Expression of WDR18 in cancer - Summary - The Human Protein Atlas

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WDR18

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	WDR18
Gene description	WD repeat domain 18
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear and cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA050193 , HPA050200
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA050193	HPA050200

GENE INFORMATION
Gene name	WDR18 (HGNC Symbol)
Synonyms	Ipi3
Description	WD repeat domain 18 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	p13.3
Chromosome location (bp)	984271 - 998438
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000065268 (version 83.38)
Entrez gene	57418
UniProt	Q9BV38 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BV38
Antibodypedia	WDR18 antibodies

PROTEIN BROWSER

WDR18-001	WDR18-003	WDR18-004	WDR18-008	WDR18-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
WDR18-001 ENSP00000476117 ENST00000585809	Q9BV38 [Direct mapping] WD repeat-containing protein 18 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0007275 [multicellular organismal development] Show all	432 aa 47.4 kDa	No	0
WDR18-003 ENSP00000484670 ENST00000591997	A0A087X237 [Direct mapping] WD repeat-containing protein 18 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	144 aa 15.7 kDa	No	0
WDR18-004 ENSP00000464855 ENST00000587001	K7EIR0 [Direct mapping] WD repeat-containing protein 18 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	409 aa 44.8 kDa	No	0
WDR18-008 ENSP00000475744 ENST00000607440	U3KQC1 [Direct mapping] WD repeat-containing protein 18 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	394 aa 43.2 kDa	No	0
WDR18-011 ENSP00000251289 ENST00000251289	A0A0A0MQU0 [Direct mapping] WD repeat-containing protein 18 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	429 aa 46.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.