Expression of SLC6A16 in cancer - Summary - The Human Protein Atlas

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SLC6A16

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	SLC6A16
Gene description	Solute carrier family 6, member 16
Protein class	Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (AF22)
HPA (normal tissue):	Tissue enriched (testis)

Protein evidence

Evidence at transcript level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	SLC6A16 (HGNC Symbol)
Synonyms	NTT5
Description	Solute carrier family 6, member 16 (HGNC Symbol)
Entrez gene summary	SLC6A16 shows structural characteristics of an Na(+)- and Cl(-)-dependent neurotransmitter transporter, including 12 transmembrane (TM) domains, intracellular N and C termini, and large extracellular loops containing multiple N-glycosylation sites.[supplied by OMIM, Mar 2008]
Chromosome	19
Cytoband	q13.33
Chromosome location (bp)	49289638 - 49325225
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000063127 (version 83.38)
Entrez gene	28968
UniProt	Q9GZN6 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9GZN6
Antibodypedia	SLC6A16 antibodies

PROTEIN BROWSER

SLC6A16-001	SLC6A16-002	SLC6A16-004	SLC6A16-006	SLC6A16-007	SLC6A16-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC6A16-001 ENSP00000338627 ENST00000335875	Q9GZN6 [Direct mapping] Orphan sodium- and chloride-dependent neurotransmitter transporter NTT5 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0003333 [amino acid transmembrane transport] GO:0005326 [neurotransmitter transporter activity] GO:0005328 [neurotransmitter:sodium symporter activity] GO:0005622 [intracellular] GO:0005887 [integral component of plasma membrane] GO:0006836 [neurotransmitter transport] GO:0015171 [amino acid transmembrane transporter activity] GO:0016021 [integral component of membrane] Show all	736 aa 82.2 kDa	No	>9
SLC6A16-002 ENSP00000404022 ENST00000454748	Q9GZN6 [Direct mapping] Orphan sodium- and chloride-dependent neurotransmitter transporter NTT5 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0003333 [amino acid transmembrane transport] GO:0005326 [neurotransmitter transporter activity] GO:0005328 [neurotransmitter:sodium symporter activity] GO:0005622 [intracellular] GO:0005887 [integral component of plasma membrane] GO:0006836 [neurotransmitter transport] GO:0015171 [amino acid transmembrane transporter activity] GO:0016021 [integral component of membrane] Show all	659 aa 73.5 kDa	No	>9
SLC6A16-004 ENSP00000469885 ENST00000598828	M0QYK3 [Direct mapping] Transporter Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0005328 [neurotransmitter:sodium symporter activity] GO:0006836 [neurotransmitter transport] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	163 aa 18.6 kDa	No	3
SLC6A16-006 ENSP00000472752 ENST00000597969	M0R2R5 [Direct mapping] Transporter Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0005328 [neurotransmitter:sodium symporter activity] GO:0006836 [neurotransmitter transport] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	147 aa 16.7 kDa	No	2
SLC6A16-007 ENSP00000472191 ENST00000594917	M0R1Y6 [Direct mapping] Transporter Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0005328 [neurotransmitter:sodium symporter activity] GO:0006836 [neurotransmitter transport] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	136 aa 15.3 kDa	No	2
SLC6A16-008 ENSP00000470623 ENST00000594180	M0QZL4 [Direct mapping] Orphan sodium- and chloride-dependent neurotransmitter transporter NTT5 Show all	SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins SignalP predicted secreted proteins Predicted intracellular proteins Show all		33 aa 3.8 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
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