Expression of PARP12 in cancer - Summary - The Human Protein Atlas

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PARP12

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PARP12
Gene description	Poly (ADP-ribose) polymerase family, member 12
Protein class	Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA003584
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA003584

GENE INFORMATION
Gene name	PARP12 (HGNC Symbol)
Synonyms	FLJ22693, PARP-12, ZC3H1, ZC3HDC1
Description	Poly (ADP-ribose) polymerase family, member 12 (HGNC Symbol)
Entrez gene summary
Chromosome	7
Cytoband	q34
Chromosome location (bp)	140023744 - 140063721
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000059378 (version 83.38)
Entrez gene	64761
UniProt	Q9H0J9 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H0J9
Antibodypedia	PARP12 antibodies

PROTEIN BROWSER

PARP12-001	PARP12-006	PARP12-013

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PARP12-001 ENSP00000263549 ENST00000263549	Q9H0J9 [Direct mapping] Poly [ADP-ribose] polymerase 12 A4D1T0 [Target identity:100%; Query identity:100%] Poly (ADP-ribose) polymerase family, member 12, isoform CRA_b; Zinc finger CCCH type domain containing 1 Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003950 [NAD+ ADP-ribosyltransferase activity] GO:0005634 [nucleus] GO:0008152 [metabolic process] GO:0044822 [poly(A) RNA binding] GO:0046872 [metal ion binding] Show all	701 aa 79.1 kDa	No	0
PARP12-006 ENSP00000417606 ENST00000489809	H7C4L8 [Direct mapping] Poly [ADP-ribose] polymerase 12 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		173 aa 19.4 kDa	No	0
PARP12-013 ENSP00000418640 ENST00000484111	H7C4Z9 [Direct mapping] Poly [ADP-ribose] polymerase 12 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003950 [NAD+ ADP-ribosyltransferase activity] GO:0008152 [metabolic process] Show all	76 aa 8.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.