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ACAA1

GENERAL INFORMATION

Gene name

 ACAA1

Gene description

 Acetyl-CoA acyltransferase 1

Protein class

 Enzymes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most glandular cells. Distinct expression in hepatocytes, heart muscle and neuronal cells in CNS.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA006764 , HPA007244
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable), head and neck cancer (favourable), breast cancer (favourable) and endometrial cancer (favourable).
Renal cancer p<0.001
Head and neck cancer p<0.001
Breast cancer p<0.001
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA006764
HPA007244

GENE INFORMATION

Gene name

 ACAA1

Synonyms

Description

 Acetyl-CoA acyltransferase 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes an enzyme operative in the beta-oxidation system of the peroxisomes. Deficiency of this enzyme leads to pseudo-Zellweger syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

Chromosome

 3

Cytoband

 p22.2

Chromosome location (bp)

 38103129 - 38137242

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000060971 (version 83.38)

Entrez gene

 30

UniProt

 P09110 (UniProt - Evidence at protein level)

neXtProt

 NX_P09110

Antibodypedia

 ACAA1 antibodies

PROTEIN BROWSER
ACAA1-001
ACAA1-002
ACAA1-007
ACAA1-014
ACAA1-019
ACAA1-201
ACAA1-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ACAA1-001
ENSP00000333664
ENST00000333167
P09110 [Direct mapping]
3-ketoacyl-CoA thiolase, peroxisomal
A0A024R2M6 [Target identity:100%; Query identity:100%]
Acetyl-Coenzyme A acyltransferase 1 (Peroxisomal 3-oxoacyl-Coenzyme A thiolase), isoform CRA_a
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Enzymes
   ENZYME proteins
   Transferases
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000038 [very long-chain fatty acid metabolic process]
GO:0003824 [catalytic activity]
GO:0003988 [acetyl-CoA C-acyltransferase activity]
GO:0005515 [protein binding]
GO:0005777 [peroxisome]
GO:0005782 [peroxisomal matrix]
GO:0006635 [fatty acid beta-oxidation]
GO:0008152 [metabolic process]
GO:0008206 [bile acid metabolic process]
GO:0016020 [membrane]
GO:0016401 [palmitoyl-CoA oxidase activity]
GO:0016747 [transferase activity, transferring acyl groups other than amino-acyl groups]
GO:0033540 [fatty acid beta-oxidation using acyl-CoA oxidase]
GO:0033559 [unsaturated fatty acid metabolic process]
GO:0036109 [alpha-linolenic acid metabolic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
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 424 aa
44.3 kDa 		No 0
ACAA1-002
ENSP00000301810
ENST00000301810
P09110 [Direct mapping]
3-ketoacyl-CoA thiolase, peroxisomal
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Enzymes
   ENZYME proteins
   Transferases
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000038 [very long-chain fatty acid metabolic process]
GO:0003824 [catalytic activity]
GO:0003988 [acetyl-CoA C-acyltransferase activity]
GO:0005515 [protein binding]
GO:0005777 [peroxisome]
GO:0005782 [peroxisomal matrix]
GO:0006635 [fatty acid beta-oxidation]
GO:0008152 [metabolic process]
GO:0008206 [bile acid metabolic process]
GO:0016020 [membrane]
GO:0016401 [palmitoyl-CoA oxidase activity]
GO:0016747 [transferase activity, transferring acyl groups other than amino-acyl groups]
GO:0033540 [fatty acid beta-oxidation using acyl-CoA oxidase]
GO:0033559 [unsaturated fatty acid metabolic process]
GO:0036109 [alpha-linolenic acid metabolic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
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 331 aa
34.7 kDa 		No 0
ACAA1-007
ENSP00000395183
ENST00000450296
C9JDE9 [Direct mapping]
3-ketoacyl-CoA thiolase, peroxisomal
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   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0008152 [metabolic process]
GO:0016747 [transferase activity, transferring acyl groups other than amino-acyl groups]
GO:0043231 [intracellular membrane-bounded organelle]
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 383 aa
40.3 kDa 		No 0
ACAA1-014
ENSP00000398172
ENST00000421218
H7C131 [Direct mapping]
3-ketoacyl-CoA thiolase, peroxisomal
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0008152 [metabolic process]
GO:0016747 [transferase activity, transferring acyl groups other than amino-acyl groups]
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 290 aa
30.2 kDa 		No 0
ACAA1-019
ENSP00000391078
ENST00000452171
H0Y4D4 [Direct mapping]
3-ketoacyl-CoA thiolase, peroxisomal
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   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0008152 [metabolic process]
GO:0016747 [transferase activity, transferring acyl groups other than amino-acyl groups]
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 237 aa
24.9 kDa 		No 0
ACAA1-201
ENSP00000486456
ENST00000625927
F2Z2Q6 [Direct mapping]
3-ketoacyl-CoA thiolase, peroxisomal
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0008152 [metabolic process]
GO:0016747 [transferase activity, transferring acyl groups other than amino-acyl groups]
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 113 aa
12.2 kDa 		No 0
ACAA1-202
ENSP00000486920
ENST00000627515
F2Z3P7 [Direct mapping]
3-ketoacyl-CoA thiolase, peroxisomal
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   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0008152 [metabolic process]
GO:0016747 [transferase activity, transferring acyl groups other than amino-acyl groups]
Show all
 121 aa
13 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.