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Gene name

Class

Subclass

Chromosome

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In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

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Score

Score

Score

Antibodies

Column

 
 
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ABCA7
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    TISSUE

  • premium

    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

ABCA7

Gene description

ATP-binding cassette, sub-family A (ABC1), member 7

Protein class

Predicted intracellular proteins
Predicted membrane proteins
Transporters

Predicted localization

Intracellular,Membrane

Number of transcripts

8
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (HMC-1)
HPA (normal tissue):Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in bone marrow and in subsets of immune cells in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

Supported based on 1 antibody.
HPA041564
SHOW MORE

PROGNOSTIC SUMMARY

Prognostic marker in endometrial cancer (favourable) and colorectal cancer (unfavourable).
Endometrial cancer p<0.001
Colorectal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA041564

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Weak to moderate cytoplasmic positivity, often with a granular pattern, was observed in several cases of most cancer types. Inflammatory cells were strongly stained.

GENE INFORMATION

Gene name

ABCA7 (HGNC Symbol)

Synonyms

ABCX

Description

ATP-binding cassette, sub-family A (ABC1), member 7 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This full transporter has been detected predominantly in myelo-lymphatic tissues with the highest expression in peripheral leukocytes, thymus, spleen, and bone marrow. The function of this protein is not yet known; however, the expression pattern suggests a role in lipid homeostasis in cells of the immune system. [provided by RefSeq, Jul 2008]

Chromosome

19

Cytoband

p13.3

Chromosome location (bp)

1040101 - 1065572

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000064687 (version 83.38)

Entrez gene

10347

UniProt

Q8IZY2 (UniProt - Evidence at protein level)

neXtProt

NX_Q8IZY2

Antibodypedia

ABCA7 antibodies

PROTEIN BROWSER

ABCA7-001
ABCA7-002
ABCA7-006
ABCA7-007
ABCA7-012
ABCA7-013
ABCA7-018
ABCA7-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ABCA7-001
ENSP00000414062
ENST00000433129
Q8IZY2 [Direct mapping]
ATP-binding cassette sub-family A member 7
Show all
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Show all
GO:0000139 [Golgi membrane]
GO:0001891 [phagocytic cup]
GO:0005215 [transporter activity]
GO:0005524 [ATP binding]
GO:0005548 [phospholipid transporter activity]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006909 [phagocytosis]
GO:0007613 [memory]
GO:0009986 [cell surface]
GO:0010008 [endosome membrane]
GO:0010875 [positive regulation of cholesterol efflux]
GO:0016021 [integral component of membrane]
GO:0016887 [ATPase activity]
GO:0017121 [phospholipid scrambling]
GO:0017127 [cholesterol transporter activity]
GO:0018149 [peptide cross-linking]
GO:0032587 [ruffle membrane]
GO:0032780 [negative regulation of ATPase activity]
GO:0032781 [positive regulation of ATPase activity]
GO:0033344 [cholesterol efflux]
GO:0033700 [phospholipid efflux]
GO:0034188 [apolipoprotein A-I receptor activity]
GO:0034380 [high-density lipoprotein particle assembly]
GO:0034504 [protein localization to nucleus]
GO:0038027 [apolipoprotein A-I-mediated signaling pathway]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0042985 [negative regulation of amyloid precursor protein biosynthetic process]
GO:0043190 [ATP-binding cassette (ABC) transporter complex]
GO:0050766 [positive regulation of phagocytosis]
GO:0055085 [transmembrane transport]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:1900223 [positive regulation of beta-amyloid clearance]
GO:1901076 [positive regulation of engulfment of apoptotic cell]
GO:1902430 [negative regulation of beta-amyloid formation]
GO:1902995 [positive regulation of phospholipid efflux]
Show all
2146 aa
234.3 kDa
No >9
ABCA7-002
ENSP00000465322
ENST00000435683
Q8IZY2 [Direct mapping]
ATP-binding cassette sub-family A member 7
Show all
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Show all
GO:0000139 [Golgi membrane]
GO:0001891 [phagocytic cup]
GO:0005215 [transporter activity]
GO:0005524 [ATP binding]
GO:0005548 [phospholipid transporter activity]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006909 [phagocytosis]
GO:0007613 [memory]
GO:0009986 [cell surface]
GO:0010008 [endosome membrane]
GO:0010875 [positive regulation of cholesterol efflux]
GO:0016021 [integral component of membrane]
GO:0016887 [ATPase activity]
GO:0017121 [phospholipid scrambling]
GO:0017127 [cholesterol transporter activity]
GO:0018149 [peptide cross-linking]
GO:0032587 [ruffle membrane]
GO:0032780 [negative regulation of ATPase activity]
GO:0032781 [positive regulation of ATPase activity]
GO:0033344 [cholesterol efflux]
GO:0033700 [phospholipid efflux]
GO:0034188 [apolipoprotein A-I receptor activity]
GO:0034380 [high-density lipoprotein particle assembly]
GO:0034504 [protein localization to nucleus]
GO:0038027 [apolipoprotein A-I-mediated signaling pathway]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0042985 [negative regulation of amyloid precursor protein biosynthetic process]
GO:0043190 [ATP-binding cassette (ABC) transporter complex]
GO:0050766 [positive regulation of phagocytosis]
GO:0055085 [transmembrane transport]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:1900223 [positive regulation of beta-amyloid clearance]
GO:1901076 [positive regulation of engulfment of apoptotic cell]
GO:1902430 [negative regulation of beta-amyloid formation]
GO:1902995 [positive regulation of phospholipid efflux]
Show all
2008 aa
218.5 kDa
No >9
ABCA7-006
ENSP00000431473
ENST00000524850
E9PL63 [Direct mapping]
ATP-binding cassette sub-family A member 7
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Show all
GO:0005548 [phospholipid transporter activity]
GO:0005887 [integral component of plasma membrane]
GO:0006909 [phagocytosis]
GO:0015914 [phospholipid transport]
GO:0017127 [cholesterol transporter activity]
GO:0030301 [cholesterol transport]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0055085 [transmembrane transport]
Show all
164 aa
18.4 kDa
No 0
ABCA7-007
ENSP00000433545
ENST00000531467
E9PKG5 [Direct mapping]
ATP-binding cassette sub-family A member 7
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Show all
GO:0005548 [phospholipid transporter activity]
GO:0005887 [integral component of plasma membrane]
GO:0006909 [phagocytosis]
GO:0015914 [phospholipid transport]
GO:0017127 [cholesterol transporter activity]
GO:0030301 [cholesterol transport]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0055085 [transmembrane transport]
Show all
136 aa
15.4 kDa
No 0
ABCA7-012
ENSP00000482948
ENST00000612569
A0A087WZX6 [Direct mapping]
ATP-binding cassette sub-family A member 7
Show all
Predicted intracellular proteins
Show all
GO:0005524 [ATP binding]
GO:0005548 [phospholipid transporter activity]
GO:0005887 [integral component of plasma membrane]
GO:0006909 [phagocytosis]
GO:0008152 [metabolic process]
GO:0015914 [phospholipid transport]
GO:0016887 [ATPase activity]
GO:0017127 [cholesterol transporter activity]
GO:0030301 [cholesterol transport]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0055085 [transmembrane transport]
Show all
280 aa
30 kDa
No 0
ABCA7-013
ENSP00000432031
ENST00000525073
H0YCN5 [Direct mapping]
ATP-binding cassette sub-family A member 7
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Show all
GO:0005524 [ATP binding]
GO:0005548 [phospholipid transporter activity]
GO:0005887 [integral component of plasma membrane]
GO:0006909 [phagocytosis]
GO:0008152 [metabolic process]
GO:0015914 [phospholipid transport]
GO:0016887 [ATPase activity]
GO:0017127 [cholesterol transporter activity]
GO:0030301 [cholesterol transport]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0055085 [transmembrane transport]
Show all
591 aa
64.5 kDa
No 4
ABCA7-018
ENSP00000478857
ENST00000611490
A0A087WUR5 [Direct mapping]
ATP-binding cassette sub-family A member 7
Show all
Predicted intracellular proteins
Show all
GO:0005548 [phospholipid transporter activity]
GO:0005887 [integral component of plasma membrane]
GO:0006909 [phagocytosis]
GO:0015914 [phospholipid transport]
GO:0017127 [cholesterol transporter activity]
GO:0030301 [cholesterol transport]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0055085 [transmembrane transport]
Show all
36 aa
4.6 kDa
No 0
ABCA7-201
ENSP00000263094
ENST00000263094
Q8IZY2 [Direct mapping]
ATP-binding cassette sub-family A member 7
Show all
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0001891 [phagocytic cup]
GO:0005215 [transporter activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005548 [phospholipid transporter activity]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006909 [phagocytosis]
GO:0007613 [memory]
GO:0009986 [cell surface]
GO:0010008 [endosome membrane]
GO:0010875 [positive regulation of cholesterol efflux]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0016887 [ATPase activity]
GO:0017121 [phospholipid scrambling]
GO:0017127 [cholesterol transporter activity]
GO:0018149 [peptide cross-linking]
GO:0032587 [ruffle membrane]
GO:0032780 [negative regulation of ATPase activity]
GO:0032781 [positive regulation of ATPase activity]
GO:0033344 [cholesterol efflux]
GO:0033700 [phospholipid efflux]
GO:0034188 [apolipoprotein A-I receptor activity]
GO:0034380 [high-density lipoprotein particle assembly]
GO:0034504 [protein localization to nucleus]
GO:0038027 [apolipoprotein A-I-mediated signaling pathway]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0042985 [negative regulation of amyloid precursor protein biosynthetic process]
GO:0043190 [ATP-binding cassette (ABC) transporter complex]
GO:0050766 [positive regulation of phagocytosis]
GO:0055085 [transmembrane transport]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:1900223 [positive regulation of beta-amyloid clearance]
GO:1901076 [positive regulation of engulfment of apoptotic cell]
GO:1902430 [negative regulation of beta-amyloid formation]
GO:1902995 [positive regulation of phospholipid efflux]
Show all
2146 aa
234.3 kDa
No >9

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