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SPA17

GENERAL INFORMATION

Gene name

 SPA17

Gene description

 Sperm autoantigenic protein 17

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Group enriched (fallopian tube, testis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic staining in cells of seminiferous ducts and in cilia.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 1 antibody.
HPA037568
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable).
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA037568

GENE INFORMATION

Gene name

 SPA17 (HGNC Symbol)

Synonyms

 CT22, SP17

Description

 Sperm autoantigenic protein 17 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein present at the cell surface. The N-terminus has sequence similarity to human cAMP-dependent protein kinase A (PKA) type II alpha regulatory subunit (RIIa) while the C-terminus has an IQ calmodulin-binding motif. The central portion of the protein has carbohydrate binding motifs and likely functions in cell-cell adhesion. The protein was initially characterized by its involvement in the binding of sperm to the zona pellucida of the oocyte. Recent studies indicate that it is also involved in additional cell-cell adhesion functions such as immune cell migration and metastasis. A retrotransposed pseudogene is present on chromosome 10q22.[provided by RefSeq, Jan 2009]

Chromosome

 11

Cytoband

 q24.2

Chromosome location (bp)

 124673798 - 124697518

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000064199 (version 83.38)

Entrez gene

 53340

UniProt

 Q15506 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15506

Antibodypedia

 SPA17 antibodies

PROTEIN BROWSER
SPA17-001
SPA17-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SPA17-001
ENSP00000432305
ENST00000532692
Q15506 [Direct mapping]
Sperm surface protein Sp17
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003351 [epithelial cilium movement]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005737 [cytoplasm]
GO:0005929 [cilium]
GO:0007283 [spermatogenesis]
GO:0007338 [single fertilization]
GO:0007339 [binding of sperm to zona pellucida]
GO:0009897 [external side of plasma membrane]
GO:0016020 [membrane]
GO:0031514 [motile cilium]
GO:0035686 [sperm fibrous sheath]
GO:0072372 [primary cilium]
GO:0097228 [sperm principal piece]
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 151 aa
17.4 kDa 		No 0
SPA17-004
ENSP00000227135
ENST00000227135
Q15506 [Direct mapping]
Sperm surface protein Sp17
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003351 [epithelial cilium movement]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005737 [cytoplasm]
GO:0007283 [spermatogenesis]
GO:0007338 [single fertilization]
GO:0007339 [binding of sperm to zona pellucida]
GO:0016020 [membrane]
GO:0031514 [motile cilium]
GO:0035686 [sperm fibrous sheath]
GO:0072372 [primary cilium]
GO:0097228 [sperm principal piece]
Show all
 151 aa
17.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.