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YBX3

GENERAL INFORMATION

Gene name

 YBX3

Gene description

 Y box binding protein 3

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and nuclear expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA034838
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA034838

GENE INFORMATION

Gene name

 YBX3 (HGNC Symbol)

Synonyms

 CSDA, CSDA1, dbpA, ZONAB

Description

 Y box binding protein 3 (HGNC Symbol)

Entrez gene summary

Chromosome

 12

Cytoband

 p13.2

Chromosome location (bp)

 10699089 - 10723312

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000060138 (version 83.38)

Entrez gene

 8531

UniProt

 P16989 (UniProt - Evidence at protein level)

neXtProt

 NX_P16989

Antibodypedia

 YBX3 antibodies

PROTEIN BROWSER
YBX3-001
YBX3-003
YBX3-012

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
YBX3-001
ENSP00000228251
ENST00000228251
P16989 [Direct mapping]
Y-box-binding protein 3
A0A024RAQ1 [Target identity:100%; Query identity:100%]
Cold shock domain protein A, isoform CRA_a
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   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Transcription factors
   beta-Barrel DNA-binding domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0001701 [in utero embryonic development]
GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003697 [single-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003714 [transcription corepressor activity]
GO:0003730 [mRNA 3'-UTR binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005844 [polysome]
GO:0005923 [bicellular tight junction]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007283 [spermatogenesis]
GO:0008584 [male gonad development]
GO:0009409 [response to cold]
GO:0009566 [fertilization]
GO:0017048 [Rho GTPase binding]
GO:0030529 [ribonucleoprotein complex]
GO:0043066 [negative regulation of apoptotic process]
GO:0044822 [poly(A) RNA binding]
GO:0046622 [positive regulation of organ growth]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048642 [negative regulation of skeletal muscle tissue development]
GO:0060546 [negative regulation of necroptotic process]
GO:0070935 [3'-UTR-mediated mRNA stabilization]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0071474 [cellular hyperosmotic response]
GO:1902219 [negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress]
GO:2000767 [positive regulation of cytoplasmic translation]
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 372 aa
40.1 kDa 		No 0
YBX3-003
ENSP00000279550
ENST00000279550
P16989 [Direct mapping]
Y-box-binding protein 3
A0A024RAV4 [Target identity:100%; Query identity:100%]
Cold shock domain protein A, isoform CRA_b
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   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Transcription factors
   beta-Barrel DNA-binding domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003714 [transcription corepressor activity]
GO:0003730 [mRNA 3'-UTR binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005923 [bicellular tight junction]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0009409 [response to cold]
GO:0017048 [Rho GTPase binding]
GO:0044822 [poly(A) RNA binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0060546 [negative regulation of necroptotic process]
GO:0070935 [3'-UTR-mediated mRNA stabilization]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0071474 [cellular hyperosmotic response]
GO:1902219 [negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress]
GO:2000767 [positive regulation of cytoplasmic translation]
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 303 aa
31.9 kDa 		No 0
YBX3-012
ENSP00000485718
ENST00000544622
A0A0D9SEI8 [Direct mapping]
Y-box-binding protein 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0006355 [regulation of transcription, DNA-templated]
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 92 aa
10.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.