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Moderate to strong nuclear immunoreactivity was observed in malignant gliomas and a few breast, ovarian and renal cancers. Most other malignant cells were weakly stained or negative.
GENE INFORMATION
Gene name
HIPK2
Synonyms
Description
Homeodomain interacting protein kinase 2 (HGNC Symbol)
Entrez gene summary
This gene encodes a conserved serine/threonine kinase that is a member of the homeodomain-interacting protein kinase family. The encoded protein interacts with homeodomain transcription factors and many other transcription factors such as p53, and can function as both a corepressor and a coactivator depending on the transcription factor and its subcellular localization. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]