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GATB

GENERAL INFORMATION

Gene name

 GATB

Gene description

 Glutamyl-tRNA(Gln) amidotransferase, subunit B

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic and membranous expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
HPA042610
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA042610

GENE INFORMATION

Gene name

 GATB (HGNC Symbol)

Synonyms

 PET112, PET112L

Description

 Glutamyl-tRNA(Gln) amidotransferase, subunit B (HGNC Symbol)

Entrez gene summary

Chromosome

 4

Cytoband

 q31.3

Chromosome location (bp)

 151670504 - 151761023

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000059691 (version 83.38)

Entrez gene

 5188

UniProt

 O75879 (UniProt - Evidence at protein level)

neXtProt

 NX_O75879

Antibodypedia

 GATB antibodies

PROTEIN BROWSER
GATB-001
GATB-002
GATB-003
GATB-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GATB-001
ENSP00000263985
ENST00000263985
O75879 [Direct mapping]
Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005524 [ATP binding]
GO:0005739 [mitochondrion]
GO:0006412 [translation]
GO:0008135 [translation factor activity, RNA binding]
GO:0016874 [ligase activity]
GO:0016884 [carbon-nitrogen ligase activity, with glutamine as amido-N-donor]
GO:0030956 [glutamyl-tRNA(Gln) amidotransferase complex]
GO:0032543 [mitochondrial translation]
GO:0050567 [glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity]
GO:0070681 [glutaminyl-tRNAGln biosynthesis via transamidation]
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 557 aa
61.9 kDa 		No 0
GATB-002
ENSP00000426859
ENST00000515812
D6REA0 [Direct mapping]
Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005739 [mitochondrion]
GO:0008152 [metabolic process]
GO:0016874 [ligase activity]
GO:0016884 [carbon-nitrogen ligase activity, with glutamine as amido-N-donor]
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 516 aa
57.7 kDa 		No 0
GATB-003
ENSP00000420831
ENST00000512306
D6RDU9 [Direct mapping]
Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0016874 [ligase activity]
GO:0016884 [carbon-nitrogen ligase activity, with glutamine as amido-N-donor]
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 357 aa
39.5 kDa 		No 0
GATB-008
ENSP00000421105
ENST00000508611
D6RGY4 [Direct mapping]
Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0016874 [ligase activity]
GO:0016884 [carbon-nitrogen ligase activity, with glutamine as amido-N-donor]
Show all
 115 aa
12.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.