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POLR3E

GENERAL INFORMATION

Gene name

 POLR3E

Gene description

 Polymerase (RNA) III (DNA directed) polypeptide E (80kD)

Protein class

 Predicted intracellular proteins
RNA polymerase related proteins

Predicted localization

 Intracellular

Number of transcripts

 9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous expression in nucleus.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 1 antibody.
HPA041477
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PROGNOSTIC SUMMARY
Prognostic marker in prostate cancer (unfavourable).
Prostate cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA041477

GENE INFORMATION

Gene name

 POLR3E (HGNC Symbol)

Synonyms

 FLJ10509, RPC5, SIN

Description

 Polymerase (RNA) III (DNA directed) polypeptide E (80kD) (HGNC Symbol)

Entrez gene summary

Chromosome

 16

Cytoband

 p12.2

Chromosome location (bp)

 22297375 - 22335103

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000058600 (version 83.38)

Entrez gene

 55718

UniProt

 Q9NVU0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NVU0

Antibodypedia

 POLR3E antibodies

PROTEIN BROWSER
POLR3E-001
POLR3E-002
POLR3E-003
POLR3E-004
POLR3E-009
POLR3E-012
POLR3E-013
POLR3E-015
POLR3E-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
POLR3E-001
ENSP00000299853
ENST00000299853
Q9NVU0 [Direct mapping]
DNA-directed RNA polymerase III subunit RPC5
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Predicted intracellular proteins
RNA polymerase related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001056 [RNA polymerase III activity]
GO:0003899 [DNA-directed RNA polymerase activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005666 [DNA-directed RNA polymerase III complex]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006383 [transcription from RNA polymerase III promoter]
GO:0006385 [transcription elongation from RNA polymerase III promoter]
GO:0006386 [termination of RNA polymerase III transcription]
GO:0010467 [gene expression]
GO:0032481 [positive regulation of type I interferon production]
GO:0045087 [innate immune response]
GO:0051607 [defense response to virus]
Show all
 708 aa
79.9 kDa 		No 0
POLR3E-002
ENSP00000456967
ENST00000564209
Q9NVU0 [Direct mapping]
DNA-directed RNA polymerase III subunit RPC5
Show all
Predicted intracellular proteins
RNA polymerase related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001056 [RNA polymerase III activity]
GO:0003899 [DNA-directed RNA polymerase activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005666 [DNA-directed RNA polymerase III complex]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006383 [transcription from RNA polymerase III promoter]
GO:0006385 [transcription elongation from RNA polymerase III promoter]
GO:0006386 [termination of RNA polymerase III transcription]
GO:0010467 [gene expression]
GO:0032481 [positive regulation of type I interferon production]
GO:0045087 [innate immune response]
GO:0051607 [defense response to virus]
Show all
 687 aa
77.2 kDa 		No 0
POLR3E-003
ENSP00000399254
ENST00000418581
Q9NVU0 [Direct mapping]
DNA-directed RNA polymerase III subunit RPC5
Show all
Predicted intracellular proteins
RNA polymerase related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001056 [RNA polymerase III activity]
GO:0003899 [DNA-directed RNA polymerase activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005666 [DNA-directed RNA polymerase III complex]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006383 [transcription from RNA polymerase III promoter]
GO:0006385 [transcription elongation from RNA polymerase III promoter]
GO:0006386 [termination of RNA polymerase III transcription]
GO:0010467 [gene expression]
GO:0032481 [positive regulation of type I interferon production]
GO:0045087 [innate immune response]
GO:0051607 [defense response to virus]
Show all
 672 aa
75.8 kDa 		No 0
POLR3E-004
ENSP00000352140
ENST00000359210
Q9NVU0 [Direct mapping]
DNA-directed RNA polymerase III subunit RPC5
Show all
Predicted intracellular proteins
RNA polymerase related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001056 [RNA polymerase III activity]
GO:0003899 [DNA-directed RNA polymerase activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005666 [DNA-directed RNA polymerase III complex]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006383 [transcription from RNA polymerase III promoter]
GO:0006385 [transcription elongation from RNA polymerase III promoter]
GO:0006386 [termination of RNA polymerase III transcription]
GO:0010467 [gene expression]
GO:0032481 [positive regulation of type I interferon production]
GO:0045087 [innate immune response]
GO:0051607 [defense response to virus]
Show all
 666 aa
74.8 kDa 		No 0
POLR3E-009
ENSP00000456454
ENST00000563024
H3BRY1 [Direct mapping]
DNA-directed RNA polymerase III subunit RPC5
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Predicted intracellular proteins
RNA polymerase related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001056 [RNA polymerase III activity]
GO:0003899 [DNA-directed RNA polymerase activity]
GO:0005634 [nucleus]
GO:0005813 [centrosome]
GO:0006351 [transcription, DNA-templated]
GO:0006383 [transcription from RNA polymerase III promoter]
Show all
 99 aa
11 kDa 		No 0
POLR3E-012
ENSP00000454507
ENST00000565358
H3BMR4 [Direct mapping]
DNA-directed RNA polymerase III subunit RPC5
Show all
Predicted intracellular proteins
RNA polymerase related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001056 [RNA polymerase III activity]
GO:0003899 [DNA-directed RNA polymerase activity]
GO:0005634 [nucleus]
GO:0005813 [centrosome]
GO:0006351 [transcription, DNA-templated]
GO:0006383 [transcription from RNA polymerase III promoter]
Show all
 139 aa
15.8 kDa 		No 0
POLR3E-013
ENSP00000456718
ENST00000564883
H3BSI5 [Direct mapping]
DNA-directed RNA polymerase III subunit RPC5
Show all
Predicted intracellular proteins
RNA polymerase related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001056 [RNA polymerase III activity]
GO:0003899 [DNA-directed RNA polymerase activity]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006383 [transcription from RNA polymerase III promoter]
Show all
 110 aa
12.4 kDa 		No 0
POLR3E-015
ENSP00000454875
ENST00000569757
H3BNJ0 [Direct mapping]
DNA-directed RNA polymerase III subunit RPC5
Show all
Predicted intracellular proteins
RNA polymerase related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001056 [RNA polymerase III activity]
GO:0003899 [DNA-directed RNA polymerase activity]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006383 [transcription from RNA polymerase III promoter]
Show all
 90 aa
10 kDa 		No 0
POLR3E-201
ENSP00000484648
ENST00000615879
A0A0C4DH01 [Direct mapping]
DNA-directed RNA polymerase III subunit RPC5
Show all
Predicted intracellular proteins
RNA polymerase related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001056 [RNA polymerase III activity]
GO:0003899 [DNA-directed RNA polymerase activity]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006383 [transcription from RNA polymerase III promoter]
Show all
 672 aa
75.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.