Expression of LIMCH1 in cancer - Summary - The Human Protein Atlas

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LIMCH1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	LIMCH1
Gene description	LIM and calponin homology domains 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	17
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (HeLa, RT4, WM-115)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification. Caution, Splice and/or transcript discrepancy exists.
Reliability score	Uncertain based on 2 antibodies. HPA004184 , HPA063840
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and breast cancer (unfavourable).
Renal cancer p<0.001 Breast cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA004184	HPA063840

GENE INFORMATION
Gene name	LIMCH1 (HGNC Symbol)
Synonyms	DKFZP686A01247, LIMCH1A, LMO7B
Description	LIM and calponin homology domains 1 (HGNC Symbol)
Entrez gene summary
Chromosome	4
Cytoband	p13
Chromosome location (bp)	41359607 - 41700044
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000064042 (version 83.38)
Entrez gene	22998
UniProt	Q9UPQ0 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UPQ0
Antibodypedia	LIMCH1 antibodies

PROTEIN BROWSER

LIMCH1-001	LIMCH1-002	LIMCH1-003	LIMCH1-004	LIMCH1-005	LIMCH1-006	LIMCH1-007	LIMCH1-010	LIMCH1-012	LIMCH1-013	LIMCH1-014	LIMCH1-015	LIMCH1-016	LIMCH1-017	LIMCH1-018	LIMCH1-019	LIMCH1-026

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LIMCH1-001 ENSP00000316891 ENST00000313860	Q9UPQ0 [Direct mapping] LIM and calponin homology domains-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0008270 [zinc ion binding] GO:0031032 [actomyosin structure organization] Show all	1083 aa 121.9 kDa	No	0
LIMCH1-002 ENSP00000424825 ENST00000508501	Q9UPQ0 [Direct mapping] LIM and calponin homology domains-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0008270 [zinc ion binding] GO:0031032 [actomyosin structure organization] Show all	1056 aa 118.9 kDa	No	0
LIMCH1-003 ENSP00000425222 ENST00000513024	Q9UPQ0 [Direct mapping] LIM and calponin homology domains-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0008270 [zinc ion binding] GO:0031032 [actomyosin structure organization] Show all	910 aa 103 kDa	No	0
LIMCH1-004 ENSP00000427311 ENST00000509638	D6RJ93 [Direct mapping] LIM and calponin homology domains-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		153 aa 17.3 kDa	No	0
LIMCH1-005 ENSP00000424645 ENST00000512946	Q9UPQ0 [Direct mapping] LIM and calponin homology domains-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0008270 [zinc ion binding] GO:0031032 [actomyosin structure organization] Show all	1057 aa 119.1 kDa	No	0
LIMCH1-006 ENSP00000427045 ENST00000512632	D6RD46 [Direct mapping] LIM and calponin homology domains-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0008270 [zinc ion binding] GO:0031032 [actomyosin structure organization] Show all	980 aa 109.9 kDa	No	0
LIMCH1-007 ENSP00000424437 ENST00000512820	Q9UPQ0 [Direct mapping] LIM and calponin homology domains-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0008270 [zinc ion binding] GO:0031032 [actomyosin structure organization] Show all	1069 aa 120.5 kDa	No	0
LIMCH1-010 ENSP00000411020 ENST00000446625	D6R8Y0 [Direct mapping] LIM and calponin homology domains-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		126 aa 14.1 kDa	No	0
LIMCH1-012 ENSP00000421242 ENST00000511496	Q9UPQ0 [Direct mapping] LIM and calponin homology domains-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0008270 [zinc ion binding] GO:0031032 [actomyosin structure organization] Show all	897 aa 101.5 kDa	No	0
LIMCH1-013 ENSP00000425631 ENST00000503057	G5EA03 [Direct mapping] LIM and calponin homology domains-containing protein 1; Uncharacterized protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008270 [zinc ion binding] Show all	1467 aa 164.4 kDa	No	0
LIMCH1-014 ENSP00000426334 ENST00000514096	E7EPK0 [Direct mapping] LIM and calponin homology domains-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008270 [zinc ion binding] Show all	897 aa 101.8 kDa	No	0
LIMCH1-015 ENSP00000422864 ENST00000509277	E9PDJ9 [Direct mapping] LIM and calponin homology domains-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008270 [zinc ion binding] Show all	916 aa 103.5 kDa	No	0
LIMCH1-016 ENSP00000423355 ENST00000509454	Q6NVB9 [Direct mapping] LIM and calponin homology domains-containing protein 1; LIMCH1 protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		160 aa 18.1 kDa	No	0
LIMCH1-017 ENSP00000379840 ENST00000396595	Q9UPQ0 [Direct mapping] LIM and calponin homology domains-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0008270 [zinc ion binding] GO:0031032 [actomyosin structure organization] Show all	902 aa 102 kDa	No	0
LIMCH1-018 ENSP00000371172 ENST00000381753	Q9UPQ0 [Direct mapping] LIM and calponin homology domains-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0008270 [zinc ion binding] GO:0031032 [actomyosin structure organization] Show all	890 aa 100.7 kDa	No	0
LIMCH1-019 ENSP00000421656 ENST00000508466	H0Y8P3 [Direct mapping] LIM and calponin homology domains-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008270 [zinc ion binding] Show all	917 aa 103.4 kDa	No	0
LIMCH1-026 ENSP00000426353 ENST00000511424	D6RGH8 [Direct mapping] LIM and calponin homology domains-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		26 aa 3.1 kDa	No	0

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The Human Protein Atlas

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