Expression of ATP11B in cancer - Summary - The Human Protein Atlas

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ATP11B

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ATP11B
Gene description	ATPase, class VI, type 11B
Protein class	Enzymes Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in a few tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA036237 , HPA036238
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (unfavourable) and endometrial cancer (unfavourable).
Pancreatic cancer p<0.001 Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA036237	HPA036238

GENE INFORMATION
Gene name	ATP11B (HGNC Symbol)
Synonyms	ATPIF, ATPIR, KIAA0956
Description	ATPase, class VI, type 11B (HGNC Symbol)
Entrez gene summary	P-type ATPases, such as ATP11B, are phosphorylated in their intermediate state and drive uphill transport of ions across membranes. Several subfamilies of P-type ATPases have been identified. One subfamily transports heavy metal ions, such as Cu(2+) or Cd(2+). Another subfamily transports non-heavy metal ions, such as H(+), Na(+), K(+), or Ca(+). A third subfamily transports amphipaths, such as phosphatidylserine.[supplied by OMIM, Feb 2005]
Chromosome	3
Cytoband	q26.33
Chromosome location (bp)	182793500 - 182921635
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000058063 (version 83.38)
Entrez gene	23200
UniProt	Q9Y2G3 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y2G3
Antibodypedia	ATP11B antibodies

PROTEIN BROWSER

ATP11B-001	ATP11B-002	ATP11B-004	ATP11B-007	ATP11B-009	ATP11B-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ATP11B-001 ENSP00000321195 ENST00000323116	Q9Y2G3 [Direct mapping] Probable phospholipid-transporting ATPase IF Show all	Enzymes ENZYME proteins Hydrolases Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0000287 [magnesium ion binding] GO:0004012 [phospholipid-translocating ATPase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005637 [nuclear inner membrane] GO:0005769 [early endosome] GO:0005783 [endoplasmic reticulum] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0006811 [ion transport] GO:0008152 [metabolic process] GO:0015075 [ion transmembrane transporter activity] GO:0015914 [phospholipid transport] GO:0015917 [aminophospholipid transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] GO:0045332 [phospholipid translocation] GO:0046872 [metal ion binding] GO:0055037 [recycling endosome] GO:0055038 [recycling endosome membrane] GO:0055085 [transmembrane transport] Show all	1177 aa 134.2 kDa	No	>9
ATP11B-002 ENSP00000419032 ENST00000493826	A0A0C4DG94 [Direct mapping] Probable phospholipid-transporting ATPase IF Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0000287 [magnesium ion binding] GO:0004012 [phospholipid-translocating ATPase activity] GO:0005524 [ATP binding] GO:0005886 [plasma membrane] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0045332 [phospholipid translocation] GO:0046872 [metal ion binding] Show all	195 aa 22.5 kDa	No	2
ATP11B-004 ENSP00000418421 ENST00000498086	H7C4W6 [Direct mapping] Phospholipid-transporting ATPase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0000287 [magnesium ion binding] GO:0004012 [phospholipid-translocating ATPase activity] GO:0005524 [ATP binding] GO:0005886 [plasma membrane] GO:0008152 [metabolic process] GO:0015914 [phospholipid transport] GO:0016021 [integral component of membrane] GO:0045332 [phospholipid translocation] Show all	970 aa 111 kDa	No	8
ATP11B-007 ENSP00000419768 ENST00000491699	H0Y8C7 [Direct mapping] Probable phospholipid-transporting ATPase IF Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0004012 [phospholipid-translocating ATPase activity] GO:0005524 [ATP binding] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0045332 [phospholipid translocation] Show all	147 aa 16.6 kDa	No	2
ATP11B-009 ENSP00000417124 ENST00000482070	H7C4E6 [Direct mapping] Probable phospholipid-transporting ATPase IF Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0004012 [phospholipid-translocating ATPase activity] GO:0005524 [ATP binding] GO:0005886 [plasma membrane] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0045332 [phospholipid translocation] Show all	238 aa 27.1 kDa	No	5
ATP11B-011 ENSP00000419152 ENST00000484691	H7C575 [Direct mapping] Probable phospholipid-transporting ATPase IF Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0004012 [phospholipid-translocating ATPase activity] GO:0005524 [ATP binding] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0045332 [phospholipid translocation] Show all	119 aa 13.6 kDa	No	1

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