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SNRNP40

GENERAL INFORMATION

Gene name

 SNRNP40

Gene description

 Small nuclear ribonucleoprotein 40kDa (U5)

Protein class

 Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA026527 , HPA027345
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and glioma (favourable).
Liver cancer p<0.001
Glioma p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA026527
HPA027345

GENE INFORMATION

Gene name

 SNRNP40 (HGNC Symbol)

Synonyms

 HPRP8BP, PRP8BP, PRPF8BP, SPF38, WDR57

Description

 Small nuclear ribonucleoprotein 40kDa (U5) (HGNC Symbol)

Entrez gene summary

 This gene encodes a component of the U5 small nuclear ribonucleoprotein (snRNP) particle. The U5 snRNP is part of the spliceosome, a multiprotein complex that catalyzes the removal of introns from pre-messenger RNAs. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p35.2

Chromosome location (bp)

 31259568 - 31296782

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000060688 (version 83.38)

Entrez gene

 9410

UniProt

 Q96DI7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96DI7

Antibodypedia

 SNRNP40 antibodies

PROTEIN BROWSER
SNRNP40-001
SNRNP40-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SNRNP40-001
ENSP00000263694
ENST00000263694
Q96DI7 [Direct mapping]
U5 small nuclear ribonucleoprotein 40 kDa protein
A0MNP2 [Target identity:100%; Query identity:100%]
CDW11/WDR57; WD repeat domain 57 (U5 snRNP specific), isoform CRA_a; cDNA FLJ90035 fis, clone HEMBA1001878, highly similar to WD repeat protein 57
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000375 [RNA splicing, via transesterification reactions]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005682 [U5 snRNP]
GO:0005732 [small nucleolar ribonucleoprotein complex]
GO:0005737 [cytoplasm]
GO:0006396 [RNA processing]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0044822 [poly(A) RNA binding]
GO:0071011 [precatalytic spliceosome]
GO:0071013 [catalytic step 2 spliceosome]
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 357 aa
39.3 kDa 		No 0
SNRNP40-002
ENSP00000362825
ENST00000373720
Q9NSS8 [Direct mapping]
Putative uncharacterized protein DKFZp434D199; U5 small nuclear ribonucleoprotein 40 kDa protein; WD repeat domain 57 (U5 snRNP specific), isoform CRA_b
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0016021 [integral component of membrane]
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 127 aa
14.3 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.