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TNPO3

GENERAL INFORMATION

Gene name

 TNPO3

Gene description

 Transportin 3

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA039555
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA039555

GENE INFORMATION

Gene name

 TNPO3 (HGNC Symbol)

Synonyms

 IPO12, LGMD1F, MTR10A, TRN-SR, TRN-SR2

Description

 Transportin 3 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a nuclear import receptor for serine/arginine-rich (SR) proteins such as the splicing factors SFRS1 and SFRS2. The encoded protein has also been shown to be involved in HIV-1 infection, apparently through interaction with the HIV-1 capsid protein. Two transcript variants encoding different isoforms as well as a noncoding transcript have been found for this gene.[provided by RefSeq, Jul 2010]

Chromosome

 7

Cytoband

 q32.1

Chromosome location (bp)

 128954180 - 129055173

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000064419 (version 83.38)

Entrez gene

 23534

UniProt

 Q9Y5L0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y5L0

Antibodypedia

 TNPO3 antibodies

PROTEIN BROWSER
TNPO3-001
TNPO3-002
TNPO3-003
TNPO3-005
TNPO3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TNPO3-001
ENSP00000265388
ENST00000265388
Q9Y5L0 [Direct mapping]
Transportin-3
A0A024R794 [Target identity:100%; Query identity:100%]
Transportin 3, isoform CRA_b
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004872 [receptor activity]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0008139 [nuclear localization sequence binding]
GO:0008565 [protein transporter activity]
GO:0031965 [nuclear membrane]
GO:0035048 [splicing factor protein import into nucleus]
GO:0042802 [identical protein binding]
GO:0043231 [intracellular membrane-bounded organelle]
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 923 aa
104.2 kDa 		No 0
TNPO3-002
ENSP00000420089
ENST00000482320
E9PFH4 [Direct mapping]
Transportin-3
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
 857 aa
96.7 kDa 		No 0
TNPO3-003
ENSP00000418646
ENST00000471234
Q9Y5L0 [Direct mapping]
Transportin-3
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004872 [receptor activity]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0008139 [nuclear localization sequence binding]
GO:0008565 [protein transporter activity]
GO:0031965 [nuclear membrane]
GO:0035048 [splicing factor protein import into nucleus]
GO:0042802 [identical protein binding]
GO:0043231 [intracellular membrane-bounded organelle]
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 859 aa
97.4 kDa 		No 0
TNPO3-005
ENSP00000418267
ENST00000471166
C9J7E5 [Direct mapping]
Transportin-3
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
 957 aa
108 kDa 		No 0
TNPO3-201
ENSP00000487231
ENST00000627585
C9J7E5 [Direct mapping]
Transportin-3
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
 957 aa
108 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.