Expression of SEZ6 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

SEZ6

premium

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SEZ6
Gene description	Seizure related 6 homolog (mouse)
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	8
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (glioma)
HPA (cell line):	Cell line enriched (SCLC-21H)
HPA (normal tissue):	Tissue enriched (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Expression mainly in CNS.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA011777
	SHOW MORE

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (glioma)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA011777

GENE INFORMATION
Gene name	SEZ6
Synonyms
Description	Seizure related 6 homolog (mouse) (HGNC Symbol)
Entrez gene summary
Chromosome	17
Cytoband	q11.2
Chromosome location (bp)	28954901 - 29006440
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000063015 (version 83.38)
Entrez gene	124925
UniProt	Q53EL9 (UniProt - Evidence at protein level)
neXtProt	NX_Q53EL9
Antibodypedia	SEZ6 antibodies

PROTEIN BROWSER

SEZ6-001	SEZ6-002	SEZ6-003	SEZ6-012	SEZ6-013	SEZ6-017	SEZ6-018	SEZ6-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SEZ6-001 ENSP00000353440 ENST00000360295	Q53EL9 [Direct mapping] Seizure protein 6 homolog Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] Show all	993 aa 107.5 kDa	Yes	1
SEZ6-002 ENSP00000312942 ENST00000317338	Q53EL9 [Direct mapping] Seizure protein 6 homolog Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005615 [extracellular space] GO:0005783 [endoplasmic reticulum] GO:0005886 [plasma membrane] GO:0008344 [adult locomotory behavior] GO:0016021 [integral component of membrane] GO:0021680 [cerebellar Purkinje cell layer development] GO:0043025 [neuronal cell body] GO:0043197 [dendritic spine] GO:0043198 [dendritic shaft] GO:0048471 [perinuclear region of cytoplasm] GO:0050773 [regulation of dendrite development] GO:0060074 [synapse maturation] GO:0060079 [excitatory postsynaptic potential] GO:0090036 [regulation of protein kinase C signaling] GO:0097440 [apical dendrite] GO:1900006 [positive regulation of dendrite development] GO:2000171 [negative regulation of dendrite development] Show all	994 aa 107.4 kDa	Yes	1
SEZ6-003 ENSP00000437650 ENST00000540632	H0YF95 [Direct mapping] Seizure protein 6 homolog Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	919 aa 99.7 kDa	No	1
SEZ6-012 ENSP00000403784 ENST00000442608	A0A0A0MSU7 [Direct mapping] Seizure protein 6 homolog Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	980 aa 106 kDa	Yes	1
SEZ6-013 ENSP00000443589 ENST00000539265	H0YGK0 [Direct mapping] Seizure protein 6 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		131 aa 13.9 kDa	No	0
SEZ6-017 ENSP00000466107 ENST00000585644	K7ELJ4 [Direct mapping] Seizure protein 6 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		57 aa 5.9 kDa	No	0
SEZ6-018 ENSP00000440216 ENST00000535262	H0YFT6 [Direct mapping] Seizure protein 6 homolog Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	101 aa 10.9 kDa	No	2
SEZ6-201 ENSP00000337407 ENST00000335960	C9JFF1 [Direct mapping] Seizure protein 6 homolog Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	994 aa 107.4 kDa	Yes	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.