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Most cancer cells showed moderate to strong cytoplasmic positivity. Several cases of lymphoma were negative.
GENE INFORMATION
Gene name
CTSA (HGNC Symbol)
Synonyms
GSL, PPGB
Description
Cathepsin A (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the peptidase S10 family of serine carboxypeptidases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate two chains that comprise the heterodimeric active enzyme. This enzyme possesses deamidase, esterase and carboxypeptidase activities and acts as a scaffold in the lysosomal multienzyme complex. Mutations in this gene are associated with galactosialidosis. [provided by RefSeq, Nov 2015]