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PKN2

GENERAL INFORMATION

Gene name

 PKN2

Gene description

 Protein kinase N2

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA034861
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PROGNOSTIC SUMMARY
Prognostic marker in colorectal cancer (favourable).
Colorectal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA034861

GENE INFORMATION

Gene name

 PKN2 (HGNC Symbol)

Synonyms

 Pak-2, PRK2, PRKCL2, STK7

Description

 Protein kinase N2 (HGNC Symbol)

Entrez gene summary

Chromosome

 1

Cytoband

 p22.2

Chromosome location (bp)

 88684222 - 88836255

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000065243 (version 83.38)

Entrez gene

 5586

UniProt

 Q16513 (UniProt - Evidence at protein level)

neXtProt

 NX_Q16513

Antibodypedia

 PKN2 antibodies

PROTEIN BROWSER
PKN2-001
PKN2-002
PKN2-003
PKN2-004
PKN2-201
PKN2-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PKN2-001
ENSP00000359552
ENST00000370521
Q16513 [Direct mapping]
Serine/threonine-protein kinase N2
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004697 [protein kinase C activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007049 [cell cycle]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0010631 [epithelial cell migration]
GO:0016301 [kinase activity]
GO:0030027 [lamellipodium]
GO:0030054 [cell junction]
GO:0030496 [midbody]
GO:0032154 [cleavage furrow]
GO:0032467 [positive regulation of cytokinesis]
GO:0042826 [histone deacetylase binding]
GO:0043296 [apical junction complex]
GO:0043297 [apical junction assembly]
GO:0044822 [poly(A) RNA binding]
GO:0045070 [positive regulation of viral genome replication]
GO:0045111 [intermediate filament cytoskeleton]
GO:0045931 [positive regulation of mitotic cell cycle]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051301 [cell division]
GO:0070063 [RNA polymerase binding]
GO:2000145 [regulation of cell motility]
Show all
 984 aa
112 kDa 		No 0
PKN2-002
ENSP00000317851
ENST00000316005
B1AL79 [Direct mapping]
Protein kinase N2, isoform CRA_b; Serine/threonine-protein kinase N2
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005813 [centrosome]
GO:0007165 [signal transduction]
GO:0016021 [integral component of membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0045111 [intermediate filament cytoskeleton]
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 604 aa
68.3 kDa 		No 1
PKN2-003
ENSP00000401125
ENST00000436111
H0Y5V5 [Direct mapping]
Serine/threonine-protein kinase N2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0007165 [signal transduction]
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 211 aa
24.3 kDa 		No 0
PKN2-004
ENSP00000389076
ENST00000449189
H0Y429 [Direct mapping]
Serine/threonine-protein kinase N2
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   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
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 65 aa
7 kDa 		No 0
PKN2-201
ENSP00000359536
ENST00000370505
A0A0A0MRN8 [Direct mapping]
Serine/threonine-protein kinase N2
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0007165 [signal transduction]
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 320 aa
36.3 kDa 		No 0
PKN2-202
ENSP00000359544
ENST00000370513
Q16513 [Direct mapping]
Serine/threonine-protein kinase N2
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004697 [protein kinase C activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007049 [cell cycle]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0010631 [epithelial cell migration]
GO:0016301 [kinase activity]
GO:0030027 [lamellipodium]
GO:0030054 [cell junction]
GO:0030496 [midbody]
GO:0032154 [cleavage furrow]
GO:0032467 [positive regulation of cytokinesis]
GO:0042826 [histone deacetylase binding]
GO:0043296 [apical junction complex]
GO:0043297 [apical junction assembly]
GO:0044822 [poly(A) RNA binding]
GO:0045070 [positive regulation of viral genome replication]
GO:0045111 [intermediate filament cytoskeleton]
GO:0045931 [positive regulation of mitotic cell cycle]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051301 [cell division]
GO:0070063 [RNA polymerase binding]
GO:2000145 [regulation of cell motility]
Show all
 936 aa
106.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.