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USP13

GENERAL INFORMATION

Gene name

 USP13

Gene description

 Ubiquitin specific peptidase 13 (isopeptidase T-3)

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Uncertain based on 1 antibody.
HPA004827
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), liver cancer (unfavourable) and urothelial cancer (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
Urothelial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA004827

GENE INFORMATION

Gene name

 USP13 (HGNC Symbol)

Synonyms

 IsoT-3

Description

 Ubiquitin specific peptidase 13 (isopeptidase T-3) (HGNC Symbol)

Entrez gene summary

Chromosome

 3

Cytoband

 q26.33

Chromosome location (bp)

 179652755 - 179789401

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000058056 (version 83.38)

Entrez gene

 8975

UniProt

 Q92995 (UniProt - Evidence at protein level)

neXtProt

 NX_Q92995

Antibodypedia

 USP13 antibodies

PROTEIN BROWSER
USP13-001
USP13-003
USP13-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
USP13-001
ENSP00000263966
ENST00000263966
Q92995 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 13
A0A0A6YZ17 [Target identity:100%; Query identity:100%]
Ubiquitin carboxyl-terminal hydrolase
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Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0004197 [cysteine-type endopeptidase activity]
GO:0004843 [ubiquitin-specific protease activity]
GO:0005515 [protein binding]
GO:0005764 [lysosome]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0006914 [autophagy]
GO:0008242 [omega peptidase activity]
GO:0008270 [zinc ion binding]
GO:0008283 [cell proliferation]
GO:0010506 [regulation of autophagy]
GO:0016579 [protein deubiquitination]
GO:0030318 [melanocyte differentiation]
GO:0031625 [ubiquitin protein ligase binding]
GO:0036459 [ubiquitinyl hydrolase activity]
GO:0043130 [ubiquitin binding]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0044389 [ubiquitin-like protein ligase binding]
GO:0050821 [protein stabilization]
GO:0051087 [chaperone binding]
GO:0061136 [regulation of proteasomal protein catabolic process]
GO:0070536 [protein K63-linked deubiquitination]
GO:0070628 [proteasome binding]
GO:1904288 [BAT3 complex binding]
GO:1904294 [positive regulation of ERAD pathway]
GO:1904378 [maintenance of unfolded protein involved in ERAD pathway]
GO:1904454 [ubiquitin-specific protease activity involved in positive regulation of ERAD pathway]
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 863 aa
97.3 kDa 		No 0
USP13-003
ENSP00000417146
ENST00000496897
Q92995 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 13
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Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0004843 [ubiquitin-specific protease activity]
GO:0005515 [protein binding]
GO:0005764 [lysosome]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0006914 [autophagy]
GO:0008242 [omega peptidase activity]
GO:0008270 [zinc ion binding]
GO:0008283 [cell proliferation]
GO:0010506 [regulation of autophagy]
GO:0016579 [protein deubiquitination]
GO:0030318 [melanocyte differentiation]
GO:0031625 [ubiquitin protein ligase binding]
GO:0036459 [ubiquitinyl hydrolase activity]
GO:0043130 [ubiquitin binding]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0044389 [ubiquitin-like protein ligase binding]
GO:0050821 [protein stabilization]
GO:0051087 [chaperone binding]
GO:0061136 [regulation of proteasomal protein catabolic process]
GO:0070536 [protein K63-linked deubiquitination]
GO:0070628 [proteasome binding]
GO:1904288 [BAT3 complex binding]
GO:1904294 [positive regulation of ERAD pathway]
GO:1904378 [maintenance of unfolded protein involved in ERAD pathway]
GO:1904454 [ubiquitin-specific protease activity involved in positive regulation of ERAD pathway]
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 798 aa
90.4 kDa 		No 0
USP13-006
ENSP00000420057
ENST00000497155
H7C5J3 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 13
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005764 [lysosome]
GO:0016579 [protein deubiquitination]
GO:0036459 [ubiquitinyl hydrolase activity]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0061136 [regulation of proteasomal protein catabolic process]
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 299 aa
34.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.