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ABCA7

GENERAL INFORMATION

Gene name

 ABCA7

Gene description

 ATP-binding cassette, sub-family A (ABC1), member 7

Protein class

 Predicted intracellular proteins
Predicted membrane proteins
Transporters

Predicted localization

 Intracellular,Membrane

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (HMC-1)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in bone marrow and in subsets of immune cells in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 1 antibody.
HPA041564
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable) and colorectal cancer (unfavourable).
Endometrial cancer p<0.001
Colorectal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA041564

GENE INFORMATION

Gene name

 ABCA7 (HGNC Symbol)

Synonyms

 ABCX

Description

 ATP-binding cassette, sub-family A (ABC1), member 7 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This full transporter has been detected predominantly in myelo-lymphatic tissues with the highest expression in peripheral leukocytes, thymus, spleen, and bone marrow. The function of this protein is not yet known; however, the expression pattern suggests a role in lipid homeostasis in cells of the immune system. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 p13.3

Chromosome location (bp)

 1040101 - 1065572

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000064687 (version 83.38)

Entrez gene

 10347

UniProt

 Q8IZY2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8IZY2

Antibodypedia

 ABCA7 antibodies

PROTEIN BROWSER
ABCA7-001
ABCA7-002
ABCA7-006
ABCA7-007
ABCA7-012
ABCA7-013
ABCA7-018
ABCA7-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ABCA7-001
ENSP00000414062
ENST00000433129
Q8IZY2 [Direct mapping]
ATP-binding cassette sub-family A member 7
Show all
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Show all
GO:0000139 [Golgi membrane]
GO:0001891 [phagocytic cup]
GO:0005215 [transporter activity]
GO:0005524 [ATP binding]
GO:0005548 [phospholipid transporter activity]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006909 [phagocytosis]
GO:0007613 [memory]
GO:0009986 [cell surface]
GO:0010008 [endosome membrane]
GO:0010875 [positive regulation of cholesterol efflux]
GO:0016021 [integral component of membrane]
GO:0016887 [ATPase activity]
GO:0017121 [phospholipid scrambling]
GO:0017127 [cholesterol transporter activity]
GO:0018149 [peptide cross-linking]
GO:0032587 [ruffle membrane]
GO:0032780 [negative regulation of ATPase activity]
GO:0032781 [positive regulation of ATPase activity]
GO:0033344 [cholesterol efflux]
GO:0033700 [phospholipid efflux]
GO:0034188 [apolipoprotein A-I receptor activity]
GO:0034380 [high-density lipoprotein particle assembly]
GO:0034504 [protein localization to nucleus]
GO:0038027 [apolipoprotein A-I-mediated signaling pathway]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0042985 [negative regulation of amyloid precursor protein biosynthetic process]
GO:0043190 [ATP-binding cassette (ABC) transporter complex]
GO:0050766 [positive regulation of phagocytosis]
GO:0055085 [transmembrane transport]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:1900223 [positive regulation of beta-amyloid clearance]
GO:1901076 [positive regulation of engulfment of apoptotic cell]
GO:1902430 [negative regulation of beta-amyloid formation]
GO:1902995 [positive regulation of phospholipid efflux]
Show all
 2146 aa
234.3 kDa 		No >9
ABCA7-002
ENSP00000465322
ENST00000435683
Q8IZY2 [Direct mapping]
ATP-binding cassette sub-family A member 7
Show all
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Show all
GO:0000139 [Golgi membrane]
GO:0001891 [phagocytic cup]
GO:0005215 [transporter activity]
GO:0005524 [ATP binding]
GO:0005548 [phospholipid transporter activity]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006909 [phagocytosis]
GO:0007613 [memory]
GO:0009986 [cell surface]
GO:0010008 [endosome membrane]
GO:0010875 [positive regulation of cholesterol efflux]
GO:0016021 [integral component of membrane]
GO:0016887 [ATPase activity]
GO:0017121 [phospholipid scrambling]
GO:0017127 [cholesterol transporter activity]
GO:0018149 [peptide cross-linking]
GO:0032587 [ruffle membrane]
GO:0032780 [negative regulation of ATPase activity]
GO:0032781 [positive regulation of ATPase activity]
GO:0033344 [cholesterol efflux]
GO:0033700 [phospholipid efflux]
GO:0034188 [apolipoprotein A-I receptor activity]
GO:0034380 [high-density lipoprotein particle assembly]
GO:0034504 [protein localization to nucleus]
GO:0038027 [apolipoprotein A-I-mediated signaling pathway]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0042985 [negative regulation of amyloid precursor protein biosynthetic process]
GO:0043190 [ATP-binding cassette (ABC) transporter complex]
GO:0050766 [positive regulation of phagocytosis]
GO:0055085 [transmembrane transport]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:1900223 [positive regulation of beta-amyloid clearance]
GO:1901076 [positive regulation of engulfment of apoptotic cell]
GO:1902430 [negative regulation of beta-amyloid formation]
GO:1902995 [positive regulation of phospholipid efflux]
Show all
 2008 aa
218.5 kDa 		No >9
ABCA7-006
ENSP00000431473
ENST00000524850
E9PL63 [Direct mapping]
ATP-binding cassette sub-family A member 7
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Show all
GO:0005548 [phospholipid transporter activity]
GO:0005887 [integral component of plasma membrane]
GO:0006909 [phagocytosis]
GO:0015914 [phospholipid transport]
GO:0017127 [cholesterol transporter activity]
GO:0030301 [cholesterol transport]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0055085 [transmembrane transport]
Show all
 164 aa
18.4 kDa 		No 0
ABCA7-007
ENSP00000433545
ENST00000531467
E9PKG5 [Direct mapping]
ATP-binding cassette sub-family A member 7
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Show all
GO:0005548 [phospholipid transporter activity]
GO:0005887 [integral component of plasma membrane]
GO:0006909 [phagocytosis]
GO:0015914 [phospholipid transport]
GO:0017127 [cholesterol transporter activity]
GO:0030301 [cholesterol transport]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0055085 [transmembrane transport]
Show all
 136 aa
15.4 kDa 		No 0
ABCA7-012
ENSP00000482948
ENST00000612569
A0A087WZX6 [Direct mapping]
ATP-binding cassette sub-family A member 7
Show all
Predicted intracellular proteins
Show all
GO:0005524 [ATP binding]
GO:0005548 [phospholipid transporter activity]
GO:0005887 [integral component of plasma membrane]
GO:0006909 [phagocytosis]
GO:0008152 [metabolic process]
GO:0015914 [phospholipid transport]
GO:0016887 [ATPase activity]
GO:0017127 [cholesterol transporter activity]
GO:0030301 [cholesterol transport]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0055085 [transmembrane transport]
Show all
 280 aa
30 kDa 		No 0
ABCA7-013
ENSP00000432031
ENST00000525073
H0YCN5 [Direct mapping]
ATP-binding cassette sub-family A member 7
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Show all
GO:0005524 [ATP binding]
GO:0005548 [phospholipid transporter activity]
GO:0005887 [integral component of plasma membrane]
GO:0006909 [phagocytosis]
GO:0008152 [metabolic process]
GO:0015914 [phospholipid transport]
GO:0016887 [ATPase activity]
GO:0017127 [cholesterol transporter activity]
GO:0030301 [cholesterol transport]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0055085 [transmembrane transport]
Show all
 591 aa
64.5 kDa 		No 4
ABCA7-018
ENSP00000478857
ENST00000611490
A0A087WUR5 [Direct mapping]
ATP-binding cassette sub-family A member 7
Show all
Predicted intracellular proteins
Show all
GO:0005548 [phospholipid transporter activity]
GO:0005887 [integral component of plasma membrane]
GO:0006909 [phagocytosis]
GO:0015914 [phospholipid transport]
GO:0017127 [cholesterol transporter activity]
GO:0030301 [cholesterol transport]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0055085 [transmembrane transport]
Show all
 36 aa
4.6 kDa 		No 0
ABCA7-201
ENSP00000263094
ENST00000263094
Q8IZY2 [Direct mapping]
ATP-binding cassette sub-family A member 7
Show all
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0001891 [phagocytic cup]
GO:0005215 [transporter activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005548 [phospholipid transporter activity]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006909 [phagocytosis]
GO:0007613 [memory]
GO:0009986 [cell surface]
GO:0010008 [endosome membrane]
GO:0010875 [positive regulation of cholesterol efflux]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0016887 [ATPase activity]
GO:0017121 [phospholipid scrambling]
GO:0017127 [cholesterol transporter activity]
GO:0018149 [peptide cross-linking]
GO:0032587 [ruffle membrane]
GO:0032780 [negative regulation of ATPase activity]
GO:0032781 [positive regulation of ATPase activity]
GO:0033344 [cholesterol efflux]
GO:0033700 [phospholipid efflux]
GO:0034188 [apolipoprotein A-I receptor activity]
GO:0034380 [high-density lipoprotein particle assembly]
GO:0034504 [protein localization to nucleus]
GO:0038027 [apolipoprotein A-I-mediated signaling pathway]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0042985 [negative regulation of amyloid precursor protein biosynthetic process]
GO:0043190 [ATP-binding cassette (ABC) transporter complex]
GO:0050766 [positive regulation of phagocytosis]
GO:0055085 [transmembrane transport]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:1900223 [positive regulation of beta-amyloid clearance]
GO:1901076 [positive regulation of engulfment of apoptotic cell]
GO:1902430 [negative regulation of beta-amyloid formation]
GO:1902995 [positive regulation of phospholipid efflux]
Show all
 2146 aa
234.3 kDa 		No >9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.