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SLC12A2

GENERAL INFORMATION

Gene name

 SLC12A2

Gene description

 Solute carrier family 12 (sodium/potassium/chloride transporter), member 2

Protein class

 FDA approved drug targets
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA020130
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and endometrial cancer (favourable).
Renal cancer p<0.001
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA020130

GENE INFORMATION

Gene name

 SLC12A2 (HGNC Symbol)

Synonyms

 BSC, BSC2, NKCC1, PPP1R141

Description

 Solute carrier family 12 (sodium/potassium/chloride transporter), member 2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene mediates sodium and chloride transport and reabsorption. The encoded protein is a membrane protein and is important in maintaining proper ionic balance and cell volume. This protein is phosphorylated in response to DNA damage. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Chromosome

 5

Cytoband

 q23.3

Chromosome location (bp)

 128083766 - 128189688

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000064651 (version 83.38)

Entrez gene

 6558

UniProt

 P55011 (UniProt - Evidence at protein level)

neXtProt

 NX_P55011

Antibodypedia

 SLC12A2 antibodies

PROTEIN BROWSER
SLC12A2-001
SLC12A2-004
SLC12A2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC12A2-001
ENSP00000262461
ENST00000262461
P55011 [Direct mapping]
Solute carrier family 12 member 2
Q53ZR1 [Target identity:100%; Query identity:100%]
Bumetanide-sensitive Na-K-Cl cotransporter; Solute carrier family 12 (Sodium/potassium/chloride transporters), member 2, isoform CRA_b
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Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006884 [cell volume homeostasis]
GO:0008511 [sodium:potassium:chloride symporter activity]
GO:0008519 [ammonium transmembrane transporter activity]
GO:0010107 [potassium ion import]
GO:0015081 [sodium ion transmembrane transporter activity]
GO:0015377 [cation:chloride symporter activity]
GO:0015378 [sodium:chloride symporter activity]
GO:0015379 [potassium:chloride symporter activity]
GO:0015696 [ammonium transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0022820 [potassium ion symporter activity]
GO:0030321 [transepithelial chloride transport]
GO:0035264 [multicellular organism growth]
GO:0035725 [sodium ion transmembrane transport]
GO:0050910 [detection of mechanical stimulus involved in sensory perception of sound]
GO:0055064 [chloride ion homeostasis]
GO:0055075 [potassium ion homeostasis]
GO:0055078 [sodium ion homeostasis]
GO:0055085 [transmembrane transport]
GO:0060444 [branching involved in mammary gland duct morphogenesis]
GO:0060763 [mammary duct terminal end bud growth]
GO:0070062 [extracellular exosome]
GO:0070634 [transepithelial ammonium transport]
GO:0072488 [ammonium transmembrane transport]
GO:1902476 [chloride transmembrane transport]
GO:1903561 [extracellular vesicle]
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 1212 aa
131.4 kDa 		No >9
SLC12A2-004
ENSP00000340878
ENST00000343225
P55011 [Direct mapping]
Solute carrier family 12 member 2
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Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006884 [cell volume homeostasis]
GO:0008511 [sodium:potassium:chloride symporter activity]
GO:0008519 [ammonium transmembrane transporter activity]
GO:0010107 [potassium ion import]
GO:0015081 [sodium ion transmembrane transporter activity]
GO:0015377 [cation:chloride symporter activity]
GO:0015378 [sodium:chloride symporter activity]
GO:0015379 [potassium:chloride symporter activity]
GO:0015696 [ammonium transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0022820 [potassium ion symporter activity]
GO:0030321 [transepithelial chloride transport]
GO:0035725 [sodium ion transmembrane transport]
GO:0055064 [chloride ion homeostasis]
GO:0055075 [potassium ion homeostasis]
GO:0055078 [sodium ion homeostasis]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0070634 [transepithelial ammonium transport]
GO:0072488 [ammonium transmembrane transport]
GO:1902476 [chloride transmembrane transport]
GO:1903561 [extracellular vesicle]
Show all
 1196 aa
129.7 kDa 		No >9
SLC12A2-201
ENSP00000486323
ENST00000628403
G3XAL9 [Direct mapping]
Solute carrier family 12 (Sodium/potassium/chloride transporters), member 2, isoform CRA_a; Solute carrier family 12 member 2
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0015377 [cation:chloride symporter activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0055085 [transmembrane transport]
GO:1902476 [chloride transmembrane transport]
Show all
 1150 aa
124.6 kDa 		No >9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.