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HAGH

GENERAL INFORMATION

Gene name

 HAGH

Gene description

 Hydroxyacylglutathione hydrolase

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA043041 , HPA061143
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable), liver cancer (favourable), cervical cancer (favourable) and urothelial cancer (favourable).
Renal cancer p<0.001
Liver cancer p<0.001
Cervical cancer p<0.001
Urothelial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA043041
HPA061143

GENE INFORMATION

Gene name

 HAGH (HGNC Symbol)

Synonyms

 GLO2, GLXII, HAGH1

Description

 Hydroxyacylglutathione hydrolase (HGNC Symbol)

Entrez gene summary

 The enzyme encoded by this gene is classified as a thiolesterase and is responsible for the hydrolysis of S-lactoyl-glutathione to reduced glutathione and D-lactate. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]

Chromosome

 16

Cytoband

 p13.3

Chromosome location (bp)

 1795620 - 1827194

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000063854 (version 83.38)

Entrez gene

 3029

UniProt

 Q16775 (UniProt - Evidence at protein level)

neXtProt

 NX_Q16775

Antibodypedia

 HAGH antibodies

PROTEIN BROWSER
HAGH-001
HAGH-002
HAGH-003
HAGH-004
HAGH-010
HAGH-012
HAGH-013

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HAGH-001
ENSP00000380514
ENST00000397356
Q16775 [Direct mapping]
Hydroxyacylglutathione hydrolase, mitochondrial
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0004416 [hydroxyacylglutathione hydrolase activity]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006090 [pyruvate metabolic process]
GO:0006749 [glutathione metabolic process]
GO:0006750 [glutathione biosynthetic process]
GO:0019243 [methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0070062 [extracellular exosome]
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 308 aa
33.8 kDa 		No 0
HAGH-002
ENSP00000380511
ENST00000397353
Q16775 [Direct mapping]
Hydroxyacylglutathione hydrolase, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004416 [hydroxyacylglutathione hydrolase activity]
GO:0005737 [cytoplasm]
GO:0005759 [mitochondrial matrix]
GO:0005829 [cytosol]
GO:0006090 [pyruvate metabolic process]
GO:0006750 [glutathione biosynthetic process]
GO:0019243 [methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0070062 [extracellular exosome]
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 260 aa
28.9 kDa 		No 0
HAGH-003
ENSP00000455422
ENST00000566709
H3BPQ4 [Direct mapping]
Hydroxyacylglutathione hydrolase, mitochondrial
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0004416 [hydroxyacylglutathione hydrolase activity]
GO:0019243 [methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione]
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 258 aa
27.9 kDa 		No 0
HAGH-004
ENSP00000406552
ENST00000455446
Q16775 [Direct mapping]
Hydroxyacylglutathione hydrolase, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004416 [hydroxyacylglutathione hydrolase activity]
GO:0005737 [cytoplasm]
GO:0005759 [mitochondrial matrix]
GO:0005829 [cytosol]
GO:0006090 [pyruvate metabolic process]
GO:0006750 [glutathione biosynthetic process]
GO:0019243 [methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0070062 [extracellular exosome]
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 236 aa
25.5 kDa 		No 0
HAGH-010
ENSP00000455970
ENST00000569339
H3BQW8 [Direct mapping]
Hydroxyacylglutathione hydrolase, mitochondrial
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 160 aa
17.3 kDa 		No 0
HAGH-012
ENSP00000455355
ENST00000564445
H3BPK3 [Direct mapping]
Hydroxyacylglutathione hydrolase, mitochondrial
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0004416 [hydroxyacylglutathione hydrolase activity]
GO:0019243 [methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione]
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 239 aa
26.3 kDa 		No 0
HAGH-013
ENSP00000457986
ENST00000566644
H3BV79 [Direct mapping]
Hydroxyacylglutathione hydrolase, mitochondrial
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 64 aa
7.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.