Expression of CHI3L2 in cancer - Summary - The Human Protein Atlas

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CHI3L2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CHI3L2
Gene description	Chitinase 3-like 2
Protein class	Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	14
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (glioma)
HPA (cell line):	Cell line enriched (MOLT-4)
HPA (normal tissue):	Tissue enhanced (appendix)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Presumed off target binding observed and disregarded. Caution, Splice and/or transcript discrepancy exists.
Reliability score	Uncertain based on 1 antibody. HPA005443
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), glioma (unfavourable) and head and neck cancer (favourable).
Renal cancer p<0.001 Glioma p<0.001 Head and neck cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (glioma)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA005443

GENE INFORMATION
Gene name	CHI3L2 (HGNC Symbol)
Synonyms	YKL-39, YKL39
Description	Chitinase 3-like 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is similar to bacterial chitinases but lacks chitinase activity. The encoded protein is secreted and is involved in cartilage biogenesis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Chromosome	1
Cytoband	p13.2
Chromosome location (bp)	111200771 - 111243440
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000064886 (version 83.38)
Entrez gene	1117
UniProt	Q15782 (UniProt - Evidence at protein level)
neXtProt	NX_Q15782
Antibodypedia	CHI3L2 antibodies

PROTEIN BROWSER

CHI3L2-001	CHI3L2-002	CHI3L2-003	CHI3L2-004	CHI3L2-007	CHI3L2-008	CHI3L2-009	CHI3L2-010	CHI3L2-011	CHI3L2-012	CHI3L2-015	CHI3L2-016	CHI3L2-017	CHI3L2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CHI3L2-001 ENSP00000437082 ENST00000445067	Q15782 [Direct mapping] Chitinase-3-like protein 2 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004553 [hydrolase activity, hydrolyzing O-glycosyl compounds] GO:0004568 [chitinase activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005975 [carbohydrate metabolic process] GO:0006032 [chitin catabolic process] GO:0008061 [chitin binding] GO:0030246 [carbohydrate binding] Show all	390 aa 43.5 kDa	Yes	0
CHI3L2-002 ENSP00000437086 ENST00000466741	Q15782 [Direct mapping] Chitinase-3-like protein 2 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004553 [hydrolase activity, hydrolyzing O-glycosyl compounds] GO:0004568 [chitinase activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005975 [carbohydrate metabolic process] GO:0006032 [chitin catabolic process] GO:0008061 [chitin binding] GO:0030246 [carbohydrate binding] Show all	311 aa 34.6 kDa	No	0
CHI3L2-003 ENSP00000436272 ENST00000477185	E9PPX4 [Direct mapping] Chitinase-3-like protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004553 [hydrolase activity, hydrolyzing O-glycosyl compounds] GO:0004568 [chitinase activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005975 [carbohydrate metabolic process] GO:0006032 [chitin catabolic process] GO:0008061 [chitin binding] Show all	169 aa 19.3 kDa	No	0
CHI3L2-004 ENSP00000358759 ENST00000369744	Q15782 [Direct mapping] Chitinase-3-like protein 2 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004553 [hydrolase activity, hydrolyzing O-glycosyl compounds] GO:0004568 [chitinase activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005975 [carbohydrate metabolic process] GO:0006032 [chitin catabolic process] GO:0008061 [chitin binding] GO:0030246 [carbohydrate binding] Show all	380 aa 42.5 kDa	No	0
CHI3L2-007 ENSP00000435250 ENST00000497220	H0YE91 [Direct mapping] Chitinase-3-like protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004553 [hydrolase activity, hydrolyzing O-glycosyl compounds] GO:0004568 [chitinase activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005975 [carbohydrate metabolic process] GO:0006032 [chitin catabolic process] GO:0008061 [chitin binding] Show all	183 aa 20.7 kDa	No	0
CHI3L2-008 ENSP00000436380 ENST00000474304	E9PP75 [Direct mapping] Chitinase-3-like protein 2 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004553 [hydrolase activity, hydrolyzing O-glycosyl compounds] GO:0004568 [chitinase activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005975 [carbohydrate metabolic process] GO:0006032 [chitin catabolic process] GO:0008061 [chitin binding] Show all	182 aa 20.5 kDa	Yes	0
CHI3L2-009 ENSP00000431978 ENST00000467038	E9PII8 [Direct mapping] Chitinase-3-like protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004553 [hydrolase activity, hydrolyzing O-glycosyl compounds] GO:0004568 [chitinase activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005975 [carbohydrate metabolic process] GO:0006032 [chitin catabolic process] GO:0008061 [chitin binding] Show all	145 aa 16.8 kDa	No	0
CHI3L2-010 ENSP00000435935 ENST00000472825	H0YEJ1 [Direct mapping] Chitinase-3-like protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0008061 [chitin binding] Show all	42 aa 4.9 kDa	No	0
CHI3L2-011 ENSP00000436006 ENST00000497587	E9PRL9 [Direct mapping] Chitinase-3-like protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004553 [hydrolase activity, hydrolyzing O-glycosyl compounds] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005975 [carbohydrate metabolic process] GO:0008061 [chitin binding] Show all	122 aa 13.9 kDa	No	0
CHI3L2-012 ENSP00000432049 ENST00000524472	Q15782 [Direct mapping] Chitinase-3-like protein 2 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004553 [hydrolase activity, hydrolyzing O-glycosyl compounds] GO:0004568 [chitinase activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005975 [carbohydrate metabolic process] GO:0006032 [chitin catabolic process] GO:0008061 [chitin binding] GO:0030246 [carbohydrate binding] Show all	311 aa 34.6 kDa	No	0
CHI3L2-015 ENSP00000431968 ENST00000486561	E9PIX1 [Direct mapping] Chitinase-3-like protein 2 Show all	MEMSAT3 predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004553 [hydrolase activity, hydrolyzing O-glycosyl compounds] GO:0004568 [chitinase activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005975 [carbohydrate metabolic process] GO:0006032 [chitin catabolic process] GO:0008061 [chitin binding] Show all	201 aa 22.8 kDa	Yes	0
CHI3L2-016 ENSP00000436077 ENST00000528451	E9PR52 [Direct mapping] Chitinase-3-like protein 2 Show all	MEMSAT3 predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004553 [hydrolase activity, hydrolyzing O-glycosyl compounds] GO:0004568 [chitinase activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005975 [carbohydrate metabolic process] GO:0006032 [chitin catabolic process] GO:0008061 [chitin binding] Show all	221 aa 25.2 kDa	Yes	0
CHI3L2-017 ENSP00000433176 ENST00000533831	H0YD88 [Direct mapping] Chitinase-3-like protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004553 [hydrolase activity, hydrolyzing O-glycosyl compounds] GO:0004568 [chitinase activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005975 [carbohydrate metabolic process] GO:0006032 [chitin catabolic process] GO:0008061 [chitin binding] Show all	161 aa 18 kDa	No	0
CHI3L2-201 ENSP00000358763 ENST00000369748	Q15782 [Direct mapping] Chitinase-3-like protein 2 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004553 [hydrolase activity, hydrolyzing O-glycosyl compounds] GO:0004568 [chitinase activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005975 [carbohydrate metabolic process] GO:0006032 [chitin catabolic process] GO:0008061 [chitin binding] GO:0030246 [carbohydrate binding] Show all	390 aa 43.5 kDa	Yes	0

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The Human Protein Atlas

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