Cell atlas - CCAR1 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	CCAR1
Gene description	Cell division cycle and apoptosis regulator 1
Protein class	Cancer-related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to the Golgi apparatus.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (supported)
Additional location	In addition localized to the Golgi apparatus (supported)
Mouse	Localized to the Nucleoplasm in mouse cells.

DATA RELIABILITY
Reliability score	Supported based on 2 antibodies. HPA007856 , HPA048513
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ASSAYS

RNA expression

Human cells

Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to the Golgi apparatus.

Main location

Nucleoplasm (supported)

Additional location

Golgi apparatus (supported)


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Antibody	Cell line	Location
HPA048513	A-431	Nucleoplasm
HPA048513	U-2 OS	Nucleoplasm
HPA048513	U-251 MG	Nucleoplasm
HPA007856	A-431	Nucleoplasm
HPA007856	U-2 OS	Nucleoplasm
HPA007856	U-2 OS	Golgi apparatus
HPA007856	U-251 MG	Nucleoplasm
HPA007856	U-251 MG	Golgi apparatus

MOUSE CELLS

Main location

Nucleoplasm

Mouse gene

ENSMUSG00000020074 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA048513	NIH 3T3	Nucleoplasm

GENE INFORMATION
Gene name	CCAR1 (HGNC Symbol)
Synonyms	CARP-1, CARP1, FLJ10590
Description	Cell division cycle and apoptosis regulator 1 (HGNC Symbol)
Entrez gene summary
Chromosome	10
Cytoband	q21.3
Chromosome location (bp)	68721012 - 68792377
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000060339 (version 83.38)
Entrez gene	55749
UniProt	Q8IX12 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IX12
Antibodypedia	CCAR1 antibodies

PROTEIN BROWSER

CCAR1-001	CCAR1-003	CCAR1-009	CCAR1-012	CCAR1-013	CCAR1-014	CCAR1-017	CCAR1-018	CCAR1-021	CCAR1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CCAR1-001 ENSP00000265872 ENST00000265872	Q8IX12 [Direct mapping] Cell division cycle and apoptosis regulator protein 1 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000398 [mRNA splicing, via spliceosome] GO:0001047 [core promoter binding] GO:0003713 [transcription coactivator activity] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006915 [apoptotic process] GO:0007049 [cell cycle] GO:0008284 [positive regulation of cell proliferation] GO:0008380 [RNA splicing] GO:0010467 [gene expression] GO:0030335 [positive regulation of cell migration] GO:0030374 [ligand-dependent nuclear receptor transcription coactivator activity] GO:0044822 [poly(A) RNA binding] GO:0048471 [perinuclear region of cytoplasm] GO:1903507 [negative regulation of nucleic acid-templated transcription] Show all	1150 aa 132.8 kDa	No	0
CCAR1-003 ENSP00000442410 ENST00000538031	F5H7M9 [Direct mapping] Cell division cycle and apoptosis regulator protein 1 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0006355 [regulation of transcription, DNA-templated] Show all	171 aa 18.3 kDa	No	0
CCAR1-009 ENSP00000445254 ENST00000543719	Q8IX12 [Direct mapping] Cell division cycle and apoptosis regulator protein 1 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000398 [mRNA splicing, via spliceosome] GO:0001047 [core promoter binding] GO:0003713 [transcription coactivator activity] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006915 [apoptotic process] GO:0007049 [cell cycle] GO:0008284 [positive regulation of cell proliferation] GO:0008380 [RNA splicing] GO:0010467 [gene expression] GO:0030335 [positive regulation of cell migration] GO:0030374 [ligand-dependent nuclear receptor transcription coactivator activity] GO:0044822 [poly(A) RNA binding] GO:0048471 [perinuclear region of cytoplasm] GO:1903507 [negative regulation of nucleic acid-templated transcription] Show all	1135 aa 131 kDa	No	0
CCAR1-012 ENSP00000439252 ENST00000539539	A0A0C4DGG8 [Direct mapping] Cell division cycle and apoptosis regulator protein 1 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0006355 [regulation of transcription, DNA-templated] Show all	1043 aa 120.4 kDa	No	0
CCAR1-013 ENSP00000438610 ENST00000543225	F5H2E6 [Direct mapping] Cell division cycle and apoptosis regulator protein 1 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0006355 [regulation of transcription, DNA-templated] Show all	772 aa 88.2 kDa	No	0
CCAR1-014 ENSP00000439642 ENST00000536012	F5H1H2 [Direct mapping] Cell division cycle and apoptosis regulator protein 1 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0006355 [regulation of transcription, DNA-templated] Show all	646 aa 75.7 kDa	No	0
CCAR1-017 ENSP00000438881 ENST00000536391	F5H3I8 [Direct mapping] Cell division cycle and apoptosis regulator protein 1 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0006355 [regulation of transcription, DNA-templated] Show all	119 aa 12.4 kDa	No	0
CCAR1-018 ENSP00000443808 ENST00000494903	F5H808 [Direct mapping] Cell division cycle and apoptosis regulator protein 1 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0006355 [regulation of transcription, DNA-templated] Show all	95 aa 10.4 kDa	No	0
CCAR1-021 ENSP00000438939 ENST00000543706	H0YFJ7 [Direct mapping] Cell division cycle and apoptosis regulator protein 1 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0006355 [regulation of transcription, DNA-templated] Show all	290 aa 34.7 kDa	No	0
CCAR1-201 ENSP00000486408 ENST00000630771	F5H3E1 [Direct mapping] Cell division cycle and apoptosis regulator protein 1 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0006355 [regulation of transcription, DNA-templated] Show all	568 aa 64 kDa	No	0