Expression of SLC9A3R2 in cancer - Summary - The Human Protein Atlas

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SLC9A3R2

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SLC9A3R2
Gene description	Solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
Protein class	Predicted intracellular proteins Transporters
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (MCF7, PC-3)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression, most abundant in endothelium and glomeruli.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.
Reliability score	Approved based on 1 antibody. HPA001672
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable).
Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA001672

GENE INFORMATION
Gene name	SLC9A3R2 (HGNC Symbol)
Synonyms	E3KARP, NHERF-2, SIP-1, TKA-1
Description	Solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the NHERF family of PDZ scaffolding proteins. These proteins mediate many cellular processes by binding to and regulating the membrane expression and protein-protein interactions of membrane receptors and transport proteins. The encoded protein plays a role in intestinal sodium absorption by regulating the activity of the sodium/hydrogen exchanger 3, and may also regulate the cystic fibrosis transmembrane regulator (CFTR) ion channel. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
Chromosome	16
Cytoband	p13.3
Chromosome location (bp)	2025356 - 2039026
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000065054 (version 83.38)
Entrez gene	9351
UniProt	Q15599 (UniProt - Evidence at protein level)
neXtProt	NX_Q15599
Antibodypedia	SLC9A3R2 antibodies

PROTEIN BROWSER

SLC9A3R2-001	SLC9A3R2-002	SLC9A3R2-003	SLC9A3R2-005	SLC9A3R2-006	SLC9A3R2-007	SLC9A3R2-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC9A3R2-001 ENSP00000408005 ENST00000424542	Q15599 [Direct mapping] Na(+)/H(+) exchange regulatory cofactor NHE-RF2 Show all	Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0006461 [protein complex assembly] GO:0008013 [beta-catenin binding] GO:0008022 [protein C-terminus binding] GO:0012505 [endomembrane system] GO:0016247 [channel regulator activity] GO:0016324 [apical plasma membrane] GO:0019902 [phosphatase binding] GO:0030165 [PDZ domain binding] GO:0032947 [protein complex scaffold] GO:0043234 [protein complex] GO:0045838 [positive regulation of membrane potential] GO:0048839 [inner ear development] GO:0050750 [low-density lipoprotein particle receptor binding] GO:0070062 [extracellular exosome] Show all	337 aa 37.4 kDa	No	0
SLC9A3R2-002 ENSP00000402857 ENST00000432365	Q15599 [Direct mapping] Na(+)/H(+) exchange regulatory cofactor NHE-RF2 Show all	Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0006461 [protein complex assembly] GO:0008013 [beta-catenin binding] GO:0008022 [protein C-terminus binding] GO:0012505 [endomembrane system] GO:0016324 [apical plasma membrane] GO:0019902 [phosphatase binding] GO:0032947 [protein complex scaffold] GO:0070062 [extracellular exosome] Show all	326 aa 36.2 kDa	No	0
SLC9A3R2-003 ENSP00000456895 ENST00000566198	Q15599 [Direct mapping] Na(+)/H(+) exchange regulatory cofactor NHE-RF2 Show all	Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0006461 [protein complex assembly] GO:0008013 [beta-catenin binding] GO:0008022 [protein C-terminus binding] GO:0012505 [endomembrane system] GO:0016324 [apical plasma membrane] GO:0019902 [phosphatase binding] GO:0070062 [extracellular exosome] Show all	226 aa 24.7 kDa	No	0
SLC9A3R2-005 ENSP00000454361 ENST00000567504	H3BMF5 [Direct mapping] Na(+)/H(+) exchange regulatory cofactor NHE-RF2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005886 [plasma membrane] GO:0032947 [protein complex scaffold] Show all	151 aa 16.5 kDa	No	0
SLC9A3R2-006 ENSP00000455909 ENST00000563587	H3BQS0 [Direct mapping] Na(+)/H(+) exchange regulatory cofactor NHE-RF2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0032947 [protein complex scaffold] Show all	231 aa 25.5 kDa	No	0
SLC9A3R2-007 ENSP00000457755 ENST00000561844	H3BUQ9 [Direct mapping] Na(+)/H(+) exchange regulatory cofactor NHE-RF2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0032947 [protein complex scaffold] Show all	166 aa 17.8 kDa	No	0
SLC9A3R2-009 ENSP00000454690 ENST00000565855	H3BN50 [Direct mapping] Na(+)/H(+) exchange regulatory cofactor NHE-RF2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0032947 [protein complex scaffold] Show all	223 aa 24.3 kDa	No	0

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