Expression of MON2 in cancer - Summary - The Human Protein Atlas

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MON2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MON2
Gene description	MON2 homolog, regulator of endosome-to-Golgi trafficking
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA038697 , HPA057607
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PROGNOSTIC SUMMARY
Prognostic marker in head and neck cancer (favourable).
Head and neck cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA038697	HPA057607

GENE INFORMATION
Gene name	MON2 (HGNC Symbol)
Synonyms	KIAA1040
Description	MON2 homolog, regulator of endosome-to-Golgi trafficking (HGNC Symbol)
Entrez gene summary
Chromosome	12
Cytoband	q14.1
Chromosome location (bp)	62466817 - 62600479
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000061987 (version 83.38)
Entrez gene	23041
UniProt	Q7Z3U7 (UniProt - Evidence at protein level)
neXtProt	NX_Q7Z3U7
Antibodypedia	MON2 antibodies

PROTEIN BROWSER

MON2-001	MON2-002	MON2-005	MON2-006	MON2-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MON2-001 ENSP00000377250 ENST00000393630	Q7Z3U7 [Direct mapping] Protein MON2 homolog Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005086 [ARF guanyl-nucleotide exchange factor activity] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005802 [trans-Golgi network] GO:0006895 [Golgi to endosome transport] GO:0015031 [protein transport] GO:0016192 [vesicle-mediated transport] GO:0043547 [positive regulation of GTPase activity] GO:0070062 [extracellular exosome] Show all	1717 aa 190.4 kDa	No	0
MON2-002 ENSP00000447407 ENST00000546600	Q7Z3U7 [Direct mapping] Protein MON2 homolog Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005086 [ARF guanyl-nucleotide exchange factor activity] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005802 [trans-Golgi network] GO:0006895 [Golgi to endosome transport] GO:0015031 [protein transport] GO:0016192 [vesicle-mediated transport] GO:0043547 [positive regulation of GTPase activity] GO:0070062 [extracellular exosome] Show all	1675 aa 185.9 kDa	No	0
MON2-005 ENSP00000449215 ENST00000552738	Q7Z3U7 [Direct mapping] Protein MON2 homolog Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005086 [ARF guanyl-nucleotide exchange factor activity] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005802 [trans-Golgi network] GO:0006895 [Golgi to endosome transport] GO:0015031 [protein transport] GO:0016192 [vesicle-mediated transport] GO:0043547 [positive regulation of GTPase activity] GO:0070062 [extracellular exosome] Show all	1688 aa 187.3 kDa	No	0
MON2-006 ENSP00000446635 ENST00000552115	F8VZV1 [Direct mapping] Protein MON2 homolog Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005086 [ARF guanyl-nucleotide exchange factor activity] GO:0005488 [binding] GO:0005802 [trans-Golgi network] GO:0016192 [vesicle-mediated transport] GO:0043547 [positive regulation of GTPase activity] Show all	1072 aa 118 kDa	No	0
MON2-008 ENSP00000377249 ENST00000393629	Q7Z3U7 [Direct mapping] Protein MON2 homolog Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005086 [ARF guanyl-nucleotide exchange factor activity] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005802 [trans-Golgi network] GO:0006895 [Golgi to endosome transport] GO:0015031 [protein transport] GO:0016192 [vesicle-mediated transport] GO:0043547 [positive regulation of GTPase activity] GO:0070062 [extracellular exosome] Show all	1711 aa 189.7 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.