Expression of ASUN in cancer - Summary - The Human Protein Atlas

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ASUN

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ASUN
Gene description	Asunder spermatogenesis regulator
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA039543
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and renal cancer (unfavourable).
Liver cancer p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA039543

GENE INFORMATION
Gene name	ASUN (HGNC Symbol)
Synonyms	C12orf11, FLJ10637, Mat89Bb, NET48, SPATA30
Description	Asunder spermatogenesis regulator (HGNC Symbol)
Entrez gene summary
Chromosome	12
Cytoband	p11.23
Chromosome location (bp)	26905181 - 26938326
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000064102 (version 83.38)
Entrez gene	55726
UniProt	Q9NVM9 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NVM9
Antibodypedia	ASUN antibodies

PROTEIN BROWSER

ASUN-001	ASUN-002	ASUN-004	ASUN-007	ASUN-008	ASUN-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ASUN-001 ENSP00000261191 ENST00000261191	Q9NVM9 [Direct mapping] Protein asunder homolog Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0007052 [mitotic spindle organization] GO:0007067 [mitotic nuclear division] GO:0007346 [regulation of mitotic cell cycle] GO:0030317 [sperm motility] GO:0051301 [cell division] GO:0051642 [centrosome localization] GO:0080154 [regulation of fertilization] GO:0090435 [protein localization to nuclear envelope] Show all	706 aa 80.2 kDa	No	0
ASUN-002 ENSP00000445645 ENST00000538155	H0YH12 [Direct mapping] Protein asunder homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		353 aa 40 kDa	No	0
ASUN-004 ENSP00000448985 ENST00000536232	H0YIA9 [Direct mapping] Protein asunder homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		153 aa 17.4 kDa	No	0
ASUN-007 ENSP00000443066 ENST00000537336	F5H5W1 [Direct mapping] Protein asunder homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		163 aa 18.4 kDa	No	0
ASUN-008 ENSP00000446183 ENST00000544548	F5H457 [Direct mapping] Protein asunder homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		225 aa 25.5 kDa	No	0
ASUN-009 ENSP00000448467 ENST00000538727	F8VRX9 [Direct mapping] Protein asunder homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		124 aa 13.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.