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LZTS1

GENERAL INFORMATION

Gene name

 LZTS1

Gene description

 Leucine zipper, putative tumor suppressor 1

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (SK-MEL-30, WM-115)
HPA (normal tissue):Tissue enriched (parathyroid gland)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA006294 , HPA022046
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and endometrial cancer (unfavourable).
Renal cancer p<0.001
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA006294
HPA022046

GENE INFORMATION

Gene name

 LZTS1 (HGNC Symbol)

Synonyms

 FEZ1

Description

 Leucine zipper, putative tumor suppressor 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a tumor suppressor protein that is ubiquitously expressed in normal tissues. In uveal melanomas, expression of this protein is silenced in rapidly metastasizing and metastatic tumor cells but has normal expression in slowly metastasizing or nonmetastasizing tumor cells. This protein may have a role in cell-cycle control by interacting with the Cdk1/cyclinB1 complex. This gene is located on chromosomal region 8p22. Loss of heterozygosity (LOH) in the 8p arm is a common characteristic of many types of cancer. [provided by RefSeq, Nov 2009]

Chromosome

 8

Cytoband

 p21.3

Chromosome location (bp)

 20246165 - 20303963

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000061337 (version 83.38)

Entrez gene

 11178

UniProt

 Q9Y250 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y250

Antibodypedia

 LZTS1 antibodies

PROTEIN BROWSER
LZTS1-001
LZTS1-002
LZTS1-201
LZTS1-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LZTS1-001
ENSP00000370981
ENST00000381569
Q9Y250 [Direct mapping]
Leucine zipper putative tumor suppressor 1
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Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007049 [cell cycle]
GO:0014069 [postsynaptic density]
GO:0016242 [negative regulation of macroautophagy]
GO:0016324 [apical plasma membrane]
GO:0030054 [cell junction]
GO:0043005 [neuron projection]
GO:0043197 [dendritic spine]
GO:0043198 [dendritic shaft]
GO:0044297 [cell body]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0048814 [regulation of dendrite morphogenesis]
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 596 aa
66.6 kDa 		No 0
LZTS1-002
ENSP00000429263
ENST00000522290
Q9Y250 [Direct mapping]
Leucine zipper putative tumor suppressor 1
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007049 [cell cycle]
GO:0014069 [postsynaptic density]
GO:0016242 [negative regulation of macroautophagy]
GO:0030054 [cell junction]
GO:0043197 [dendritic spine]
Show all
 537 aa
59.8 kDa 		No 0
LZTS1-201
ENSP00000265801
ENST00000265801
Q9Y250 [Direct mapping]
Leucine zipper putative tumor suppressor 1
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007049 [cell cycle]
GO:0014069 [postsynaptic density]
GO:0016242 [negative regulation of macroautophagy]
GO:0030054 [cell junction]
GO:0043197 [dendritic spine]
Show all
 596 aa
66.6 kDa 		No 0
LZTS1-202
ENSP00000479534
ENST00000616228
Q9Y250 [Direct mapping]
Leucine zipper putative tumor suppressor 1
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007049 [cell cycle]
GO:0014069 [postsynaptic density]
GO:0016242 [negative regulation of macroautophagy]
GO:0030054 [cell junction]
GO:0043197 [dendritic spine]
Show all
 76 aa
8.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.