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U2AF2

GENERAL INFORMATION

Gene name

 U2AF2

Gene description

 U2 small nuclear RNA auxiliary factor 2

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA043562 , CAB010910
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA043562
CAB010910

GENE INFORMATION

Gene name

 U2AF2 (HGNC Symbol)

Synonyms

 U2AF65

Description

 U2 small nuclear RNA auxiliary factor 2 (HGNC Symbol)

Entrez gene summary

 U2 auxiliary factor (U2AF), comprised of a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the U2AF large subunit which contains a sequence-specific RNA-binding region with 3 RNA recognition motifs and an Arg/Ser-rich domain necessary for splicing. The large subunit binds to the polypyrimidine tract of introns early during spliceosome assembly. Multiple transcript variants have been detected for this gene, but the full-length natures of only two have been determined to date. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 q13.42

Chromosome location (bp)

 55654146 - 55674715

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000063244 (version 83.38)

Entrez gene

 11338

UniProt

 P26368 (UniProt - Evidence at protein level)

neXtProt

 NX_P26368

Antibodypedia

 U2AF2 antibodies

PROTEIN BROWSER
U2AF2-001
U2AF2-002
U2AF2-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
U2AF2-001
ENSP00000388475
ENST00000450554
P26368 [Direct mapping]
Splicing factor U2AF 65 kDa subunit
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000166 [nucleotide binding]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0000974 [Prp19 complex]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005681 [spliceosomal complex]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006369 [termination of RNA polymerase II transcription]
GO:0006397 [mRNA processing]
GO:0006406 [mRNA export from nucleus]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0016607 [nuclear speck]
GO:0019899 [enzyme binding]
GO:0030628 [pre-mRNA 3'-splice site binding]
GO:0031124 [mRNA 3'-end processing]
GO:0033120 [positive regulation of RNA splicing]
GO:0044822 [poly(A) RNA binding]
GO:0048025 [negative regulation of mRNA splicing, via spliceosome]
GO:0071004 [U2-type prespliceosome]
GO:0089701 [U2AF]
GO:1903146 [regulation of mitophagy]
GO:1903955 [positive regulation of protein targeting to mitochondrion]
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 471 aa
53.1 kDa 		No 0
U2AF2-002
ENSP00000307863
ENST00000308924
P26368 [Direct mapping]
Splicing factor U2AF 65 kDa subunit
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0000974 [Prp19 complex]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005681 [spliceosomal complex]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006369 [termination of RNA polymerase II transcription]
GO:0006397 [mRNA processing]
GO:0006406 [mRNA export from nucleus]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0016607 [nuclear speck]
GO:0019899 [enzyme binding]
GO:0030628 [pre-mRNA 3'-splice site binding]
GO:0031124 [mRNA 3'-end processing]
GO:0033120 [positive regulation of RNA splicing]
GO:0044822 [poly(A) RNA binding]
GO:0048025 [negative regulation of mRNA splicing, via spliceosome]
GO:0070742 [C2H2 zinc finger domain binding]
GO:0071004 [U2-type prespliceosome]
GO:0089701 [U2AF]
GO:1903146 [regulation of mitophagy]
GO:1903955 [positive regulation of protein targeting to mitochondrion]
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 475 aa
53.5 kDa 		No 0
U2AF2-008
ENSP00000466935
ENST00000590551
K7ENG2 [Direct mapping]
Splicing factor U2AF 65 kDa subunit
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   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0005634 [nucleus]
GO:0006397 [mRNA processing]
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 307 aa
33.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.