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TNK2

GENERAL INFORMATION

Gene name

 TNK2

Gene description

 Tyrosine kinase, non-receptor, 2

Protein class

 Cancer-related genes
Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 1 antibody.
HPA041954
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PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (favourable), renal cancer (unfavourable) and endometrial cancer (unfavourable).
Urothelial cancer p<0.001
Renal cancer p<0.001
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA041954

GENE INFORMATION

Gene name

 TNK2 (HGNC Symbol)

Synonyms

 ACK, ACK1, p21cdc42Hs

Description

 Tyrosine kinase, non-receptor, 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008]

Chromosome

 3

Cytoband

 q29

Chromosome location (bp)

 195863364 - 195911945

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000061938 (version 83.38)

Entrez gene

 10188

UniProt

 Q07912 (UniProt - Evidence at protein level)

neXtProt

 NX_Q07912

Antibodypedia

 TNK2 antibodies

PROTEIN BROWSER
TNK2-002
TNK2-005
TNK2-007
TNK2-010
TNK2-012
TNK2-014
TNK2-016
TNK2-019
TNK2-020

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TNK2-002
ENSP00000329425
ENST00000333602
Q07912 [Direct mapping]
Activated CDC42 kinase 1
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005095 [GTPase inhibitor activity]
GO:0005154 [epidermal growth factor receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005886 [plasma membrane]
GO:0005905 [coated pit]
GO:0005912 [adherens junction]
GO:0006468 [protein phosphorylation]
GO:0006897 [endocytosis]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0016020 [membrane]
GO:0016310 [phosphorylation]
GO:0016477 [cell migration]
GO:0030136 [clathrin-coated vesicle]
GO:0030154 [cell differentiation]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0034260 [negative regulation of GTPase activity]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042127 [regulation of cell proliferation]
GO:0042802 [identical protein binding]
GO:0045087 [innate immune response]
GO:0046872 [metal ion binding]
GO:0050699 [WW domain binding]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0051427 [hormone receptor binding]
GO:0070436 [Grb2-EGFR complex]
GO:2000369 [regulation of clathrin-mediated endocytosis]
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 1038 aa
114.6 kDa 		No 0
TNK2-005
ENSP00000371341
ENST00000381916
Q07912 [Direct mapping]
Activated CDC42 kinase 1
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005095 [GTPase inhibitor activity]
GO:0005154 [epidermal growth factor receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005886 [plasma membrane]
GO:0005905 [coated pit]
GO:0005912 [adherens junction]
GO:0006468 [protein phosphorylation]
GO:0006897 [endocytosis]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0016020 [membrane]
GO:0016310 [phosphorylation]
GO:0016477 [cell migration]
GO:0030136 [clathrin-coated vesicle]
GO:0030154 [cell differentiation]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0030426 [growth cone]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0034260 [negative regulation of GTPase activity]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042127 [regulation of cell proliferation]
GO:0042802 [identical protein binding]
GO:0043025 [neuronal cell body]
GO:0045087 [innate immune response]
GO:0046872 [metal ion binding]
GO:0050699 [WW domain binding]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0051427 [hormone receptor binding]
GO:0070436 [Grb2-EGFR complex]
GO:2000369 [regulation of clathrin-mediated endocytosis]
Show all
 1086 aa
119.3 kDa 		No 0
TNK2-007
ENSP00000392546
ENST00000428187
C9J1X3 [Direct mapping]
Activated CDC42 kinase 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0016477 [cell migration]
GO:0030154 [cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042127 [regulation of cell proliferation]
GO:0045087 [innate immune response]
GO:0051427 [hormone receptor binding]
Show all
 1040 aa
115 kDa 		No 0
TNK2-010
ENSP00000398614
ENST00000416152
H0Y5H7 [Direct mapping]
Activated CDC42 kinase 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0016477 [cell migration]
GO:0030154 [cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042127 [regulation of cell proliferation]
GO:0045087 [innate immune response]
GO:0051427 [hormone receptor binding]
Show all
 607 aa
65.3 kDa 		No 0
TNK2-012
ENSP00000390088
ENST00000427576
C9JIR5 [Direct mapping]
Activated CDC42 kinase 1
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   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0016477 [cell migration]
GO:0030154 [cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042127 [regulation of cell proliferation]
GO:0045087 [innate immune response]
GO:0051427 [hormone receptor binding]
Show all
 143 aa
16.4 kDa 		No 0
TNK2-014
ENSP00000395154
ENST00000433111
C9JDG3 [Direct mapping]
Activated CDC42 kinase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0016477 [cell migration]
GO:0030154 [cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042127 [regulation of cell proliferation]
GO:0045087 [innate immune response]
GO:0051427 [hormone receptor binding]
Show all
 97 aa
11.6 kDa 		No 0
TNK2-016
ENSP00000392253
ENST00000438207
H7BZZ3 [Direct mapping]
Activated CDC42 kinase 1
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0016477 [cell migration]
GO:0030154 [cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042127 [regulation of cell proliferation]
GO:0045087 [innate immune response]
GO:0051427 [hormone receptor binding]
Show all
 290 aa
33.6 kDa 		No 0
TNK2-019
ENSP00000415126
ENST00000411741
H7C412 [Direct mapping]
Activated CDC42 kinase 1
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0016477 [cell migration]
GO:0030154 [cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042127 [regulation of cell proliferation]
GO:0045087 [innate immune response]
GO:0051427 [hormone receptor binding]
Show all
 200 aa
21.6 kDa 		No 0
TNK2-020
ENSP00000390435
ENST00000424563
H7BZM8 [Direct mapping]
Activated CDC42 kinase 1
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0016477 [cell migration]
GO:0030154 [cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042127 [regulation of cell proliferation]
GO:0045087 [innate immune response]
GO:0051427 [hormone receptor binding]
Show all
 242 aa
26.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.