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RNF4

GENERAL INFORMATION

Gene name

 RNF4

Gene description

 Ring finger protein 4

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 11
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA049356
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PROGNOSTIC SUMMARY
Prognostic marker in lung cancer (unfavourable).
Lung cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA049356

GENE INFORMATION

Gene name

 RNF4 (HGNC Symbol)

Synonyms

 RES4-26, SLX5, SNURF

Description

 Ring finger protein 4 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene contains a RING finger motif and acts as a transcription regulator. This protein has been shown to interact with, and inhibit the activity of, TRPS1, a transcription suppressor of GATA-mediated transcription. Transcription repressor ZNF278/PATZ is found to interact with this protein, and thus reduce the enhancement of androgen receptor-dependent transcription mediated by this protein. Studies of the mouse and rat counterparts suggested a role of this protein in spermatogenesis. A pseudogene of this gene is found on chromosome 1.[provided by RefSeq, Jul 2010]

Chromosome

 4

Cytoband

 p16.3

Chromosome location (bp)

 2462220 - 2625320

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000063978 (version 83.38)

Entrez gene

 6047

UniProt

 P78317 (UniProt - Evidence at protein level)

neXtProt

 NX_P78317

Antibodypedia

 RNF4 antibodies

PROTEIN BROWSER
«
RNF4-001
RNF4-002
RNF4-003
RNF4-004
RNF4-005
RNF4-006
RNF4-008
RNF4-010
RNF4-020
RNF4-021
RNF4-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RNF4-001
ENSP00000315212
ENST00000314289
P78317 [Direct mapping]
E3 ubiquitin-protein ligase RNF4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000724 [double-strand break repair via homologous recombination]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006351 [transcription, DNA-templated]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0016567 [protein ubiquitination]
GO:0016605 [PML body]
GO:0016874 [ligase activity]
GO:0030521 [androgen receptor signaling pathway]
GO:0031491 [nucleosome binding]
GO:0032184 [SUMO polymer binding]
GO:0033234 [negative regulation of protein sumoylation]
GO:0033768 [SUMO-targeted ubiquitin ligase complex]
GO:0042802 [identical protein binding]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046685 [response to arsenic-containing substance]
GO:0050681 [androgen receptor binding]
GO:0051865 [protein autoubiquitination]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070534 [protein K63-linked ubiquitination]
GO:0070936 [protein K48-linked ubiquitination]
GO:0070979 [protein K11-linked ubiquitination]
GO:0085020 [protein K6-linked ubiquitination]
GO:0090169 [regulation of spindle assembly]
GO:0090234 [regulation of kinetochore assembly]
Show all
 190 aa
21.3 kDa 		No 0
RNF4-002
ENSP00000422500
ENST00000509258
D6RBZ1 [Direct mapping]
E3 ubiquitin-protein ligase RNF4
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 89 aa
10.3 kDa 		No 0
RNF4-003
ENSP00000424076
ENST00000506706
P78317 [Direct mapping]
E3 ubiquitin-protein ligase RNF4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000724 [double-strand break repair via homologous recombination]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006351 [transcription, DNA-templated]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0016567 [protein ubiquitination]
GO:0016605 [PML body]
GO:0016874 [ligase activity]
GO:0030521 [androgen receptor signaling pathway]
GO:0031491 [nucleosome binding]
GO:0032184 [SUMO polymer binding]
GO:0033234 [negative regulation of protein sumoylation]
GO:0033768 [SUMO-targeted ubiquitin ligase complex]
GO:0042802 [identical protein binding]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046685 [response to arsenic-containing substance]
GO:0050681 [androgen receptor binding]
GO:0051865 [protein autoubiquitination]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070534 [protein K63-linked ubiquitination]
GO:0070936 [protein K48-linked ubiquitination]
GO:0070979 [protein K11-linked ubiquitination]
GO:0085020 [protein K6-linked ubiquitination]
GO:0090169 [regulation of spindle assembly]
GO:0090234 [regulation of kinetochore assembly]
Show all
 190 aa
21.3 kDa 		No 0
RNF4-004
ENSP00000426615
ENST00000511859
P78317 [Direct mapping]
E3 ubiquitin-protein ligase RNF4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000724 [double-strand break repair via homologous recombination]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006351 [transcription, DNA-templated]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0016567 [protein ubiquitination]
GO:0016605 [PML body]
GO:0016874 [ligase activity]
GO:0030521 [androgen receptor signaling pathway]
GO:0031491 [nucleosome binding]
GO:0032184 [SUMO polymer binding]
GO:0033234 [negative regulation of protein sumoylation]
GO:0033768 [SUMO-targeted ubiquitin ligase complex]
GO:0042802 [identical protein binding]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046685 [response to arsenic-containing substance]
GO:0050681 [androgen receptor binding]
GO:0051865 [protein autoubiquitination]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070534 [protein K63-linked ubiquitination]
GO:0070936 [protein K48-linked ubiquitination]
GO:0070979 [protein K11-linked ubiquitination]
GO:0085020 [protein K6-linked ubiquitination]
GO:0090169 [regulation of spindle assembly]
GO:0090234 [regulation of kinetochore assembly]
Show all
 113 aa
12.1 kDa 		No 0
RNF4-005
ENSP00000426503
ENST00000511600
P78317 [Direct mapping]
E3 ubiquitin-protein ligase RNF4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000724 [double-strand break repair via homologous recombination]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006351 [transcription, DNA-templated]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0016567 [protein ubiquitination]
GO:0016605 [PML body]
GO:0016874 [ligase activity]
GO:0030521 [androgen receptor signaling pathway]
GO:0031491 [nucleosome binding]
GO:0032184 [SUMO polymer binding]
GO:0033234 [negative regulation of protein sumoylation]
GO:0033768 [SUMO-targeted ubiquitin ligase complex]
GO:0042802 [identical protein binding]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046685 [response to arsenic-containing substance]
GO:0050681 [androgen receptor binding]
GO:0051865 [protein autoubiquitination]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070534 [protein K63-linked ubiquitination]
GO:0070936 [protein K48-linked ubiquitination]
GO:0070979 [protein K11-linked ubiquitination]
GO:0085020 [protein K6-linked ubiquitination]
GO:0090169 [regulation of spindle assembly]
GO:0090234 [regulation of kinetochore assembly]
Show all
 190 aa
21.3 kDa 		No 0
RNF4-006
ENSP00000425667
ENST00000504224
D6RJF5 [Direct mapping]
E3 ubiquitin-protein ligase RNF4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 68 aa
7.5 kDa 		No 0
RNF4-008
ENSP00000423100
ENST00000502316
D6RA71 [Direct mapping]
E3 ubiquitin-protein ligase RNF4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0008270 [zinc ion binding]
Show all
 188 aa
21 kDa 		No 0
RNF4-010
ENSP00000423186
ENST00000503659
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 5 aa
0.6 kDa 		No 0
RNF4-020
ENSP00000422728
ENST00000507247
D6RAD8 [Direct mapping]
E3 ubiquitin-protein ligase RNF4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 102 aa
11.1 kDa 		No 0
RNF4-021
ENSP00000422619
ENST00000513450
D6RBQ7 [Direct mapping]
E3 ubiquitin-protein ligase RNF4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 54 aa
5.9 kDa 		No 0
RNF4-201
ENSP00000446369
ENST00000541204
P78317 [Direct mapping]
E3 ubiquitin-protein ligase RNF4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000724 [double-strand break repair via homologous recombination]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006351 [transcription, DNA-templated]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0016567 [protein ubiquitination]
GO:0016605 [PML body]
GO:0016874 [ligase activity]
GO:0030521 [androgen receptor signaling pathway]
GO:0031491 [nucleosome binding]
GO:0032184 [SUMO polymer binding]
GO:0033234 [negative regulation of protein sumoylation]
GO:0033768 [SUMO-targeted ubiquitin ligase complex]
GO:0042802 [identical protein binding]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046685 [response to arsenic-containing substance]
GO:0050681 [androgen receptor binding]
GO:0051865 [protein autoubiquitination]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070534 [protein K63-linked ubiquitination]
GO:0070936 [protein K48-linked ubiquitination]
GO:0070979 [protein K11-linked ubiquitination]
GO:0085020 [protein K6-linked ubiquitination]
GO:0090169 [regulation of spindle assembly]
GO:0090234 [regulation of kinetochore assembly]
Show all
 113 aa
12.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.