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ATP2B4

GENERAL INFORMATION

Gene name

 ATP2B4

Gene description

 ATPase, Ca++ transporting, plasma membrane 4

Protein class

 Enzymes
Predicted intracellular proteins
Predicted membrane proteins
Transporters

Predicted localization

 Intracellular,Membrane

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous membranous expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA040431 , CAB016118
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Endometrial cancer

STAINING SUMMARY
HPA040431
CAB016118

GENE INFORMATION

Gene name

 ATP2B4 (HGNC Symbol)

Synonyms

 ATP2B2, MXRA1, PMCA4

Description

 ATPase, Ca++ transporting, plasma membrane 4 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 4. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 q32.1

Chromosome location (bp)

 203626561 - 203744081

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000058668 (version 83.38)

Entrez gene

 493

UniProt

 P23634 (UniProt - Evidence at protein level)

neXtProt

 NX_P23634

Antibodypedia

 ATP2B4 antibodies

PROTEIN BROWSER
ATP2B4-001
ATP2B4-002
ATP2B4-004
ATP2B4-006
ATP2B4-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ATP2B4-001
ENSP00000350310
ENST00000357681
P23634 [Direct mapping]
Plasma membrane calcium-transporting ATPase 4
A0A024R968 [Target identity:100%; Query identity:100%]
Calcium-transporting ATPase
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Enzymes
   ENZYME proteins
   Hydrolases
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003407 [neural retina development]
GO:0005388 [calcium-transporting ATPase activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005901 [caveola]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006816 [calcium ion transport]
GO:0006874 [cellular calcium ion homeostasis]
GO:0007283 [spermatogenesis]
GO:0007596 [blood coagulation]
GO:0008152 [metabolic process]
GO:0010751 [negative regulation of nitric oxide mediated signal transduction]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0017080 [sodium channel regulator activity]
GO:0021766 [hippocampus development]
GO:0030018 [Z disc]
GO:0030165 [PDZ domain binding]
GO:0030315 [T-tubule]
GO:0030346 [protein phosphatase 2B binding]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0034220 [ion transmembrane transport]
GO:0036487 [nitric-oxide synthase inhibitor activity]
GO:0042383 [sarcolemma]
GO:0043005 [neuron projection]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043234 [protein complex]
GO:0045019 [negative regulation of nitric oxide biosynthetic process]
GO:0046872 [metal ion binding]
GO:0050998 [nitric-oxide synthase binding]
GO:0051001 [negative regulation of nitric-oxide synthase activity]
GO:0051599 [response to hydrostatic pressure]
GO:0055085 [transmembrane transport]
GO:0070588 [calcium ion transmembrane transport]
GO:0070885 [negative regulation of calcineurin-NFAT signaling cascade]
GO:0071872 [cellular response to epinephrine stimulus]
GO:0097110 [scaffold protein binding]
GO:0097228 [sperm principal piece]
GO:0097553 [calcium ion transmembrane import into cytosol]
GO:0098703 [calcium ion import across plasma membrane]
GO:0098736 [negative regulation of the force of heart contraction]
GO:1900082 [negative regulation of arginine catabolic process]
GO:1901205 [negative regulation of adrenergic receptor signaling pathway involved in heart process]
GO:1901660 [calcium ion export]
GO:1902083 [negative regulation of peptidyl-cysteine S-nitrosylation]
GO:1902305 [regulation of sodium ion transmembrane transport]
GO:1902806 [regulation of cell cycle G1/S phase transition]
GO:1903243 [negative regulation of cardiac muscle hypertrophy in response to stress]
GO:1903249 [negative regulation of citrulline biosynthetic process]
GO:2000481 [positive regulation of cAMP-dependent protein kinase activity]
Show all
 1205 aa
133.9 kDa 		No >9
ATP2B4-002
ENSP00000340930
ENST00000341360
P23634 [Direct mapping]
Plasma membrane calcium-transporting ATPase 4
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0005388 [calcium-transporting ATPase activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005901 [caveola]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006874 [cellular calcium ion homeostasis]
GO:0007596 [blood coagulation]
GO:0008152 [metabolic process]
GO:0010751 [negative regulation of nitric oxide mediated signal transduction]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0017080 [sodium channel regulator activity]
GO:0030018 [Z disc]
GO:0030165 [PDZ domain binding]
GO:0030315 [T-tubule]
GO:0030346 [protein phosphatase 2B binding]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0034220 [ion transmembrane transport]
GO:0036487 [nitric-oxide synthase inhibitor activity]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043234 [protein complex]
GO:0045019 [negative regulation of nitric oxide biosynthetic process]
GO:0046872 [metal ion binding]
GO:0050998 [nitric-oxide synthase binding]
GO:0051001 [negative regulation of nitric-oxide synthase activity]
GO:0051599 [response to hydrostatic pressure]
GO:0055085 [transmembrane transport]
GO:0070588 [calcium ion transmembrane transport]
GO:0070885 [negative regulation of calcineurin-NFAT signaling cascade]
GO:0071872 [cellular response to epinephrine stimulus]
GO:0097110 [scaffold protein binding]
GO:0097553 [calcium ion transmembrane import into cytosol]
GO:0098703 [calcium ion import across plasma membrane]
GO:0098736 [negative regulation of the force of heart contraction]
GO:1900082 [negative regulation of arginine catabolic process]
GO:1901205 [negative regulation of adrenergic receptor signaling pathway involved in heart process]
GO:1902083 [negative regulation of peptidyl-cysteine S-nitrosylation]
GO:1902305 [regulation of sodium ion transmembrane transport]
GO:1902806 [regulation of cell cycle G1/S phase transition]
GO:1903243 [negative regulation of cardiac muscle hypertrophy in response to stress]
GO:1903249 [negative regulation of citrulline biosynthetic process]
GO:2000481 [positive regulation of cAMP-dependent protein kinase activity]
Show all
 1170 aa
129.4 kDa 		No >9
ATP2B4-004
ENSP00000391150
ENST00000458092
H7BZS8 [Direct mapping]
Plasma membrane calcium-transporting ATPase 4
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005388 [calcium-transporting ATPase activity]
GO:0005524 [ATP binding]
GO:0016021 [integral component of membrane]
GO:0070588 [calcium ion transmembrane transport]
Show all
 117 aa
13.1 kDa 		No 1
ATP2B4-006
ENSP00000349165
ENST00000356729
H7BY13 [Direct mapping]
Plasma membrane calcium-transporting ATPase 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005388 [calcium-transporting ATPase activity]
GO:0070588 [calcium ion transmembrane transport]
Show all
 129 aa
14 kDa 		No 0
ATP2B4-201
ENSP00000356187
ENST00000367218
P23634 [Direct mapping]
Plasma membrane calcium-transporting ATPase 4
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0005388 [calcium-transporting ATPase activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005901 [caveola]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006874 [cellular calcium ion homeostasis]
GO:0007596 [blood coagulation]
GO:0008152 [metabolic process]
GO:0010751 [negative regulation of nitric oxide mediated signal transduction]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0017080 [sodium channel regulator activity]
GO:0030018 [Z disc]
GO:0030165 [PDZ domain binding]
GO:0030315 [T-tubule]
GO:0030346 [protein phosphatase 2B binding]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0034220 [ion transmembrane transport]
GO:0036487 [nitric-oxide synthase inhibitor activity]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043234 [protein complex]
GO:0045019 [negative regulation of nitric oxide biosynthetic process]
GO:0046872 [metal ion binding]
GO:0050998 [nitric-oxide synthase binding]
GO:0051001 [negative regulation of nitric-oxide synthase activity]
GO:0051599 [response to hydrostatic pressure]
GO:0055085 [transmembrane transport]
GO:0070588 [calcium ion transmembrane transport]
GO:0070885 [negative regulation of calcineurin-NFAT signaling cascade]
GO:0071872 [cellular response to epinephrine stimulus]
GO:0097110 [scaffold protein binding]
GO:0097553 [calcium ion transmembrane import into cytosol]
GO:0098703 [calcium ion import across plasma membrane]
GO:0098736 [negative regulation of the force of heart contraction]
GO:1900082 [negative regulation of arginine catabolic process]
GO:1901205 [negative regulation of adrenergic receptor signaling pathway involved in heart process]
GO:1902083 [negative regulation of peptidyl-cysteine S-nitrosylation]
GO:1902305 [regulation of sodium ion transmembrane transport]
GO:1902806 [regulation of cell cycle G1/S phase transition]
GO:1903243 [negative regulation of cardiac muscle hypertrophy in response to stress]
GO:1903249 [negative regulation of citrulline biosynthetic process]
GO:2000481 [positive regulation of cAMP-dependent protein kinase activity]
Show all
 1170 aa
129.4 kDa 		No >9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.