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ATG5

GENERAL INFORMATION

Gene name

 ATG5

Gene description

 Autophagy related 5

Protein class

 Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA042973 , CAB034432 , CAB037309
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA042973
CAB034432
CAB037309

GENE INFORMATION

Gene name

 ATG5 (HGNC Symbol)

Synonyms

 APG5, APG5L, ASP, hAPG5

Description

 Autophagy related 5 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene, in combination with autophagy protein 12, functions as an E1-like activating enzyme in a ubiquitin-like conjugating system. The encoded protein is involved in several cellular processes, including autophagic vesicle formation, mitochondrial quality control after oxidative damage, negative regulation of the innate antiviral immune response, lymphocyte development and proliferation, MHC II antigen presentation, adipocyte differentiation, and apoptosis. Several transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

Chromosome

 6

Cytoband

 q21

Chromosome location (bp)

 106184476 - 106325820

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000057663 (version 83.38)

Entrez gene

 9474

UniProt

 Q9H1Y0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H1Y0

Antibodypedia

 ATG5 antibodies

PROTEIN BROWSER
ATG5-001
ATG5-002
ATG5-003
ATG5-201
ATG5-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ATG5-001
ENSP00000358072
ENST00000369076
Q9H1Y0 [Direct mapping]
Autophagy protein 5
A9UGY9 [Target identity:100%; Query identity:100%]
Autophagy protein 5
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000422 [mitophagy]
GO:0000423 [macromitophagy]
GO:0001974 [blood vessel remodeling]
GO:0002739 [regulation of cytokine secretion involved in immune response]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005776 [autophagosome]
GO:0005829 [cytosol]
GO:0005930 [axoneme]
GO:0006501 [C-terminal protein lipidation]
GO:0006914 [autophagy]
GO:0006915 [apoptotic process]
GO:0006995 [cellular response to nitrogen starvation]
GO:0009620 [response to fungus]
GO:0016020 [membrane]
GO:0016236 [macroautophagy]
GO:0019776 [Atg8 ligase activity]
GO:0030670 [phagocytic vesicle membrane]
GO:0031397 [negative regulation of protein ubiquitination]
GO:0032480 [negative regulation of type I interferon production]
GO:0034045 [pre-autophagosomal structure membrane]
GO:0034274 [Atg12-Atg5-Atg16 complex]
GO:0039689 [negative stranded viral RNA replication]
GO:0042311 [vasodilation]
GO:0042493 [response to drug]
GO:0043066 [negative regulation of apoptotic process]
GO:0043687 [post-translational protein modification]
GO:0044233 [ER-mitochondrion membrane contact site]
GO:0044804 [nucleophagy]
GO:0045087 [innate immune response]
GO:0048840 [otolith development]
GO:0051279 [regulation of release of sequestered calcium ion into cytosol]
GO:0055015 [ventricular cardiac muscle cell development]
GO:0060047 [heart contraction]
GO:0070257 [positive regulation of mucus secretion]
GO:1902017 [regulation of cilium assembly]
GO:1903599 [positive regulation of mitophagy]
GO:2000377 [regulation of reactive oxygen species metabolic process]
GO:2000378 [negative regulation of reactive oxygen species metabolic process]
GO:2000619 [negative regulation of histone H4-K16 acetylation]
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 275 aa
32.4 kDa 		No 0
ATG5-002
ENSP00000343313
ENST00000343245
Q9H1Y0 [Direct mapping]
Autophagy protein 5
A9UGY9 [Target identity:100%; Query identity:100%]
Autophagy protein 5
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000422 [mitophagy]
GO:0000423 [macromitophagy]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005776 [autophagosome]
GO:0005829 [cytosol]
GO:0005930 [axoneme]
GO:0006501 [C-terminal protein lipidation]
GO:0006914 [autophagy]
GO:0006915 [apoptotic process]
GO:0006995 [cellular response to nitrogen starvation]
GO:0016020 [membrane]
GO:0016236 [macroautophagy]
GO:0019776 [Atg8 ligase activity]
GO:0030670 [phagocytic vesicle membrane]
GO:0032480 [negative regulation of type I interferon production]
GO:0034045 [pre-autophagosomal structure membrane]
GO:0034274 [Atg12-Atg5-Atg16 complex]
GO:0043687 [post-translational protein modification]
GO:0044804 [nucleophagy]
GO:0045087 [innate immune response]
GO:1902017 [regulation of cilium assembly]
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 275 aa
32.4 kDa 		No 0
ATG5-003
ENSP00000358066
ENST00000369070
Q9H1Y0 [Direct mapping]
Autophagy protein 5
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000422 [mitophagy]
GO:0000423 [macromitophagy]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005776 [autophagosome]
GO:0005829 [cytosol]
GO:0005930 [axoneme]
GO:0006501 [C-terminal protein lipidation]
GO:0006914 [autophagy]
GO:0006915 [apoptotic process]
GO:0006995 [cellular response to nitrogen starvation]
GO:0016020 [membrane]
GO:0016236 [macroautophagy]
GO:0019776 [Atg8 ligase activity]
GO:0030670 [phagocytic vesicle membrane]
GO:0032480 [negative regulation of type I interferon production]
GO:0034045 [pre-autophagosomal structure membrane]
GO:0034274 [Atg12-Atg5-Atg16 complex]
GO:0043687 [post-translational protein modification]
GO:0044804 [nucleophagy]
GO:0045087 [innate immune response]
GO:1902017 [regulation of cilium assembly]
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 197 aa
22.9 kDa 		Yes 0
ATG5-201
ENSP00000353884
ENST00000360666
Q7Z3H3 [Direct mapping]
Autophagy protein 5; Putative uncharacterized protein DKFZp686F0183
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000422 [mitophagy]
GO:0006501 [C-terminal protein lipidation]
GO:0006995 [cellular response to nitrogen starvation]
GO:0019776 [Atg8 ligase activity]
GO:0034045 [pre-autophagosomal structure membrane]
GO:0034274 [Atg12-Atg5-Atg16 complex]
GO:0044804 [nucleophagy]
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 91 aa
10.9 kDa 		No 0
ATG5-202
ENSP00000483135
ENST00000613993
L7UQJ2 [Direct mapping]
Autophagy protein 5
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000422 [mitophagy]
GO:0005737 [cytoplasm]
GO:0006501 [C-terminal protein lipidation]
GO:0006914 [autophagy]
GO:0006995 [cellular response to nitrogen starvation]
GO:0019776 [Atg8 ligase activity]
GO:0034045 [pre-autophagosomal structure membrane]
GO:0034274 [Atg12-Atg5-Atg16 complex]
GO:0044804 [nucleophagy]
Show all
 162 aa
19.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.