Expression of SBNO2 in cancer - Summary - The Human Protein Atlas

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SBNO2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SBNO2
Gene description	Strawberry notch homolog 2 (Drosophila)
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (HDLM-2)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA041867
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA041867

GENE INFORMATION
Gene name	SBNO2 (HGNC Symbol)
Synonyms	FLJ00173, KIAA0963, Sno, Stno
Description	Strawberry notch homolog 2 (Drosophila) (HGNC Symbol)
Entrez gene summary
Chromosome	19
Cytoband	p13.3
Chromosome location (bp)	1107636 - 1174283
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000064932 (version 83.38)
Entrez gene	22904
UniProt	Q9Y2G9 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9Y2G9
Antibodypedia	SBNO2 antibodies

PROTEIN BROWSER

SBNO2-001	SBNO2-002	SBNO2-003	SBNO2-010	SBNO2-011	SBNO2-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SBNO2-001 ENSP00000354733 ENST00000361757	Q9Y2G9 [Direct mapping] Protein strawberry notch homolog 2 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0002281 [macrophage activation involved in immune response] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0006351 [transcription, DNA-templated] GO:0030282 [bone mineralization] GO:0030316 [osteoclast differentiation] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0050727 [regulation of inflammatory response] GO:0061430 [bone trabecula morphogenesis] GO:0071222 [cellular response to lipopolysaccharide] GO:0071348 [cellular response to interleukin-11] GO:0071354 [cellular response to interleukin-6] GO:0072674 [multinuclear osteoclast differentiation] GO:0072675 [osteoclast fusion] GO:1990830 [cellular response to leukemia inhibitory factor] Show all	1366 aa 150.3 kDa	No	0
SBNO2-002 ENSP00000468520 ENST00000587024	K7ES28 [Direct mapping] Protein strawberry notch homolog 2 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006355 [regulation of transcription, DNA-templated] GO:0050727 [regulation of inflammatory response] Show all	1356 aa 149.1 kDa	No	0
SBNO2-003 ENSP00000400762 ENST00000438103	Q9Y2G9 [Direct mapping] Protein strawberry notch homolog 2 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0002281 [macrophage activation involved in immune response] GO:0005575 [cellular_component] GO:0006351 [transcription, DNA-templated] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0050727 [regulation of inflammatory response] GO:0071222 [cellular response to lipopolysaccharide] GO:0071348 [cellular response to interleukin-11] GO:0071354 [cellular response to interleukin-6] GO:1990830 [cellular response to leukemia inhibitory factor] Show all	1309 aa 144.2 kDa	No	0
SBNO2-010 ENSP00000466861 ENST00000590176	K7ENA9 [Direct mapping] Protein strawberry notch homolog 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006355 [regulation of transcription, DNA-templated] GO:0050727 [regulation of inflammatory response] Show all	128 aa 13.8 kDa	No	0
SBNO2-011 ENSP00000468302 ENST00000587655	K7ERL2 [Direct mapping] Protein strawberry notch homolog 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006355 [regulation of transcription, DNA-templated] GO:0050727 [regulation of inflammatory response] Show all	111 aa 12 kDa	No	0
SBNO2-012 ENSP00000468534 ENST00000590998	K7ENA9 [Direct mapping] Protein strawberry notch homolog 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006355 [regulation of transcription, DNA-templated] GO:0050727 [regulation of inflammatory response] Show all	128 aa 13.8 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.