Expression of GLP2R in cancer - Summary - The Human Protein Atlas

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GLP2R

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	GLP2R
Gene description	Glucagon-like peptide 2 receptor
Protein class	FDA approved drug targets G-protein coupled receptors Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (pancreatic cancer)
HPA (cell line):	Cell line enhanced (A549, HeLa, SiHa)
HPA (normal tissue):	Tissue enhanced (gallbladder)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective expression in enteroendocrine cells in the intestinal tract.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA049244
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (pancreatic cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

Pancreatic cancer

STAINING SUMMARY

HPA049244

GENE INFORMATION
Gene name	GLP2R
Synonyms
Description	Glucagon-like peptide 2 receptor (HGNC Symbol)
Entrez gene summary	This gene encodes a G protein-coupled receptor that is closely related to the glucagon receptor and binds to glucagon-like peptide-2 (GLP2). Signalling through GLP2 stimulates intestinal growth and increases villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. [provided by RefSeq, Dec 2014]
Chromosome	17
Cytoband	p13.1
Chromosome location (bp)	9822206 - 9892102
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000065325 (version 83.38)
Entrez gene	9340
UniProt	O95838 (UniProt - Evidence at transcript level)
neXtProt	NX_O95838
Antibodypedia	GLP2R antibodies

PROTEIN BROWSER

GLP2R-001	GLP2R-003	GLP2R-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GLP2R-001 ENSP00000262441 ENST00000262441	O95838 [Direct mapping] Glucagon-like peptide 2 receptor Show all	G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM FDA approved drug targets Biotech drugs Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0004967 [glucagon receptor activity] GO:0005886 [plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway] GO:0008284 [positive regulation of cell proliferation] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0071377 [cellular response to glucagon stimulus] Show all	553 aa 63 kDa	No	7
GLP2R-003 ENSP00000458242 ENST00000574745	I3L0P5 [Direct mapping] Glucagon-like peptide 2 receptor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	373 aa 43 kDa	No	7
GLP2R-005 ENSP00000303605 ENST00000304773	E9PC86 [Direct mapping] Glucagon-like peptide 2 receptor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	118 aa 13.9 kDa	No	3

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.