Show all
 691 aa
76.8 kDa 		No 0
PRDM1-004
ENSP00000358087
ENST00000369091
O75626 [Direct mapping]
PR domain zinc finger protein 1
Q5T4E8 [Target identity:100%; Query identity:100%]
PR domain containing 1, with ZNF domain; PR domain containing 1, with ZNF domain, isoform CRA_b
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Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   Mutated cancer genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Large Deletions
   COSMIC Frameshift Mutations
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0008168 [methyltransferase activity]
GO:0032259 [methylation]
GO:0046872 [metal ion binding]
GO:0048869 [cellular developmental process]
Show all
 789 aa
88 kDa 		No 0
PRDM1-006
ENSP00000395566
ENST00000424894
B2REA5 [Direct mapping]
PR domain zinc finger protein 1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Large Deletions
   COSMIC Frameshift Mutations
Show all
 63 aa
7.1 kDa 		No 0
PRDM1-007
ENSP00000399772
ENST00000450060
B2REA4 [Direct mapping]
PR domain zinc finger protein 1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Large Deletions
   COSMIC Frameshift Mutations
Show all
GO:0005515 [protein binding]
Show all
 171 aa
20 kDa 		No 0
PRDM1-201
ENSP00000478294
ENST00000613999
A0A087WU16 [Direct mapping]
PR domain zinc finger protein 1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Large Deletions
   COSMIC Frameshift Mutations
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003676 [nucleic acid binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0046872 [metal ion binding]
GO:0048869 [cellular developmental process]
Show all
 788 aa
87.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.