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GUCY1B3

GENERAL INFORMATION

Gene name

 GUCY1B3

Gene description

 Guanylate cyclase 1, soluble, beta 3

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (HEL, MOLT-4, RPTEC TERT1)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA020870 , CAB010890
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and testis cancer (unfavourable).
Renal cancer p<0.001
Testis cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Renal cancer

STAINING SUMMARY
HPA020870
CAB010890

GENE INFORMATION

Gene name

 GUCY1B3 (HGNC Symbol)

Synonyms

 GC-S-beta-1, GC-SB3, GUC1B3

Description

 Guanylate cyclase 1, soluble, beta 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes the beta subunit of the soluble guanylate cyclase (sGC), which catalyzes the conversion of GTP (guanosine triphosphate) to cGMP (cyclic guanosine monophosphate). The encoded protein contains an HNOX domain, which serves as a receptor for ligands such as nitric oxide, oxygen and nitrovasodilator drugs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

Chromosome

 4

Cytoband

 q32.1

Chromosome location (bp)

 155758992 - 155807591

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000061918 (version 83.38)

Entrez gene

 2983

UniProt

 Q02153 (UniProt - Evidence at protein level)

neXtProt

 NX_Q02153

Antibodypedia

 GUCY1B3 antibodies

PROTEIN BROWSER
GUCY1B3-001
GUCY1B3-003
GUCY1B3-004
GUCY1B3-005
GUCY1B3-007
GUCY1B3-008
GUCY1B3-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GUCY1B3-001
ENSP00000427226
ENST00000505154
B7Z685 [Direct mapping]
Guanylate cyclase 1, soluble, beta 3, isoform CRA_c; Guanylate cyclase soluble subunit beta-1; cDNA FLJ50853, highly similar to Guanylate cyclase soluble subunit beta-1 (EC 4.6.1.2)
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0000166 [nucleotide binding]
GO:0004383 [guanylate cyclase activity]
GO:0005622 [intracellular]
GO:0006182 [cGMP biosynthetic process]
GO:0009190 [cyclic nucleotide biosynthetic process]
GO:0016849 [phosphorus-oxygen lyase activity]
GO:0020037 [heme binding]
GO:0035556 [intracellular signal transduction]
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 551 aa
62.8 kDa 		No 0
GUCY1B3-003
ENSP00000426786
ENST00000502959
E9PCN2 [Direct mapping]
Guanylate cyclase soluble subunit beta-1
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   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0004383 [guanylate cyclase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006182 [cGMP biosynthetic process]
GO:0007263 [nitric oxide mediated signal transduction]
GO:0008074 [guanylate cyclase complex, soluble]
GO:0009190 [cyclic nucleotide biosynthetic process]
GO:0016849 [phosphorus-oxygen lyase activity]
GO:0020037 [heme binding]
GO:0035556 [intracellular signal transduction]
GO:0043167 [ion binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043234 [protein complex]
GO:0046982 [protein heterodimerization activity]
GO:0051879 [Hsp90 protein binding]
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 641 aa
73.1 kDa 		No 0
GUCY1B3-004
ENSP00000426319
ENST00000505764
Q02153 [Direct mapping]
Guanylate cyclase soluble subunit beta-1
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Enzymes
   ENZYME proteins
   Lyases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004383 [guanylate cyclase activity]
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006182 [cGMP biosynthetic process]
GO:0007263 [nitric oxide mediated signal transduction]
GO:0007596 [blood coagulation]
GO:0008015 [blood circulation]
GO:0008074 [guanylate cyclase complex, soluble]
GO:0009190 [cyclic nucleotide biosynthetic process]
GO:0016849 [phosphorus-oxygen lyase activity]
GO:0020037 [heme binding]
GO:0035556 [intracellular signal transduction]
GO:0038060 [nitric oxide-cGMP-mediated signaling pathway]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0046872 [metal ion binding]
GO:0071732 [cellular response to nitric oxide]
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 599 aa
68.2 kDa 		No 0
GUCY1B3-005
ENSP00000422313
ENST00000507146
D6RC99 [Direct mapping]
Guanylate cyclase soluble subunit beta-1
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   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0004383 [guanylate cyclase activity]
GO:0005622 [intracellular]
GO:0006182 [cGMP biosynthetic process]
GO:0009190 [cyclic nucleotide biosynthetic process]
GO:0016849 [phosphorus-oxygen lyase activity]
GO:0020037 [heme binding]
GO:0035556 [intracellular signal transduction]
Show all
 594 aa
67.5 kDa 		No 0
GUCY1B3-007
ENSP00000264424
ENST00000264424
Q02153 [Direct mapping]
Guanylate cyclase soluble subunit beta-1
Show all
Enzymes
   ENZYME proteins
   Lyases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004383 [guanylate cyclase activity]
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006182 [cGMP biosynthetic process]
GO:0007263 [nitric oxide mediated signal transduction]
GO:0007596 [blood coagulation]
GO:0008015 [blood circulation]
GO:0008074 [guanylate cyclase complex, soluble]
GO:0009190 [cyclic nucleotide biosynthetic process]
GO:0016849 [phosphorus-oxygen lyase activity]
GO:0020037 [heme binding]
GO:0035556 [intracellular signal transduction]
GO:0038060 [nitric oxide-cGMP-mediated signaling pathway]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0046872 [metal ion binding]
GO:0071732 [cellular response to nitric oxide]
Show all
 619 aa
70.5 kDa 		No 0
GUCY1B3-008
ENSP00000425065
ENST00000513437
B7Z685 [Direct mapping]
Guanylate cyclase 1, soluble, beta 3, isoform CRA_c; Guanylate cyclase soluble subunit beta-1; cDNA FLJ50853, highly similar to Guanylate cyclase soluble subunit beta-1 (EC 4.6.1.2)
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0004383 [guanylate cyclase activity]
GO:0005622 [intracellular]
GO:0006182 [cGMP biosynthetic process]
GO:0009190 [cyclic nucleotide biosynthetic process]
GO:0016849 [phosphorus-oxygen lyase activity]
GO:0020037 [heme binding]
GO:0035556 [intracellular signal transduction]
Show all
 551 aa
62.8 kDa 		No 0
GUCY1B3-010
ENSP00000420842
ENST00000503520
Q02153 [Direct mapping]
Guanylate cyclase soluble subunit beta-1
Show all
Enzymes
   ENZYME proteins
   Lyases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004383 [guanylate cyclase activity]
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006182 [cGMP biosynthetic process]
GO:0007263 [nitric oxide mediated signal transduction]
GO:0007596 [blood coagulation]
GO:0008015 [blood circulation]
GO:0008074 [guanylate cyclase complex, soluble]
GO:0009190 [cyclic nucleotide biosynthetic process]
GO:0016849 [phosphorus-oxygen lyase activity]
GO:0020037 [heme binding]
GO:0035556 [intracellular signal transduction]
GO:0038060 [nitric oxide-cGMP-mediated signaling pathway]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0046872 [metal ion binding]
GO:0071732 [cellular response to nitric oxide]
Show all
 586 aa
66.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.