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AP3D1

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GENERAL INFORMATION

Gene name

 AP3D1

Gene description

 Adaptor-related protein complex 3, delta 1 subunit

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the cytosol.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Cytosol (approved)

Single-cell variation

 Single-cell variation in protein expression observed.

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA074408
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the cytosol.

Main location

 Cytosol (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA074408 MCF7 Cytosol
HPA074408 RT4 Cytosol Intensity
HPA074408 U-2 OS Cytosol

GENE INFORMATION

Gene name

 AP3D1 (HGNC Symbol)

Synonyms

 ADTD

Description

 Adaptor-related protein complex 3, delta 1 subunit (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a subunit of the AP3 adaptor-like complex, which is not clathrin-associated, but is associated with the golgi region, as well as more peripheral structures. The AP-3 complex facilitates the budding of vesicles from the golgi membrane, and may be directly involved in trafficking to lysosomes. This subunit is implicated in intracellular biogenesis and trafficking of pigment granules, and possibly platelet dense granules and neurotransmitter vesicles. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

Chromosome

 19

Cytoband

 p13.3

Chromosome location (bp)

 2100988 - 2164465

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000065000 (version 83.38)

Entrez gene

 8943

UniProt

 O14617 (UniProt - Evidence at protein level)

neXtProt

 NX_O14617

Antibodypedia

 AP3D1 antibodies

PROTEIN BROWSER
AP3D1-001
AP3D1-002
AP3D1-011
AP3D1-012

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AP3D1-001
ENSP00000347416
ENST00000355272
O14617 [Direct mapping]
AP-3 complex subunit delta-1
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   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0000139 [Golgi membrane]
GO:0005215 [transporter activity]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005765 [lysosomal membrane]
GO:0005794 [Golgi apparatus]
GO:0006726 [eye pigment biosynthetic process]
GO:0006886 [intracellular protein transport]
GO:0008089 [anterograde axon cargo transport]
GO:0008565 [protein transporter activity]
GO:0010008 [endosome membrane]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016192 [vesicle-mediated transport]
GO:0019882 [antigen processing and presentation]
GO:0030117 [membrane coat]
GO:0030424 [axon]
GO:0032438 [melanosome organization]
GO:0033365 [protein localization to organelle]
GO:0035646 [endosome to melanosome transport]
GO:0043195 [terminal bouton]
GO:0048007 [antigen processing and presentation, exogenous lipid antigen via MHC class Ib]
GO:0048490 [anterograde synaptic vesicle transport]
GO:0048499 [synaptic vesicle membrane organization]
GO:0051138 [positive regulation of NK T cell differentiation]
GO:0061088 [regulation of sequestering of zinc ion]
GO:0072657 [protein localization to membrane]
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 1215 aa
136.7 kDa 		No 0
AP3D1-002
ENSP00000344055
ENST00000345016
O14617 [Direct mapping]
AP-3 complex subunit delta-1
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005215 [transporter activity]
GO:0005488 [binding]
GO:0005654 [nucleoplasm]
GO:0005765 [lysosomal membrane]
GO:0005794 [Golgi apparatus]
GO:0006726 [eye pigment biosynthetic process]
GO:0006886 [intracellular protein transport]
GO:0008089 [anterograde axon cargo transport]
GO:0008565 [protein transporter activity]
GO:0010008 [endosome membrane]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016192 [vesicle-mediated transport]
GO:0030117 [membrane coat]
GO:0032438 [melanosome organization]
GO:0035646 [endosome to melanosome transport]
GO:0048490 [anterograde synaptic vesicle transport]
GO:0061088 [regulation of sequestering of zinc ion]
GO:0072657 [protein localization to membrane]
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 1153 aa
130.2 kDa 		No 0
AP3D1-011
ENSP00000468449
ENST00000586370
K7ERW8 [Direct mapping]
AP-3 complex subunit delta-1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 155 aa
17 kDa 		No 0
AP3D1-012
ENSP00000466267
ENST00000589369
K7ELX8 [Direct mapping]
AP-3 complex subunit delta-1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 193 aa
20.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.